In pregnancy, thrombophilias or blood clotting disorders can either be inherited or acquired. As you can imagine, blood clotting is not a preferred state in pregnancy a condition laden with micovessels which could clot easily.

Inherited thrombophilias are usually genetic in nature and increase the risk for thromboembolic disease. During pregnancy, the potential for these disorders to be problematic is enhanced because pregnancy is a hypercoagulable state. The most severe sequela is a resulting DVT (deep vein thrombosis) or a blood clot in a deep vein. DVTs can be life threatening and very serious.

Acquired thrombophilias are primarily the result of systemic autoimmune disease resulting in antibodies that predispose the body to clot. A term commonly used for acquired thrombophilias is antiphospholipid syndrome or APS and this condition can occur as a primary condition, or it can occur in the presence of systemic lupus erythematosus (SLE) or other autoimmune conditions.

Thrombophilias in pregnancy are reviewed in detail in this episode as well as how to manage and treat them throughout the pregnancy, labor and postpartum period.

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