It's that time of year again, everyone rolling up their sleeves to get a flu shot. This episode dives into the history of the struggles pinning down the causative agent of flu and the journey to the vaccine!

· Intro 0:12

· In this episode 0:17

· The history of the flu: 1892 3:10

· Rabies and dead virus 10:52

· A Sickness in the Serum, Part 2 14:31

· Vaccines and trials 19:13

· Pig influenza 23:21

· Influenza: a filterable agent we can't see 27:10

· The trials of 1942 33:18

· PS: 1918 influenza 39:13

· Finding the 1918 influenza vaccine 39:54

· Thanks for listening 47:54

Disclosures: Brown reports no relevant financial disclosures.

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References:

Hicks DJ, et al. Clin Exp Immunol. 2012;doi:10.1111/j.1365-2249.2012.04592.x.

Rosenau MJ. Experiments Upon Volunteers to Determine the Cause and Mode of Spread of Influenza, Boston, November and December, 1918. https://quod.lib.umich.edu/f/flu/3750flu.0016.573. Published February 1921. Accessed December 6, 2023.

Rosenau MJ, et al. JAMA. 1925;doi:10.1001/jama.1925.02670070040019.

Taubenberger JK, et al. Antivir Ther. 2007;12(4 Pt B):581-91.

Tobin J. The first flu shot. https://heritage.umich.edu/stories/the-first-flu-shot/. Accessed December 6, 2023.