Dr. Jerrica Kirkley is the chief medical officer and co-founder of Plume, a virtual healthcare center of excellence dedicated to the transgender community that provides gender-affirming medical care at the convenience of a smartphone. Kiki Freedman is the CEO and co-founder of Hey Jane, a virtual clinic offering telemedicine abortion care, which she founded while at Harvard Business School. In this conversation with Stanford Associate Professor Melissa Valentine, Kirkley and Freedman discuss the opportunities and challenges for entrepreneurs who want to help underserved patients while building successful digital healthcare companies.