Concluding their Journey to the Centre of the Brain, Michael and Josh tackle one of the most challenging and difficult cancers in modern oncology: high-grade gliomas. All of the usual suspects are here: irrevocable, progressive disease, limited treatment options and a gulf in evidence so large it makes the Grand Canyon look like a muddy footprint. All in all, not the most optimistic of OftiM episodes, but Josh and Michael will tackle it anyway so you don't have to. And remember: always refer your fit GBM patients to a friendly neighbourhood trials unit near you!

Links to studies discussed in this episode (subscription may be required):

EORTC 26981-22981 NCIC CE3 (aka the “Stupp study"): https://www.nejm.org/doi/full/10.1056/nejmoa043330

RTOG 0825: https://www.nejm.org/doi/full/10.1056/nejmoa1308573

Brada et al: https://ascopubs.org/doi/full/10.1200/JCO.2009.27.1932?role=tab

Taal et al: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(14)70314-6/fulltext

Wick et al: https://www.nejm.org/doi/full/10.1056/nejmoa1707358

For more episodes, resources and blog posts, visit inquisitiveonc.com

Find us on Twitter @InquisitiveOnc

If you want us to look at a specific trial or subject, email us at [email protected]

Visit us at your new website www.inquisitiveonc.com for our latest episodes, links to resources and musings!

Art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Note: This podcast is for educational purposes only. If you are unwell seek medical advice

Hosted on Acast. See acast.com/privacy for more information.