This episode digs into the pathophysiology of urticaria vasculitis from anti-C1q to the story of bradykinin.

·       Intro 0:11

·       In this episode 0:22

·       Review of episode 83 1:23

·       Listen to previous episode, The Complement System for Dunces 4:09

·       Anti-C1q antibodies 6:26

·       Lupus, anti-C1q and lupus nephritis 9:33

·       What happens when you inject anti-C1q in a mouse? 12:56

·       The allergy component: anti-C1q, urticaria and angioedema 17:36

·       Bradykinin-mediated angioedema and C1q deficiency 24:20

·       What is the kinin kallikrein system? 26:21

·       French researchers in 1909: human urine injected in dogs 27:30

·       How is this relevant to urticarial vasculitis? 31:08

·       SERPING1 gene mutation 31:23

·       Summary 32:06

·       COPD association with urticarial vasculitis 33:51

·       Coming up in episode 85 35:28

·       Thanks for listening 35:45

Disclosures: Brown reports no relevant financial disclosures.

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References:

Busse P, et al. J Allergy Clin Immunol Pract. 2022;doi:10.1016/j.jaip.2021.11.011.

Davis MDP, et al. J Allergy Clin Immunol Pract. 2018;doi:10.1016/j.jaip.2018.05.006.

Dorn JM, et al. Ann Allergy Asthma Immunol. 2023;doi:10.1016/j.anai.2023.06.014.

Marzano AV, et al. J Allergy Clin Immunol. 2022;doi:10.1016/j.jaci.2022.02.007.

Siegert CE, et al. Clin Immunol Immunopathol. 1993;doi:10.1006/clin.1993.1066.

Stojan G, et al. Lupus. 2016;doi:10.1177/0961203316645205.

Venzor J, et al. Clin Rev Allergy Immunol. 2002;doi:10.1385/CRIAI:23:2:201.

Wisnieski JJ, et al. Medicine. 1995;doi:10.1097/00005792-199501000-00003.