SSRIs, antidepressants, and psilocybin–can you combine them? Many people are seeking an intentional psilocybin experience in order to combat depression, but very few know whether they can stay on their pharmaceutical medication or not. Some of these medications are medically contraindicated and some are not. 

Hosts Nicholas and Jimmy Nguyen address the various types of medications (not just antidepressants) and how they can impact the psychedelic experience. They provide some general guidelines as well as actionable advice for anyone who is currently taking prescription medication and considering a psychedelic journey. 

In this episode, the hosts discuss both the scientific studies and anecdotal evidence they’ve seen firsthand when it comes to combining antidepressants and psilocybin. They also highlight some of the profound shifts they’ve seen in their clients as well as how microdosing can help alleviate the withdrawal symptoms associated with tapering. 

Additional Resources:

• Episode Transcript
• Should I Stop Using Antidepressants for Psychedelic Therapy?
• The Psilocybin-Blunting Effects of SSRIs and Antidepressants
• Is it Safe to Take Psychedelics if You Have Suicidal Ideation?

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