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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial examining the effect of caffeinated coffee consumption compared with abstinence from coffee and caffeine on recurrent atrial fibrillation (AF). Here we go!

1. Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation:
   The DECAF Randomized Clinical Trial (0:00 – 4:32).

The Good Stuff (4:33 – 5:29):

• Moss in space! (https://www.cbc.ca/news/science/space-moss-9.6984791)

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Happy New Year, Rounds Table Listeners! In this throwback episode (initial release 29 May 2025), Dr. Mike Fralick and special guest Dr. David Juurlink, pharmacologist and internist, Professor of Medicine at the University of Toronto, and head of the Clinical Pharmacology and Toxicology division at Sunnybrook Health Sciences Centre, sit down to chat about the top drug interactions you might be missing. Here we go!

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Welcome back Rounds Table Listeners! In our year-end episode, Drs. Mike and John Fralick discuss five important research studies published in 2025:

1. Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO) (0:00 – 4:20)
2. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity (SUMMIT) (4:21 – 9:30)
3. Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC) (9:31 – 15:03)
4. Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial (FRESH-UP) (15:04 – 18:09)
5. Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (ESSENCE) (18:10 – 23:49)

The Good Stuff (23:50 – 25:27):

• Toronto Star Santa Claus Fund, Calgary Food Bank, The War Amps 

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! In this solo episode, Dr. Mike Fralick discusses a recent meta-analysis examining beta-blockers after myocardial infarction in patients with an ejection fraction of at least 50% and no other indications for beta-blocker therapy. Here we go!

1. Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction (0:00 – 8:54).

The Good Stuff (8:55 – 9:43):

• NPR Music Tiny Desk Concerts

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! In this solo episode, Dr. Mike Fralick discusses a recent trial examining whether noninvasive blood-pressure monitoring is noninferior to early insertion of an arterial catheter in patients with shock admitted to the ICU. Here we go!

1.  Deferring Arterial Catheterization in Critically Ill Patients with Shock (0:00 – 11:05).

The Good Stuff (11:06 – 11:59):

• We've launched Critical Care Trial Files! https://criticalcaretrialfiles.substack.com/

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial comparing rituximab with conventional strategy for the induction of remission in patients with eosinophilic granulomatosis with polyangiitis (EGPA). Here we go!

1. Rituximab Versus Conventional Therapy for Remission Induction in Eosinophilic Granulomatosis With Polyangiitis: A Randomized Controlled Trial (0:00 – 5:40).

The Good Stuff (5:41 – 6:31):

• The I'm Pharmacy podcast, now featured on Medicine Pods: https://medicinepods.com/im-pharmacy/.

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! This week, Dr. Mike Fralick welcomes returning guest Dr. Yatin Chadha, radiologist at North York General Hospital and founder of the beyond MD podcast, to chat about Dr. Chadha's recently launched online course series beyond Radiology. Here we go!

Check out Dr. Chadha's course series beyond Radiology:

• CT Head Basics for Clinicians - Ruling out Neurosurgical Emergencies
• CT Head Basics - Artifact or Pathology?

Learn more about Dr. Chadha and his work:

• https://www.beyondmd.ca/
• https://www.linkedin.com/in/yatin-chadha/

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recent systematic review and meta-analysis that looks at continuing versus withholding RAS inhibitors before noncardiac surgery. Here we go!

1. Evaluating the risks and benefits of continuing versus withholding renin–angiotensin system inhibitors: a systematic review and meta-analysis with trial sequential analysis (0:00 – 8:20).

The Good Stuff (8:21 – 9:44):

• NotebookLM

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a Classic Rapid Fire episode. This week, Drs. Mike and John Fralick discuss two recent papers: the effects of spironolactone on heart failure and cardiovascular death in patients undergoing maintenance dialysis, and antibiotic prophylaxis in patients with cirrhosis and upper gastrointestinal bleeding. Two papers, here we go!

1. Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial (0:00 – 7:19)
2. Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis: A Systematic Review and Bayesian Meta-Analysis (7:20 – 15:08)

And for the Good Stuff (15:09 – 17:51):

• The $500m slugger who helped Canada get to the World Series
• Clinical practice guidelines one-pagers coming soon to Trial Files: https://trialfiles.substack.com/

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! In this throwback episode (initial release 14 Mar 2024), Dr. Mike Fralick and special guest, Dr. Laiya Carayannopoulos from the Intern at Work Podcast, discuss two papers: one exploring the role of non-invasive ventilation in comatose patients after acute poisoning, and and one on the use of the PEN-FAST Score in the point-of-care risk assessment of penicillin allergy. Two papers, here we go!

1. Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning (0:00 – 16:25).
2. Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy (16:26 – 24:17).

And for the Good Stuff:

• Celebrating Research Success! (24:18 – 25:14).
• Non-inferiority results: everything you need know in 5 minutes! and Is Noninferior Not Inferior? (25:15 – 26:48).

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods