This Week with George Stephanopoulos

With Thanksgiving travel expected to return to pre-pandemic levels, Martha Raddatz goes one-on-one with Dr. Anthony Fauci about the latest on boosters shots, tips for safe holiday gatherings, and concern over new rising cases. Following the acquittal of Kyle Rittenhouse in the Kenosha shootings Byron Pitts, Terry Moran and Channa Lloyd join Martha to discuss the polarizing case and its future implications on self-defense and gun rights cases. With the holiday season approaching, Martha reports from Kansas City on the rising cost of goods -- plus analysis from Deirdre Bolton and Diane Swonk on the jump in inflation. With cyberattacks on the rise, Pierre Thomas reports from inside the National Security Agency and interviews Gen. Paul Nakasone about how the spy agency is responding to those increasing threats. And Jon Karl, Averi Harper, Laura Barrón-López and Jonathan Swan join the Powerhouse Roundtable to discuss what’s next for Biden’s Build Back Better agenda and the state of the economy as inflation surges.

It was a busy week in politics, as key states held elections on Tuesday, and the House passed the $1 trillion bipartisan infrastructure bill, sending it to President Biden's desk for a signature. Plus, Surgeon General Vivek Murthy defends the president's vaccine mandate, and Ginger Zee reports from the COP26 climate summit in Glasgow, Scotland.

The president lays down his bottom line for the Build Back Better plan, hoping to unify Democrats. But Biden heads overseas with no deal in hand. What will it take to seal the deal? The latest with Transportation Secretary Pete Buttigieg. Martha Raddatz reports on rising sea levels, alarming erosion eating at Hawaii's coastline. And the new book honoring ABC's friend, colleague and trailblazer Cokie Roberts.

It was an intense one on Capitol Hill and the campaign trail. Democrats worked behind closed doors to find a compromise on President Biden's Build Back Better agenda and voted overwhelmingly to hold top Trump adviser Steve Bannon in contempt for failing to testify on the January 6 insurrection. Plus, Chief Washington Correspondent and This Week Co-Anchor Jonathan Karl reports on the bellwether Virginia gubernatorial race and what the outcome there could foretell ahead of the 2022 midterm elections

Reports that at least 17 U.S. missionaries and their families have been kidnapped in Haiti. What we're learning this morning. Plus, a supply chain crisis, empty shelves and rising prices. President Biden calling on businesses to break the bottleneck. And an FDA panel recommends Johnson & Johnson boosters for a wide group, those 18 and older. Are they at greater risk? Now questions on mixing and matching vaccines. Dr. Anthony Fauci joins "This Week" co-anchor Martha Raddatz this morning.

After the Senate approved a debt ceiling increase through early December, George interviews Treasury Secretary Janet Yellen about the future of Pres. Biden’s agenda in Congress plus the September jobs report that missed expectations. Top Facebook executive Nick Clegg speaks for his first televised response amid calls for growing regulation of the tech giant. Amid the ongoing fallout from the subpoenas issued in the Jan. 6 probe, Jonathan Karl reveals new explosive reporting from his upcoming book “Betrayal: The Final Act of the Trump Show.” Plus, the Powerhouse round table.

As Pres. Biden pushes Democrats on Capitol Hill to end the stalemate on his signature infrastructure legislation, Jon Karl goes one-on-one with Senator Bernie Sanders on the state of negotiations as the party seeks unity. As the U.S. reaches the grim milestone of 700,000 lives lost to Covid, Jon Karl interviews Dr. Fauci on that new antiviral Covid pill from Merck and the continued divide over vaccine mandates. Plus, the Powerhouse Round table.

After pledging the House will vote on both the bipartisan infrastructure and the Democrats’ reconciliation packages, George goes one-on-one with Speaker Pelosi on the fate of Pres. Biden’s signature legislation. ABC Exclusive: After the CDC endorsed booster shots of the Pfizer vaccine for older and high-risk Americans, Pfizer Chairman and CEO Albert Bourla joins George to discuss the rollout plan plus vaccine authorization for children under 11. ABC Exclusive: In his first television interview, whistleblower and former top Trump DHS official Brian Murphy talks to George about DHS downplaying the threat of Russian election interference and white supremacist groups. Plus, the Powerhouse Round Table.

With an FDA advisory panel recommending Pfizer booster shots only for those over 65 or at high risk, Martha goes one-on-one with Dr. Anthony Fauci on the latest setback for the Biden administration in its booster plan push. After the Pentagon admitted a drone strike that killed 10 Afghan civilians was a mistake, Martha interviews Adm. Mike Mullen on the tragedy and Joint Chiefs Chairman Milley’s calls to China in the final months of the Trump presidency. Following a powerful day of testimony from U.S. gymnasts on the sexual abuse they suffered by team doctor Larry Nassar, Pierre Thomas and Christine Brennan join Martha to discuss the FBI’s failure in handling the case and what comes next.