On September 12, 2022, President Biden signed an Executive Order (EO) on Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe, and Secure American Bioeconomy. The EO aims to sustain and broaden U.S. competitiveness and leadership in biotechnology and extend the impact of biotechnology across industrial areas including health, agriculture, energy, and beyond. What does this mean for the future of the U.S. bioeconomy? In this episode, Dr. Kevin O'Connell, Dr. Tara O'Toole, and Eugene Chiu explore key takeaways from the EO, including the importance of biomanufacturing regarding climate change, bioeconomy international collaborations on supply chains and national security, and how the overall economy will be impacted by the development of biotechnology.