Brian Armstrong is the co-founder and CEO of Coinbase, a leading cryptocurrency company that provides exchange, brokerage, and custody services to 100M+ verified users in over 100 countries. Founded in 2012, Coinbase went public in 2021 on the NASDAQ under the ticker COIN and as of August 2025 has a market cap of $83 billion. Brian is also the co-founder of New Limit, a longevity biotech company on a mission to significantly extend human lifespan that recently raised a $130M Series B led by Kleiner Perkins and angels including John and Patrick Collison, Elad Gil, and Joshua Kushner, among others.

We covered:

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Timestamps:

(0:00) Intro

(0:26) Becoming the everything chain

(4:20) Story behind the GENIUS Act

(5:33) Working with regulators

(10:45) The future of crypto and the government

(17:10) When to jump to the hot new thing

(23:03) Choosing what frontiers to prioritize

(29:59) Brain-computer interface tech

(34:48) Inside the mind of a contrarian

(43:52) Creating a sustainable lifestyle

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More on Brian:

https://www.coinbase.com/

https://www.newlimit.com/

https://x.com/brian_armstrong

More on Jack:

https://www.altcap.com/

https://x.com/jaltma

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https://linktr.ee/uncappedpod

Email: [email protected]