In this episode Sean O’Leary, MD, MPH, FAAP, vice chair of the AAP Committee on Infectious Diseases, describes the characteristics of SARS-CoV-2 and what it might take to end the pandemic. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also talk to Jeffrey S. Gerber, MD, PhD, FAAP, chair of the Antimicrobial Resistance and Stewardship Subcommittee of COID, about his efforts to end unnecessary prescribing of antibiotics in pediatrics.