Suicidal ideation and GLP-1 agonists, a repeat of PARADIGM HF in Chagas CM, CASTLE HTx critical appraisal, and primary prevention of SCD in HF are the topics John Mandrola, MD, covers this week.

This podcast is intended for healthcare professionals only.

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I. Suicidal ideation with GLP-1

Signal of Suicidality With GLP-1 RA Semaglutide, but Experts Urge Caution

https://www.medscape.com/viewarticle/signal-suicidality-glp-1-ra-semaglutide-experts-urge-caution-2024a1000fa7

• Disproportionality Analysis from World Health Organization Data on Semaglutide, Liraglutide, and Suicidality
• Variability in Disproportionality paper https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.668765/full

II. PARACHUTE HF: Repeating the Mistakes in PARADIGM HF

• PARACHUTE HF https://www.jacc.org/doi/10.1016/j.jchf.2024.05.021
• SOLVD https://www.nejm.org/doi/full/10.1056/NEJM199108013250501
• CONSENSUS trial https://www.nejm.org/doi/full/10.1056/NEJM198706043162301
• Meta-analysis of Low vs High Dose ACE/ARB https://doi.org/10.1161/CIRCHEARTFAILURE.117.003956
• Meta-analysis of Sac/Val vs ARB/ACE Inhibitors https://link.springer.com/article/10.1007/s00228-024-03686-6
• PARADISE MI https://www.nejm.org/doi/full/10.1056/NEJMoa2104508

III. CASTLE HTx Critical Appraisal

• Critical Appraisal of CASTLE HTx https://doi.org/10.1016/j.jacc.2024.06.020
• CASTLE HTx https://www.nejm.org/doi/10.1056/NEJMoa2306037
• CASTLE AF https://www.nejm.org/doi/full/10.1056/NEJMoa1707855

IV. More Data Suggesting Modest Benefits of the Primary Prevention ICD

• First and Recurrent ICD Shocks: JICE Paper from Denmark https://link.springer.com/article/10.1007/s10840-024-01873-0
• HF trialists https://www.nejm.org/doi/full/10.1056/NEJMoa1609758 PROFID Trial https://profid-project.eu/
• DANISH https://www.nejm.org/doi/full/10.1056/NEJMoa1608029
• SCD-HeFT https://www.nejm.org/doi/full/10.1056/NEJMoa043399

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