Comorbidities are common and important in all countries around the world. They have a significant impact on patients and healthcare providers. The BMJ Best Practice Comorbidities Manager has been designed to help healthcare professionals better manage patients with common combinations of comorbidities. This BMJ Best Practice podcast is an interview with Professor Neera Ahuja, Professor of Medicine, Associate Chief Medical Officer and Senior Vice President at Stanford Healthcare. Competing interests: NA has received honoraria for editorial work on BMJ Best Practice