On this episode, I discuss benzonatate pharmacology, adverse reactions, and much more.

Tessalon Pearls (benzonatate) are a non-narcotic antitussive commonly prescribed to relieve dry, non-productive coughs.

Benzonatate acts by numbing stretch receptors in the respiratory tract, lungs, and pleura, which helps suppress the cough reflex at its source. Unlike opioid-based cough suppressants, it doesn’t work in the brain’s cough center.

The usual adult dose is 100 to 200 mg taken orally three times a day as needed, with a maximum daily dose of 600 mg.

One of the most critical points is that the capsules must be swallowed whole. Chewing, sucking, or crushing them can cause numbness in the mouth and throat, leading to a risk of choking or aspiration.

There are no major drug interactions associated with benzonatate.

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