In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Ida Sim, MD, PhD, a primary care physician and UCSF’s Chief Research Informatics Officer, discuss generative AI, large language models, and the ways in which AI could affect humanity in medicine. Related Content:

• The Promise and Pitfalls of AI in the Complex World of Diagnosis, Treatment, and Disease Management