Two downsides of PFA including autonomic tone and hemolysis, a bad surrogate in AF care, and controversies in defining cardiac risk are the topics John Mandrola, MD, covers in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I.PFA and Its (lack of) Effect on Autonomic Tone

Pulsed Field Ablation for AF: Are US Electrophysiologists Too Easily Impressed?

https://www.medscape.com/viewarticle/pulsed-field-ablation-af-are-us-electrophysiologists-too-2024a1000d2v

• Autonomic Tone Paper https://doi.org/10.1016/j.jacep.2024.05.005
• ADVENT https://www.nejm.org/doi/full/10.1056/NEJMoa2307291

II. Second PFA Study JACC-EP—on Hemolysis  

• Hemolysis study https://doi.org/10.1016/j.jacep.2024.05.001
• MANIFEST 17K https://www.nature.com/articles/s41591-024-03114-3
• Defaye Editorial https://www.jacc.org/doi/abs/10.1016/j.jacep.2024.06.007

III. A Self-serving Surrogate Marker:  Diagnosis to Ablation Time.

• CAPLA Study https://jamanetwork.com/journals/jama/fullarticle/2800186
• CAPLA Substudy https://doi.org/10.1016/j.jacep.2024.05.031
• EHJ RCT Early vs Late https://doi.org/10.1093/eurheartj/ehad247
• LOOP; Diederichsen and colleagues  10.1016/j.jacc.2019.09.050
• Groningen and Maastricht Group study https://heart.bmj.com/content/109/3/186

IV. Future Cardiac Risk

• Diao and colleagues Study of AHA PREVENT Risk Equations https://jamanetwork.com/journals/jama/fullarticle/2821624
• JAMA Editorial https://jamanetwork.com/journals/jama/fullarticle/2821542
• Another JAMA Editorial https://jamanetwork.com/journals/jama/fullarticle/2821628

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