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How do we reduce your reactions to chemicals and we've talked about chemicals. So so what do you do about it? So it's an interesting thing. First, the first thing you do about it is try to get rid is as many of 'em as you can, but the, but the topic is how do I reduce my reactions to it? So chemicals are largely the most profound effect is on the liver. Okay. Your liver does, it used to be 350 things. Now, I think it's up to 500 things that your, that your 500 metabolic pathways that your liver is involved in, literally. Okay. But it, but they have several major pathways. And I, I think I'm correct in saying that it's most prominent pathway is a glutathione pathway. And so you've probably heard a glutathione if you haven't, you're going to okay.

Because Glu thigh is a major, major, major player in being, getting well and staying well in auto immunity. And here's the reason why 25% of approximately 25% of, of the listed known triggers that trigger immune to IID disease or perpetually keep triggering. It are toxins, our chemicals, our BPA they're they're they're plastics, they're from AEH, they're all these things that, that we live in. We live in this soup of chemicals. So glutathione is the, the glutathione pathway is the pathway that is designed to take this chemical. So this chemical is actually an entity. It's actually a molecule. Okay. It comes into you, you breathe it in, you know, comes in through your lung or you put it on your skin and it's absorbed through your skin, but eventually it finds its way, your liver cause your that's what your liver's there for liver there for alcohol drugs toxins, those types of things to, to, you know, it's one of the major pathways in, in what your liver does, the glutathione pathway being the guy toxins, glutathione is the most powerful antioxidant known to man.

I pretty sure. Or that's still a correct statement and is made in our cells and is made in our liver. It's actually hard to get auto immunity if you don't, if you have enough glutathione in your system because it's, it, it does such a good job in also working with, along with vitamin D and dampen immune inflammation. It, it does so many things heals your leaky gut. It does a zillion things. I should just do one on glutathione. So, but, but if you don't have enough glutathione, you're going to, you're going to have chemical sensitivities now. Because that pathway is gonna be overwhelmed. The, the glutathione is gonna get used up. The glutathione comes in, it literally grabs the molecule. Okay. And then it literally like, you know, crushes it to, to a degree, but it, it, it brings it to a pathway where it, where the path where neutralizes it so that it can have a a another chemical attached to it, which makes it water soluble.

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Hair dye, hair bleach, and Hashimoto's. So I don't really, you could go on forever if you want to tease out every single chemical that is a trigger. That's a trigger for Hashimo. So Hashimoto's is like, I've said 39. Like I think I'm about the 41 or 42 now, but it's like, it's 40, 41 triggers. And I have presentations online. I've said 39 cuz that's what there was at the time. And so the chemical sensitivities are probably a, a quarter of those like, like 25%. I, I don't even test for 'em anymore. There's controversy. Should you test it by hair? Should you do it by hair analysis? If you're going to test for them doic type PCR, antibody tests, and look for the IgG, I G a type of stuff and even IgM to make sure that you're, you don't have an allergy to it, but, but I don't even test for it.

I mean that I've been doing this for a long time and I've done the testing for it and I've gone through the, oh, it's the analysis for the metals, but also for the toxins and it's urinalysis and so on and so forth and, or it's antibody testing but everything, every test I ever did, people have chemical sensitivities. I mean, I think the bottom line is more than specifically, do you have is a hair dye or bleach? Is that it's a chemical and our bodies are not designed to live in the chemical soup that we live in. That is a good example with diabetes. I know this is about Hashimotos, but there's a good example with diabetes where everybody up until like 1980 or even later said, oh, we got so much diabetes going on now because of, so we're eating so much sugar and we are, and it's a part of it, but it's interesting in the 1980s is when we really started dumping chemicals into our, into our site.

It's like, like 80,000 chemicals have been introduced since then. How many of them have been actually evaluated? Well, not many, not many at all. And the ones that have been you, you, you prior to glyphosates from the, from the spraying of the, of the foods and, and the Monsanto and that whole type of thing, which is real. Okay. So, but, but that's just one, that's just one, it's just one chemical out of, out of all of those, these chemicals go in and they are, they're shown to create inflammation.  They cause your liver to clog up. You, you end up getting itchy, maybe, maybe, or your liver to not be able to work. Right. And you start having all kinds of, of, of issues with detoxification, but in and of themselves, they have been shown to increase antibodies, to autoimmune diseases and particularly antibodies to to the thyroid proxies, enzymes of that caused the attack on your thyroid.

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Today we're gonna talk about the proinflammatory diet and Hashimoto's. So inflammatory diets are one of the many triggers of Hashimoto's tyroid disease and inflammatory foods are a lot of protein foods, it's meats and, and eggs, and, and just all, a lot of, a lot of things that are hard to digest more or less, a lot of meat, a lot of meat. And so grains, grains are there. And, and this is not the intention of me is to go through the whole ProAm diet because the, the proinflammatory diet or the pro antiinflammatory diet is it was, it was pretty much put together for auto autoimmune patients. And I think it was put together by Sarah Valentine and, and, and it's when it's still used a lot. It's still used quite a bit for, for auto immunity.

Now I I'll make a caveat. And what, and the reason that you want to follow a proinflammatory diet and the reason I'm not getting into it, I mean, you can look proinflammatory diet up online, and you'll be anti-inflammatory and you'll be, you'll be reading for a, and there's different people. Who've put 'em together, but the, the original and the classic is the anti in autoimmune paleo diet is that's the original anti-inflammatory diet. And then I've used it for years, but I don't use it as much as I used to. The premise of it is correct. The premise of it is it takes out all the foods that creates inflammation in your system, 75% of your immune system, 70%, however much it is, depending on who you're reading is in your intestines. And so it makes sense that if you have auto immunity, you start dampening inflammation in your intestines.

75% of your immune system is there. You're gonna start dampening if it immune inflammatory responses against your thyroid. Having said that there's a little caveat in here for me, about 75%, 70% of my patients come in, have something called small intestinal bacteri overgrowth. So, and that's a lot of my patients that have that. So if you go on the autoimmune paleo diet, then you will probably blow up. You'll probably start getting bloating and gas and distension. If you are one of the people who have small intestinal bacteria overgrow. So if you do that, then you need to know that you need to go to at the very, a low FODMAP diet. Another caveat is if you get on the autoimmune paleo diet and you don't seem to be doing well and you're, and, and you're not bloating up, or even if you are bloating up and if you haven't and if you don't know your food sensitivities, of course, the autoimmune paleo diet removes all of your food sensitivities, and then eventually you're supposed to start reintroducing them.

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H. pylori and Hashimotos so H. pylori is a bacteria that gets into your stomach and and when it gets into your stomach, it does bad things. without getting into the entire chemistry of it. It essentially damage the cells in your I'm sorry. I say damages. It essentially will foe. It will, it will multiply. And it'll literally cover the, the inside of your, your stomach. And sometimes it'll even go farther into other parts of your system, but, but but mainly your stomach and then it'll it, the cells in your stomach that make hydrochloric acid, the main acid that digests and sterilizes your food will cannot get to your food. It can eventually, it can, it can damage those cells. But, but for the most part, if you have a HPI infection in one of those two manners, it's gonna decrease the ability of you to digest food.

Now H. pylori is probably the most contagious infection that man has. And yet a lot of people don't know it's called Helicobacter pylori for those of you who like that type of stuff. Okay. So it's, it's the, it's the most common infection that man knows. And, and where can you get it? You can get it, you mainly get it from other family members. You can get it from your dog. Some think you can get it from your cat, but it is, it is highly transmission it's permissible. So, so essentially when you get HPI Lui it, it creates an infection. So there are several.

So there are several pathogens that can cause infections and they, and all of them you've heard of some of them are like Epstein bar virus. Some 'em are Lyme disease. Some are Py, some 'em are Botox. Some of 'em are cytomegalo viruses, Cox viruses, all of these can either trigger and or exacerbate a, a present a, a Hashimotos thyroiditis. So, and how, and so it is very simple. They're there, they exacerbate immune responses cuz the immune system is trying to kill them when the immune system flares up to try to kill them. It's it, it also can then flare up and attack the cells in your thyroid that that are, are, are gonna be damaged by the immune system. That's already been told it's okay to attack the thyroid by your, your genetics. So it's a, it's a common and it's, it is the most common trigger.

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Today we're gonna talk about dysglycemia and Hashimoto's. So dysglycemia refers to blood sugar. Disc means it's screwed up. So basically dysglycemia can be high blood sugar, low blood sugar, but it's usually somebody bouncing back and forth between high and low blood sugar. This is one of my favorite topics. So I'll do my best to try and keep it less than an hour and a half long here. This just be a couple minutes, because this is huge. This is huge, huge, huge, huge, huge. Why is it huge because everybody blows it off. What do I, what do I mean by everybody? I mean, your doctors blow it off. Low blood sugar is in the medical field, not considered a problem until it's below 60, which is almost like having no blood sugar and you're passing out and you can't stay awake.

And you're like, you know, this is like the diabetic who hasn't taken insulin or, you know, and they've run out of, and they've run outta sugar. But that's a pathological entity, low blood sugar is just you don't, you, you, you, you don't eat and you get irritable. You get shaky, you get agitated, you crave sweets, you get tired. Maybe you get trembling. All of these things are, all of these symptoms are relative to you having a blood sugar drop. When you get a blood sugar drop, it affects your it affects your brain. Obviously you get AR irritated, agitated, those types of things, because your blood, your brain needs proper blood sugar everything, your, all your cells need proper blood sugar, but your brain gives you the most notable symptoms. And when you're getting those symptoms, you are creating, there's a huge amount of inflammatory and what's called oxidative stress.

And so both of these chemical entities will then cause your antibodies to your thyroid to be attacked by inflammatory responses. And then, and then ultimately those inflammatory responses will attack your thyroid if you're a Hashimoto's patient. And then there's insulin resistance. So low blood sugar below 60 is, is what your medical doctor would be all excited about. But they're really not excited about low blood sugar. When you're getting ear and shaky and have anxiety and stuff, they just say, you know what? You just have anxiety in your ear will shaky here, take some, you know, take some Xanax or take some Prozac or take some sort of a, you know, anti-anxiety medication. They, and, and they'll look at your labs and, and if your blood labs are normal, but you have all of those symptoms, they're not gonna treat you for low blood sugar.

Here's a problem. Low blood sugar can, your low blood sugar can be present for seven to 10 years before it shows up on your blood test. So you really gotta go by these symptoms. Same thing with high blood sugar will use the terms, insulin resistance, because these are terms of doctors will use with you or prediabetic. Once you get the diabetes, your diabetic, you have high blood sugar, it stays a high until you do something about it.

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Can you be thin with hypothyroidism so that, you know, none of these direct questions are really all that straightforward. Okay. So hypothyroidism, first of all, the caveat is, is how many people actually have hypothyroidism. And the answer is almost very, very, very, very few. If you have a hyperthyroid and your thyroid slowing down the is why, why is your thyroid slowing down? And and, and so there are a lot of things that can affect thyroid function, but to actually put you in hypo thyroid to where your TSH number is to a point where your doctor pronounces you hypothyroid, usually there's going to have to be some reason that your thyroid has slowed down is not making enough thyroid hormone. And the vast majority of the time is because you have autoimmune thyroid disease and nobody's figured it out yet.

And so, so I think even the Mayo clinic now is saying that 85 to 95% of people who have autoimmune thyroid disease is actually Hashimoto's. And the reason that can happen is because it can take seven years, maybe, well, maybe it actually not even looking to see if you have autoimmune thyroid disease. And even if you have it, it can take like seven years from the time that it's triggered until the time that you start really seeing antibodies and you start seeing your thyroid hormone go off and then you can, and then you go through the only time, the only way you're thin is if you haven't had enough damage to your thyroid yet. And, and, and, and, and usually at that point in time, that was even when you're looking at thyroid problem, because usually your doctors, aren't gonna look at it, fired problem for you, unless you're fatigue and putting on weight.

And if you are thin and you have been diagnosed with hypothyroidism the greater likelihood is that you probably need to look further. You may be the thin Hashimoto's patient, about 10, 15% of people are thin with Hashimoto's with hyperthyroid HashChing with Hashimoto's hypothyroidism. But and, and, and if, and if that's you, in other words, you went to the doctor, your thyroid stimulating hormone is high, which means you were a hypo thyroid without getting into that whole thing. Then then you might want to, and you're wondering, you know, could I have Hashimoto's it's at that point, it's about it's about the symptoms. Are you having hyper symptoms? Cause hypo, thyroid slows everything down, I'm depressed, I'm fatigued. I'm putting on weight, my falling out my bowels don't work. I got constipation it's and, but if you were, but if you can't put on weight, if you're, if you have anxiety, panic attacks, if you have inward tremors, you have heart palpitations for no reason at all, some the night sweats, there's a good chance that you're the thin Hashimoto's patient, as opposed to the thin thyroid patient, which I don't even know if then hype.

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Insomnia and Hashimoto's, and I can't believe I haven't talked about this one yet. Because it's so huge. I mean, really sometimes when people will, you know, they'll say, okay, doc, you know, they know who I am or something like that. I'm talking to people and they're like, oh wow. I can't go to your pre three. You know, this can't go through your program or whatever. I can't, I can't do my diet or whatever. What's, what's like one of the one things you would have me change and really sleep is like way, way, way on top of the list of things that I would have them change relative to relative to their, their immune problem. I mean, if I put it right up there with gluten and I'd put it right up there with certain supplements that are really, really, really can be really powerful.

And auto-immunity, it's way up there because w when you get into REM sleep, when you get into that right sleep pattern it's, it's called restorative sleep, basically. That's when healing accelerates. So whatever you're doing with your diet and whatever you're doing during the day relative to your supplements, your diet, your other triggers, your, your exercise, you're not, over-training all these other things are, they kind of come together when you sleep. I, I is this for me, this, excuse me for me, this is like top, top, top. I strive to always get my sleep and I have to sleep more than eight hours. For those of you who have seen this for the first time, I have Hashimoto's and a number of other autoimmune issues. So I have to I have to sleep more than eight hours, and sometimes it's, it's a long time, so I make sure I get the bed early.

I make sure I get through the night. I make sure that when I wake up, I'm feeling refreshed. And if I'm not, I'll stay there until I am. I'll know when it, when it is. So there's not an exact number of hours for sleep for an automated patient probably is relative to how severe you are suffering, how many tissues are being damaged, sleep. So sleep is very restorative. It also is it's controlled by a part of your brain called the hippocampus the same part of your brain that is relative to short-term memory loss at the same, same area. Cause short-term memory. It turns into long-term memory when you sleep. So the same part of the brain is involved in your sleep. Rhythm sleep rhythm is huge. Circadian rhythm is huge. So I've had several patients over the years who have inconsistent work schedules.

So there's, there's, there's working normal day time, and then they switch over to a night shift and then they switch over the daytime and then they switch over to swing shift. I I'm in Reno, Nevada, where we have several casinos and casino workers will, will have that happen to them regularly. They start getting sick, they start getting injured. They can't think as well because it's, it's screwing up their brain and they're not getting the proper REM sleep. They're probably not getting the proper restorative sleep. So it, it makes them much more susceptible to getting sick.

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What causes Hashimoto's? I don't feel like maybe I've put out a succinct enough explanation of this. Just based on like, thinking back to some of the presentations I've made and, and, and I wanted to do this to either update or clarify that question for people Hashimoto's patients come into us. And back in the day before we knew a whole lot about Hashimoto's and how to determine if the person even had it the numbers were all over the place. Nobody knew what the ranges were. A lot of people still don't know what the ranges are. They're still all over the, I mean, I've talked to somebody in Alabama the other day where the range of zero to a hundred the Mayo clinic is now agreeing that the range is zero to nine.

I, in my city, there was a hospital zero to nine. There's another hospital, zero to 34, and there's another hospital to zero to 24. So there was a lot of confusion on that. And, and, and those types of things made it really challenging. So we went a lot on symptoms. And one of the things we started to recognize was if mom had a thyroid problem and the grandma had a thyroid problem and their sister had a thyroid problem, this person's probably got it. So we understood in the beginning that genetics was a big player. So, and then, and then there's the genetics. So we used to do the HLA DQ testing, and we would go, oh my God, you got the positive codes for it. You have it. And then now we know that that's not necessarily true. You can have the genetic code for it, not get it and not have it, so you can be treating it.

And for a lot of people out there who are still going by the genetics, there are a lot of doctors out there treating people by the genetics for things that they don't have, their thing there's things that they could have, but they don't have. So having said that genetics genetics are involved. You usually have to have one of the genes that say, you can get Hashimoto's to get Hashimoto's. So this is why you'll see it in your family. And if you've got it, you'll see your sister's got it. Or maybe your grandmother's got it. Great. Grandma's got it. Her brother, you know, and, and usually that's a prerequisite. There used to be like two genes that we talk about. I think it was the HLA B 27. I forgot what the other one was, because it was so long ago. Why do I forget it?

Because now there's 90 genes that are listed that indicate a vulnerability to Hashimoto's 90. So, so that doesn't mean you should go out and get genetic testing. Okay. It just means that if you really want to know the, cause there's been some sort of an evolutionary issue to where hypo thyroid are turning into into PR into problems. And maybe these genes have been there forever, but we haven't been doing the things that turn, turn it on. So so the things that make us more vulnerable to and that contribute to the expression of these genes is smoking. I mean, you're going to, I mean, you're going to get a lot of these things, but the reality is these are the things that make you vulnerable to these 90 genes being able to turn on smoking alcohol, you know, alcohol is one for sure a lack of selenium.

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Do you have to be gluten free with Hashimoto's? Yes. So yes, yes, yes, yes, yes, yes, yes, yes, yes. So, okay. Why? All right. So, you know, it's, it's interesting. Auto-Immunity is becoming now more and more understood and there's mechanisms that cause immune inflammation to spread. One of them was called epitope exp spreading one cause bystander spreading and other ones are have a topic sharing these epitopes and it's called and it's and it's part of something called molecular mimicry and all that means this. And this is pretty interesting actually. Y yes, yes, yes, yes, yes, yes, yes. There's this this molecular mimicry means that if you have an autoimmune problem, then, then there are multiple tissues in your body that may look to your immune system.

Exactly. Like the tissue that you're getting attacked. And then eventually as those attacks keep happening, your immune system looks around, sees that other tissue and can attack it. So let me give you a very solid example that if you're asking this question and you have Hashimoto's this will make sense to you. So the gluten protein of which are 25 different aspects to it has a metabolites on their epitopes metabolites. It has it has bio chemical material that looks to your immune system, exactly like metabolites that are in your thyroid. So we have a wheat protein. This is what is really interesting, and you have a thyroid endocrine tissue, a human and their current tissue. And you also have a the tissue in your cerebellum, which is, which is a part of your brain it's down here. And all you have to know for this presentation is when it's not working, it's dizziness, vertigo,

Balance, car sickness, boats, seasickness, stiff neck, blurred vision, and you've gone to the doctor and they've checked you for all that. And everything's normal. And your MRI is normal and your everything in your ears were normal and that's brain neurological tissue. And so you, so, so those tissues, brain tissue and the current tissue in a wheat protein all look exactly the same to your to your, to, to your immune system. So, so if you get Hashimoto's, you're going to get a sensitivity to gluten. If you have a gluten sensitivity, you're going to, you're going to get eventually Hashimoto's and, and frequently all three of these. So the person presents as maybe they've gotten off of gluten, maybe they haven't, maybe they've gotten off of gluten and said, you know, I, when I eat bread, I don't get as dizzy. What's that about? It's because they're, they're not getting that attack against the gluten and the cerebellum.

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So Hashimoto's and neuropathy is the topic today. The question of the day can they be connected? Yeah. 

So yeah, they can be connected note a fairly decent amount of the time. There's a lot of different types of neuropathy. Okay. Right now, I think they've lost count. I think they're up to like a hundred different causes of neuropathy, but they're small fiber off these there's mixed fiber and ROP these, and there's a large fiber neuropathies and the small fiber neuropathy. These are the ones that the Hashimoto's can be involved in. And these are sensory nerves. And you would know that you had small fiber neuropathy by the fact that you would get numbness, tingling, burning sharp shooting pains. These are, these are the small fibers being irritated by inflammation by the most common cause of those symptoms and the most common cause of small fiber neuropathy is pre-diabetes.

But one of the next most common causes of small fiber off the is Hashimoto's, which is an immune, which is autoimmune thyroid disease. And and really it's, it's comes from inflammatory responses that create thyroid dysfunction. And that affects just about everything in your system. But but the antibodies apparently can cross connect with with doing damage in your feet. There there's, there's, there's a couple of different crosses in this small fiber neuropathy. I think there's one of those hundred different things that can cause peripheral off. The only about eight are involved in causing small fiber neuropathy. And again, as I said, in some resistance pre-diabetes metabolic syndrome, whatever you want to call it. All of those are the most common cause I would say the second most common cause is probably the immune inflammation and that immune inflammation comes can come from.

Hashimoto's and then, and then Hashimoto's kinda cross reacts with gluten. So there's actually something called gluten sensitive, small fiber neuropathy which is you, you pray that you have this because you stop eating gluten, your peripheral neuropathy goes away and it has to do with different mechanisms that ultimately end up creating inflammation to the small fibers in your feet. The nice part about it, if you have Hashimoto's related small fiber neuropathy, the nice part about that is once you start to pull the triggers and get the immune responses against the Hashimoto's under control, a pretty significant amount of the time, percentage of the time that small fiber neuropathy will resolve. And and so, whereas that's not necessarily the case with the other neuropathies that we talked about in the beginning, the mixed fiber neuropathies tend to improve, but maybe not as much in the large fibers, they don't improve at all with with most of the things that, that you would try with diet and nutrition and lifestyle changes.

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