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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the effects of mifepristone on glycemic control in adults with inadequately controlled type 2 diabetes and hypercortisolism. Here we go!

1. Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment (0:00 – 10:24).

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a Classic Rapid Fire episode. This week, Drs. Mike and John Fralick discuss two recent papers: the effects of infrequent zoledronate administration on vertebral fracture prevention in early postmenopausal women, and the efficacy and safety of semaglutide in adults with type 1 diabetes and obesity. Two papers, here we go!

1. Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age (0:00 – 10:24)
2. Semaglutide in Adults with Type 1 Diabetes and Obesity (10:25 – 17:48)

And for the Good Stuff (17:49 – 19:46):

• Canadian tennis player Victoria Mboko wins the Canadian Open!
• The I'm Pharmacy podcast— coming soon to www.medicinepods.com.

Thank you to our sponsor, FIGS scrubs. Rounds Table listeners can save 20% on their next purchase with code FIGSCA at https://www.wearfigs.com/.

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a Classic Rapid Fire episode. This week, Drs. Mike and John Fralick discuss two recent papers: the effects of perioperative hypotension-avoidance versus hypertension-avoidance
strategies on delirium and 1-year cognitive decline after noncardiac surgery, and the effect of as-needed albuterol–budesonide on risk of severe asthma exacerbation among patients with moderate-to-severe asthma. Two papers, here we go!

1. Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery (0:00 – 11:25)
2. As-Needed Albuterol–Budesonide in Mild Asthma (11:26 – 21:12)

And for the Good Stuff (21:13 – 23:17):

• Shout out to all the emergency medicine physicians!
• If you are interested in checking out the alpha version of the chatbot for One-Pagers for the Wards, reach out to Mike at [email protected].

Thank you to our sponsor, FIGS scrubs. Rounds Table listeners can save 20% on their next purchase with code FIGSCA at https://www.wearfigs.com/.

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial examining the effect of bedtime vs morning administration of antihypertensive medications on major cardiovascular events and death. Here we go!

1. Antihypertensive Medication Timing and Cardiovascular Events and Death: The BedMed Randomized Clinical Trial (0:00 – 5:18).

The Good Stuff:

• Resources for trainees (5:19 - 6:20):
  • Medicine Pods: https://medicinepods.com/
  • Life in the Fast Lane: https://litfl.com/ecg-library/

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! In this throwback episode, Drs. Mike and John Fralick chat about five important research studies published in 2024:

1. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (FINEARTS-HF) (0:00 – 4:09)
2. Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA) (4:10 – 9:28)
3. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (FLOW) (9:29 – 14:23)
4. Tirzepatide for Metabolic-Dysfunction Associated Steatohepatitis with Liver Fibrosis (SYNERGY-NASH) (14:24 – 20:28)
5. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections (BALANCE) (20:29 – 23:59)

And for the Good Stuff:

• Toronto Star Santa Claus Fund, Calgary Food Bank, Epilepsy Canada (24:00 - 25:23)

Calling keen trainees!

• Trainees, med students, residents: The Rounds Table and Trial Files (https://trialfiles.substack.com/) are looking for keen individuals to support our efforts.
• Reach out to [email protected] if you are interested in getting involved. 

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the simultaneous initiation of SGLT2 inhibitors and finerenone (a nonsteroidal mineralocorticoid receptor antagonist) in persons with chronic kidney disease and type 2 diabetes. Here we go!

1. Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes (0:00 – 9:28).

Calling keen trainees! (9:29 - 10:28)

• Trainees, med students, residents: The Rounds Table and Trial Files are looking for keen individuals to support our efforts.
• Trial Files is a free monthly newsletter on practice-changing trials, delivered straight to your inbox (https://trialfiles.substack.com/).
• Reach out to [email protected] if you are interested in getting involved. 

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back this week with a special podcast episode. Dr. Mike Fralick sits down with Dr. Karim Ladak—rheumatologist and internist, Clinical Assistant Professor at McMaster University, and host of the Rheumatology for the Royal College podcast—to talk about leukocytoclastic vasculitis. Here we go!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial exploring the effects of add-on sotatercept in patients with advanced pulmonary arterial hypertension and a high risk of death. Here we go!

1. Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death (0:00 – 5:38).

The Good Stuff:

• 2025 Scripps National Spelling Bee winning word: éclaircissement (5:39 - 6:34)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a special Rapid Fire Podcast. This week, Dr. Mike Fralick and guest host Danielle Cutler discuss the top papers from the 2025 American Diabetes Association (ADA) Scientific Session. Hot off the presses, here we go!

1. Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial (0:00 - 6:05)
2. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (6:06 - 13:22)
3. Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes (13:23 - 20:35)

The Good Stuff:

• Diabetes Trial Files - Free monthly newsletter! Subscribe at https://diabetestrialfiles.substack.com/ (20:36 - 21:00)
• Congrats to Danielle and all the med students finishing their academic year! (21:01 - 21:57)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have the next episode in our Clinical Practice Guidelines series. Drs. Mike and John Fralick discuss the top takeaways from the 2024 KDIGO Clinical Practice Guidelines for chronic kidney disease. Here we go!

1. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (0:00 - 24:24)

Access the KDIGO 2024 "Top 10 Takeaways" PDFs here: https://kdigo.org/guidelines/ckd-evaluation-and-management/

The Good Stuff:

• Nephrology Trial Files - https://nephrotrialfiles.substack.com/ (24:25 - 24:48)
• The Phoenician Scheme (24:49 - 25:33)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods