Brain Inspired

BI 224 Dan Nicholson: Schrödinger’s What is Life? Revisited


Listen Later

Support the show to get full episodes, full archive, and join the Discord community.

The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for Brain Inspired email alerts to be notified every time a new Brain Inspired episode is released.

To explore more neuroscience news and perspectives, visit thetransmitter.org.

My guest today is Dan Nicholson, Assistant Professor of Philosophy at George Mason University, here to talk about his little book, What Is Life? Revisited. Erwin Schrödinger's What Is Life is a famous book that people point to as having predicted DNA and influenced and inspired many well-known biologists ushering in the molecular biology revolution. But Schrödinger was a physicist, not a biologist, and he spent very little time and effort toward understanding biology.

What was he up to, why did he write this "famous little book"? Schrödinger had an agenda, a physics agenda. He wanted to save the older deterministic version of quantum physics from the new indeterministic version. When Dan was on the podcast a few years ago, we talked about the machine view of biological systems, how everything has become a "mechanism", and how that view fails to capture what modern science is actually telling us, that organisms are unlike machines in important ways. That work of Dan's led him down this path to Schrödinger's What Is Life, which he argues was a major contributor to that machine metaphor so ubiquitous today in biology. One of the reasons I'm interested in this kind of work is because the cognitive sciences, including neuroscience and artificial intelligence, inherited this mechanistic perspective, and swallowed it so hard that if you don't include the word "mechanism" in your research paper, you're vastly decreasing your chances of getting your work published, when in fact the mechanistic perspective is one super useful perspective among many.

  • Dan’s website. Google Scholar.
  • Social: @NicholsonHPBio; @djnicholson.bsky.social
  • What Is Life? Revisited
  • Previous episode:
    • BI 150 Dan Nicholson: Machines, Organisms, Processes
    • Read the transcript.

      0:00 - Intro

      7:27 - Why Schrodinger wrote What is Life
      15:13 - Aperiodic crystal and the meaning of code
      21:39 - Order-from-order, order-from-disorder
      28:32 - Appeal to authority
      37:48 - Cell as machine
      39:33 - Relation between DNA and organism (development)
      44:44 - Negentropy
      53:54 - Original contributions
      58:54 - Mechanistic metaphor in neuroscience
      1:16:05 - What's the lesson?
      1:28:06 - Historical sleuthing
      1:39:49 - Modern philosophy of biology

      ...more
      View all episodesView all episodes
      Download on the App Store

      Brain InspiredBy Paul Middlebrooks

      • 4.8
      • 4.8
      • 4.8
      • 4.8
      • 4.8

      4.8

      134 ratings


      More shows like Brain Inspired

      View all
      Very Bad Wizards by Tamler Sommers & David Pizarro

      Very Bad Wizards

      2,676 Listeners

      Making Sense with Sam Harris by Sam Harris

      Making Sense with Sam Harris

      26,344 Listeners

      Conversations with Tyler by Mercatus Center at George Mason University

      Conversations with Tyler

      2,451 Listeners

      The Quanta Podcast by Quanta Magazine

      The Quanta Podcast

      529 Listeners

      Closer To Truth by Closer To Truth

      Closer To Truth

      246 Listeners

      The Michael Shermer Show by Michael Shermer

      The Michael Shermer Show

      935 Listeners

      Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas by Sean Carroll | Wondery

      Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

      4,187 Listeners

      The Origins Podcast with Lawrence Krauss by Lawrence M. Krauss

      The Origins Podcast with Lawrence Krauss

      509 Listeners

      Google DeepMind: The Podcast by Hannah Fry

      Google DeepMind: The Podcast

      200 Listeners

      Last Week in AI by Skynet Today

      Last Week in AI

      305 Listeners

      Machine Learning Street Talk (MLST) by Machine Learning Street Talk (MLST)

      Machine Learning Street Talk (MLST)

      95 Listeners

      Dwarkesh Podcast by Dwarkesh Patel

      Dwarkesh Podcast

      503 Listeners

      Theories of Everything with Curt Jaimungal by Theories of Everything

      Theories of Everything with Curt Jaimungal

      24 Listeners

      Clearer Thinking with Spencer Greenberg by Spencer Greenberg

      Clearer Thinking with Spencer Greenberg

      138 Listeners

      Robinson's Podcast by Robinson Erhardt

      Robinson's Podcast

      263 Listeners