This Week with George Stephanopoulos

As U.S.-Russia tensions escalate in the standoff over Ukraine, ABC's Martha Raddatz goes one-on-one with Senate Foreign Relations Committee member Senator Chris Coons on the possibility of a Russian invasion and what’s next for the Democrats’ agenda. Plus, Senator Joni Ernst weighs in on the U.S. response, and the Senate GOP‘s block of voting rights legislation. And with the Omicron variant surge passing its peak in many states, Dr. Anthony Fauci joins Martha to discuss whether the U.S. is finally at a COVID turning point.

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ABC's Mireya Villareal is in Texas with the latest on the synagogue standoff, which ended with all four hostages escaping safely, and the suspect dead; ABC News Contributor and former FBI hostage negotiator Brad Garrett breaks down the SWAT team response; Surgeon General Vivek Murthy discusses the Biden administration's handling of the COVID-19 pandemic, while former White House Homeland Security Advisor Tom Bossert says the administration 'needs to acknowledge some failure' on that front; and House Majority Whip James Clyburn says 'we are not going to roll over' on voting rights.

As the Omicron variant pushes the U.S. healthcare system to the brink, Dr. Ashish Jha joins George Stephanopoulos to discuss the strategy of adjusting to the “new normal” of life with COVID and the impact on young children. Plus, as the Biden administration prepares for talks with Russia next week, George goes one-on-one with Secretary of State Antony Blinken on the U.S. strategy to confront tensions around Ukraine and the worsening unrest in Kazakhstan. And following the ceremonies marking the one year anniversary of the Jan. 6 insurrection, GOP Senator Mike Rounds and Democratic Senator Jaime Raskin talk about about that day and the push for accountability.

As the U.S. shatters COVID case records, ABC's Chief Anchor George Stephanopoulos goes one-on-one with Dr. Anthony Fauci about the new CDC guidelines for quarantine and isolation, testing availability, and the latest research into the Omicron variant. Plus, with the one year anniversary of the Capitol insurrection approaching, January 6th Committee Chairman Bennie Thompson and Representative Liz Cheney talk about what the committee has learned in its investigation and the state of the Republican Party. And in his first network interview after taking office, New York City Mayor Eric Adams sits down to discuss his strategy to combat the latest COVID surge and his first 100 day priorities for New York City.

With the Omicron variant now the dominant strain of Covid in the U.S., Jonathan Karl goes one-on-one with Dr. Anthony Fauci on Pres. Biden’s plan to combat the surge and FDA approval for two antiviral pills. Plus, Dr. Ashish Jha to discusses how to celebrate the holidays safely amid the Omicron surge and what the future of the pandemic will look like.

Covid cases skyrocketing to its highest levels in a year with the new omicron variant sweeping across the country, and hospitals being pushed to the brink again. ABC's Jonathan Karl spoke with Dr. Anthony Fauci on how Americans can protect themselves. Following explosive text messages to former White House chief of staff, Mark Meadows, during the Jan.6 attack on the Capitol, the House votes to hold him in contempt. President Biden's Build Back Better plan faces pushback from Sen. Joe Manchin, putting the agenda on hold. All that, plus the Powerhouse Roundtable.

Communities across the South and Midwest are digging out from a swarm of deadly tornadoes, more than 40 reported across six states, leaving scores dead, some areas completely flattened. President Biden approved an emergency declaration, promising the federal government will do everything possible to help with rescue and recovery, those efforts continuing around the clock. Then, as Russian troops mass at the Ukraine border, President Biden sends a warning to Vladimir Putin. All that, plus the Powerhouse Roundtable.

With scientists racing to understand how existing vaccines protect against Omicron, ABC's Martha Raddatz gets rare access to Moderna’s manufacturing facilities to see how they are preparing to combat the new variant. After the Supreme Court heard historic arguments over a restrictive Mississippi abortion law, Terry Moran and Kate Show analyze the future of abortion rights as the Court’s conservative majority considers overturning Roe v. Wade. And the Powerhouse Roundtable discuss Congress’ busy December agenda, the political divide over vaccine mandates, and concerns over Russian aggression toward Ukraine.

A new COVID strain is raising alarms around the world. The Omicron variant, first discovered in Southern Africa, has now spread across Europe to Australia and Hong Kong. Global markets plunged when the news broke. Countries are imposing new travel bans, the most restrictive in Israel, which has closed its borders to all foreigners for two weeks. Dr. Anthony Fauci talks to George about what you need to know about the new variant. Plus, the roundtable discusses the results of the Kyle Rittenhouse trial and the Ahmaud Arbery murder trial.