In this episode, Nir Barzilai, director of the Institute for Aging Research and expert in the genetics of longevity, discusses the evidence that metformin and rapamycin have anti-aging properties and how his TAME study aims to support this hypothesis in humans. Additionally, he describes the role of genetics in lifespan/healthspan and how it might affect important pathways such as IGF and insulin sensitivity.

We discuss:

• Nir's background and interest in aging and endocrinology [3:30];
• History of metformin, and understanding the mechanism [11:15];
• Attempting to define insulin resistance [21:15];
• Metformin as a possible anti-aging drug [48:45];
• The TAME trial: Targeting Aging with MEtformin [57:45];
• Why Nir believes metformin can slow aging [1:16:30];
• The genetic gift of centenarians [1:28:00];
• IGF/GH and its impact on aging and chronic diseases [1:34:15];
• Genetics/epigenetics of centenarians, gene sequencing, CETP-VV, Lp(a) [1:49:15];
• Should you be taking HGH? [2:05:30];
• NAD and NAD precursors (NR and NMN) [2:30:00];
• Parting thoughts on metformin [2:36:15];
• Possible blind spots in Nir and Peter's thinking? [2:43:00]; and
• More.

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