Dr. Ted Lain and Dr. Patti Farris cut through the hype around today's most popular longevity supplements.

They dig into the real (and often surprisingly thin) clinical evidence behind NAD precursors like NMN and nicotinamide riboside, the gut-derived compound Urolithin A, creatine for brain and muscle health, multivitamins and the buzzy Cosmos trial, and off-label rapamycin use.

Along the way, they talk through epigenetic clocks, precision medicine, why mouse studies don't always translate to humans, and why "TBD" might be the most honest verdict on longevity science right now.

Plus, details on their upcoming Science of Skin Longevity Summit, February 19–21, 2027, in Scottsdale, Arizona.

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

Board-certified dermatologists Dr. Ted Lain and pediatric dermatology expert Dr. Lisa Swanson break down the latest pediatric dermatology treatments in this episode of the Science of Skin Podcast.

Topics covered: atopic dermatitis (eczema) treatment updates including Zoryve, Vtama, and Opzelura; pediatric psoriasis therapies including Zoryve foam, Tremfya, and the oral IL-23 inhibitor Sotyktu; GLP-1 medications (Ozempic/semaglutide) for psoriasis and hidradenitis suppurativa; spironolactone dosing for teenage female acne; hemangioma treatment with timolol, propranolol (Hemangiol), and nadolol; molluscum contagiosum treatment with Ycanth and berdazimer gel (Zelsuvmi); and JAK inhibitors (Litfulo, Olumiant, Rinvoq) for pediatric alopecia areata and early intervention strategies.

Plus: a lighthearted dive into Bachelor Nation, Secret Lives of Mormon Wives, Love Island, and Taylor Swift's wedding buzz.

Send episode topic ideas to [email protected]. Subscribe and leave a 5-star rating to support the show.

Join us at the Science of Skin Summit, September 17–20 in Austin, Texas, and the Longevity Conference, February 19–21 in Scottsdale, Arizona. Learn more at scienceofskinsummit.com.

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

Board-certified dermatologists Dr. Ted Lain and pediatric dermatology expert Dr. Lisa Swanson break down the latest pediatric dermatology treatments in this episode of the Science of Skin Podcast.

Topics covered: atopic dermatitis (eczema) treatment updates including Zoryve, Vtama, and Opzelura; pediatric psoriasis therapies including Zoryve foam, Tremfya, and the oral IL-23 inhibitor Sotyktu; GLP-1 medications (Ozempic/semaglutide) for psoriasis and hidradenitis suppurativa; spironolactone dosing for teenage female acne; hemangioma treatment with timolol, propranolol (Hemangiol), and nadolol; molluscum contagiosum treatment with Ycanth and berdazimer gel (Zelsuvmi); and JAK inhibitors (Litfulo, Olumiant, Rinvoq) for pediatric alopecia areata and early intervention strategies.

Plus: a lighthearted dive into Bachelor Nation, Secret Lives of Mormon Wives, Love Island, and Taylor Swift's wedding buzz.

Send episode topic ideas to [email protected]. Subscribe and leave a 5-star rating to support the show.

Join us at the Science of Skin Summit, September 17–20 in Austin, Texas, and the Longevity Conference, February 19–21 in Scottsdale, Arizona. Learn more at scienceofskinsummit.com.

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

See omnystudio.com/listener for privacy information.

Up to 70% of people say they have sensitive skin — but is it really a diagnosis, or something else entirely? Dr. Patti Farris and Dr. Ted Lain break down the biology dermatologists are still trying to figure out.

In this episode of the Science of Skin Podcast, Patti and Ted dig into a 15,000+ person global study on sensitive skin prevalence, and explore the science behind why skin reacts with no visible cause — covering TRPV1 and TRPA1 receptor activity, neuropeptide release (substance P, CGRP), and the connection to rosacea. They also unpack the exposome: how pollution, UV exposure, hormones, menopause, and the skin microbiome all play a role, including a deep dive into aryl hydrocarbon receptor (AHR) activation and inflammation. The episode closes with a new comparative cleanser study using D-Squame tape stripping and colorimetric index of mildness (SIM) testing, showing how Cetaphil Gentle Skin Cleanser performs against other "gentle" cleansers on the market.

🔔 Subscribe for new episodes of the Science of Skin Podcast, bringing you cutting-edge dermatology and skincare science.

RESOURCES & LINKS
📧 Questions or episode ideas? Email: [email protected]
🎟️ Join us in Austin, TX — Science of Skin Summit, Sept 17–20, 2026
🎟️ Science of Skin Longevity Summit — Scottsdale, AZ, Feb 2027
🌐 Learn more: scienceofskinsummit.com

Case Study Link: A Comparative Analysis of 8 Facial Cleansers Using Corneosurfametry Reveals Differentiated Irritation Potential - JDDonline - Journal of Drugs in Dermatology

This episode is sponsored by Galderma.

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

See omnystudio.com/listener for privacy information.

🎧 In this episode of the Science of Skin Podcast, host Dr. Patty Farris sits down with Dr. Rishi Chopra — a Harvard-trained, fellowship-trained cosmetic dermatologist from the Mass General Wellman Center for Photomedicine — for a deep dive into the evolution of fractionated laser resurfacing.

Dr. Chopra breaks down how fractional photothermolysis, first described by Drs. Rox Anderson and Dieter Manstein in 2004, transformed dermatology by moving away from painful, high-downtime ablative resurfacing toward safer, more effective treatments. He walks through the progression from the original Fraxel Restore to the Fraxel Dual and the newly launched Fraxel FTX, explaining the science behind each wavelength (1550nm, 1927nm) and how these advances made treatments more tolerable, more precise, and safer for patients with skin of color.

The conversation also covers a remarkable patient case: a young man with severe acne scarring who saw nearly 100% improvement after six Fraxel FTX treatments — illustrating just how far this technology has come. Dr. Chopra then discusses the Clear + Brilliant Touch, a lower-downtime "lunchtime facial" option that's especially popular with younger patients and serves as both an entry point and a maintenance tool for building long-term patient trust.

Whether you're a dermatology professional refining your device menu or simply curious about the science behind modern laser resurfacing, this episode offers a comprehensive, practical look at how far fractionated laser technology has come — and where it's headed next.

In this episode:

• The history of ablative vs. fractionated laser resurfacing
• Fraxel Restore → Dual → FTX: what changed and why
• Treating acne scars and photoaging safely in skin of color
• A dramatic real-world patient case study
• Clear + Brilliant Touch as a "lunchtime facial" option
• Building patient trust through a tiered treatment approach

This episode is sponsored by Solta Medical. Dr. Chopra has been compensated by Solta Medical for his participation.

Full prescribing and safety information for Fraxel and Clear + Brilliant laser systems is available at www.fraxel.com/HCP and www.clearandbrilliant.com/HCP.

See omnystudio.com/listener for privacy information.

Dr. Ted Lain sits down with board-certified pediatric dermatologist Dr. Nnenna Agim to discuss the toddler indication for roflumilast cream (Zoryve) and how non-steroidal topicals are changing the treatment landscape for atopic dermatitis, psoriasis, and seborrheic dermatitis in children.

In this episode of the Science of Skin Podcast, Dr. Agim shares her real-world clinical experience using roflumilast cream 0.05% (ages 2-5) and 0.15% (ages 6+) as a steroid-sparing alternative for pediatric eczema, explaining why more families are requesting non-steroidal options from the start of treatment. The conversation covers:

• Why roflumilast (Zoryve) is safe to use on any body surface, including the face and skin folds
• Managing parent expectations and proper dosing to avoid overuse
• The importance of pairing roflumilast with ceramide-rich, fragrance-free moisturizers like CeraVe, La Roche-Posay, and Vaseline
• How roflumilast compares to crisaborole (Eucrisa) and topical corticosteroids in tolerability
• Treating psoriasis and seborrheic dermatitis in children with roflumilast foam and cream
• Skin barrier repair, ceramide production, and the role of the acid mantle in atopic dermatitis
• Caring for textured hair and scalp conditions in pediatric patients
• Real patient outcomes and quality-of-life improvements with Zoryve

This episode is sponsored by Arcutis Biotherapeutics and is part of an ongoing series exploring roflumilast formulation science. Don't miss the related episode on roflumilast's formulation with Dr. Chris Bunick.

Learn more about the Science of Skin Summit (Austin, TX) and the new Science of Skin Longevity Summit (Scottsdale, AZ, Feb 2027) at scienceofskinsummit.com.

🔔 Subscribe and leave a 5-star rating to support the show!

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

See omnystudio.com/listener for privacy information.

In this episode of the Science of Skin podcast, board-certified dermatologist Dr. Patti Farris sits down with Golden Follicle Award winner and hair restoration surgery pioneer Dr. Nicole Rogers to break down everything you need to know about hair loss treatment — from trending social media remedies to cutting-edge clinical trials.

Whether you're experiencing male pattern baldness, female pattern hair loss, postpartum shedding, or hair thinning from GLP-1 weight loss drugs, this episode covers it all. Dr. Rogers shares her expert framework for building a personalized hair loss treatment plan and explains exactly when to move from over-the-counter solutions to prescription therapies.

Topics covered include:

• Rosemary oil, pumpkin seed oil & nutraceuticals — do they actually work?
• Oral minoxidil vs. topical minoxidil — what the latest research shows
• Extended-release oral minoxidil (Veridermix) — the next FDA-approved hair loss drug?
• Finasteride and dutasteride for men and women — dosing, safety, and the truth about post-finasteride syndrome
• Spironolactone for pre-menopausal women with hair loss
• Topical finasteride and dutasteride via compounding pharmacy
• Low-level laser/red light therapy (LLLT) for hair growth — what the science really says
• PRP (platelet-rich plasma) injections — when they help and when they're overhyped
• Exosomes for hair loss — promise vs. FDA concerns
• PP405 and stem cell activation — the groundbreaking new molecule in clinical trials
• FUE vs. FUT hair transplant surgery — what's right for you
• No-shave FUE — the emerging frontier in hair restoration
• Hair transplants for women — why strip harvesting remains the gold standard

If you're searching for answers on androgenetic alopecia, alopecia areata, telogen effluvium, scalp health, DHT blockers, hair regrowth treatments, or the best dermatologist-recommended solutions for thinning hair, this is the episode you've been waiting for. Dr. Rogers brings decades of clinical expertise, peer-reviewed research, and real patient outcomes to help you navigate the overwhelming world of hair loss — with science, not social media hype.

🎙️ Subscribe, leave a review, and share with anyone on their hair loss journey. New episodes available on Apple Podcasts and Spotify.

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

See omnystudio.com/listener for privacy information.

Are you a dermatologist curious about clinical research — or a seasoned trialist looking to reignite your passion? In this episode of the Science of Skin Podcast, Dr. Ted Lane (Austin, TX) sits down with Dr. Jason Hawkes, Chief Scientific Officer at Oregon Medical Research Center, to pull back the curtain on what it really means to build a career in dermatology clinical trials.

From navigating the growing complexity of modern trial protocols to reframing the pharma-physician relationship, Ted and Jason share candid insights that only experienced clinical trialists can offer. They discuss how running trials makes you a sharper diagnostician, why medical dermatology remains one of the most rewarding specialties, and how industry partnerships open unexpected academic and commercial doors.

You'll also hear their honest takes on mentorship — including the must-read JAMA article Mentorship Malpractice — and why thinking of your career as a lattice, not a ladder may be the most liberating shift you can make.

Whether you're five years into practice or just starting out, this episode is packed with hard-won wisdom on building a meaningful, intellectually stimulating career in dermatology.

📩 Questions or future episode ideas? Email: [email protected]

Topics Covered:

• How clinical trials combat physician burnout
• The real motivations behind patient participation in trials
• How to interpret clinical data like a trialist
• Navigating the evolving complexity of trial conduct
• Building industry relationships the right way
• The importance of mentorship in dermatology research
• Career advice: "lattice, not a ladder"

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

See omnystudio.com/listener for privacy information.

What really separates roflumilast (Zoryve) from other PDE4 inhibitors — and why does it matter for your patients with atopic dermatitis, psoriasis, or seborrheic dermatitis? In this episode, Dr. Ted Lane sits down with Dr. Chris Bunick, Associate Professor of Dermatology at Yale School of Medicine and Editor-in-Chief of Dermatology Times, for a deep dive into the biochemistry, formulation science, and clinical implications behind this breakthrough topical treatment.

In this episode, you'll learn:

• Why roflumilast binds PDE4 with 200x more potency than apremilast — and 1,000x more than crisaborole
• How cyclic AMP inhibition controls upstream cytokine pathways (TH1, TH2, TH17) across multiple inflammatory skin diseases
• The science behind the Crotofos emulsifier — and why the right emulsifier protects the skin barrier instead of stripping ceramides
• Why formulating at pH 5.5 matters for filaggrin, keratin, and barrier integrity
• How the roflumilast foam is specifically engineered for scalp conditions and hair-bearing areas
• What's next in topical formulation innovation — from targeted dermal delivery to longevity skincare

Whether you're a dermatologist, resident, PA, NP, or skincare enthusiast who wants to understand the why behind cutting-edge topicals, this episode is packed with clinical and scientific insight you won't find anywhere else.

🎙️ This episode is sponsored by Arcutis Biotherapeutics, maker of roflumilast cream and foam.

📧 Send your questions to: [email protected]

📅 Science of Skin Summit — September 19–21, Austin, TX

📅 Longevity Meeting — February 19 - 21, Scottsdale, AZ

Subscribe, leave a 5-star review, and follow Dr. Bunick's podcast: ABCDs in Dermatology.

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

See omnystudio.com/listener for privacy information.

Big news for nurse practitioners and physician assistants in dermatology! Dr. Patti Farris is joined by PA and dermatology leader Kristin Rygg to announce a brand-new NP/PA track at the 2026 Science of Skin Summit — a first-of-its-kind opportunity for advanced practice providers to learn alongside their physician colleagues.

In this episode, you'll hear:

• Why this NP/PA-dedicated track was created and what makes it different
• A full breakdown of the September 10th agenda — from immunology and inflammatory skin disease to biologics, GLP-1s, and advanced skincare ingredients
• How the curriculum is designed for every career stage, from new grads to seasoned practitioners
• What to expect at the full Summit (September 17–20, 2026), including case-based learning, product theaters, and a longevity track
• How NPs and PAs will be featured on the main stage for the first time

Whether you're a PA, NP, dermatologist, or practice owner, this episode is your inside look at a summit built for collaboration, clinical excellence, and professional growth.

🔗 Register now at scienceofskinsummit.com

🔔 Subscribe to Science of Skin and leave a review — it helps us bring more cutting-edge dermatology science straight to you.

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

See omnystudio.com/listener for privacy information.