Today we're going to be talking about a vitally important topic - intestinal permeability.  You may not have heard this term, but you likely have heard the term that's all over social media - leaky gut.  You guys are really gonna love this one.  This is part one in a two part series.  In next week's episode we will get more into testing for leaky gut and different management strategies. 

Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner.

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**Interesting articles for more information**

The Leaky Gut: Mechanisms, Measurement and Clinical Implications in Humans: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790068/pdf/nihms-1054015.pdf

All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases [version 1; peer review: 3 approved]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996528/pdf/f1000research-9-22543.pdf

Leaky Gut As a Danger Signal for Autoimmune Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440529/pdf/fimmu-08-00598.pdf

Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/pdf/nihms-1023086.pdf

The use of biomarkers associated with leaky gut as a diagnostic tool for early intervention in autism spectrum disorder: a systematic review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439029/pdf/13099_2021_Article_448.pdf

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders: https://www.frontiersin.org/articles/10.3389/fcimb.2020.00248/full

Is There an Exercise-Intensity Threshold Capable of Avoiding the Leaky Gut?: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982409/pdf/fnut-08-627289.pdf

Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188184/

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604320/pdf/fncel-09-00392.pdf

Intestinal Microbiome, Akkermansia muciniphila, and Medical Nutrition Therapy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145007/pdf/14-16.pdf