Elena F. Verdu, MD, PhD, co-author of new research on the role of the serine protease inhibitor elafin in celiac disease published in the May 2014 issue of AJG, talks with AJG Co-Editor Dr. William D. Chey about the pathophysiology of celiac disease, the role of various serine proteases, including elafin, in the inflammatory processes of celiac disease, and the potential diagnostic and treatment implications of the study findings. (15:37)

Christina M. Surawicz, MD, MACG, author and presenter of the J. Edward Berk Distinguished Lecture at ACG 2013, which was published in the April 2014 issue of AJG, talks with AJG Co-Editor Dr. Paul Moayyedi about physician burnout, which has been defined as "a state of mental exhaustion caused by one's professional life." She discusses the components of burnout (namely emotional exhaustion, depersonalization, and a decreased sense of personal accomplishment), frequent contributing factors to burnout such as work-home conflicts, and suggestions for how to prevent and manage burnout if it occurs. (21:00)

Nicholas J. Shaheen, MD, MPH , author of an editorial on a recent article on esophageal adenocarcinoma trends across three nations published in the March 2014 issue of AJG, talks with AJG Co-Editor Dr. William Chey about the rising incidence of esophageal adenocarcinoma, the most important and interesting conclusions drawn from this ecological study, and the role that GERD, Barrett's esophagus, tobacco smoking, alcohol consumption, and obesity all play in the pathogenesis of this disease.

Jeffrey M. Lackner, PsyD, co-author of new research on the correlation between self-ratings of health and IBS symptom severity published in the February 2014 issue of AJG, talks with AJG Co-Editor Dr. Paul Moayyedi about how fatigue, somatization, and negative social interactions might serve as key predictors for self-rated health in IBS, how IBS symptom severity has a surprisingly modest role in self-rated health, and how doctors can better consider the psychological experience of IBS and how that impacts treatment and patient response.

Robin C. Spiller, MD, FRCP, co-author of new research on the effect of FODMAPs such as fructose and fructans on irritable bowel syndrome (IBS) symptoms published in January 2014 issue of AJG, talks with AJG co-Editor Dr. William D. Chey about the dietary substances included in the FODMAP classification, the MRI imaging techniques used to measure FODMAP impact on colonic distention and gas production in this study, and how clinicians might consider FODMAPs along with gluten and lactose when recommending dietary interventions for IBS patients.

Evan S. Dellon, MD, MPH, co-author of new research on the distinguishing features of PPI-responsive esophageal eosinophilia and eosinophilic esophagitis (EoE) published in December issue of AJG, talks with AJG co-Editor Dr. Paul Moayyedi about the clinical features evaluated in the study, the lack of significant distinguishing association of these features to either disease, the role of PPIs in reducing eosinophils, and potential future studies worthy of pursuit in this area.

David A. Johnson, MD, FACG, co-author of new research on the emerging impact of online patient evaluation websites (PEWs) published in the Red Section of the November issue of AJG, talks with AJG co-Editor William D. Chey, MD, FACG, about the rating metrics used by these websites, the characteristics of typical users, and the potential ways in which physicians can interact with these sites to improve doctor-patient communication and manage their online reputation.

Sieglinde Angelberger, MD, and David Berry, PhD, co-authors of new research on the efficacy of fecal microbiota transplantation (FMT) in patients with ulcerative colitis published in the October issue of AJG, talk with AJG co-Editor Dr. Paul Moayyedi about the highlights of their case series, including choice of stool donors, route and duration of administration, impact of FMT on these patients' gut microbiota, and what the disappointing response to FMT in these ulcerative colitis cases suggests for further research into this practice.

Scott Tenner, MD, MPH, FACG, co-author of the American College of Gastroenterology's new Clinical Guideline on the Management of Acute Pancreatitis, published in the September issue of AJG, talks with co-Editor Dr. William Chey about the increasing prevalence of acute pancreatitis; the appropriateness of CT, MR, ERCP, and genetic testing in diagnosis of the disease; and the role of antibiotics, re-feeding, surgical debridement, and lactated ringer's solution versus normal saline in the management of acute pancreatitis.

Alberto Rubio-Tapia, MD, co-author of the American College of Gastroenterology Clinical Guideline for the Diagnosis and Management of Celiac Disease, discusses the key components of the guidelines with Associate Editor Max Schmulson, MD.