Go online to PeerView.com/VTJ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. The therapeutic landscape for bladder cancer has rapidly evolved. The largely chemotherapy-based approaches of the past are giving way to the use of immune checkpoint inhibitors, targeted agents, and antibody–drug conjugates in advanced disease, as well as bladder-sparing and perioperative approaches in early-stage disease settings. How can oncology nurses synthesize the diverse body of clinical evidence on approved and emerging strategies into the realities of real-world cancer care to successfully address the therapeutic and educational needs of patients across the disease continuum? To help nurses rise to the challenge of modern bladder cancer management, this PeerView activity, based on a recent live event and developed in collaboration with the Bladder Cancer Advocacy Network, features an interprofessional expert panel that provides overview of the rationale and clinical evidence supporting the use of targeted, immunotherapeutic, and antibody-based strategies in bladder cancer. The panel also offers in-depth guidance on safe and effective integration of guideline-recommended therapies into personalized patient care and strategies to mitigate and manage adverse reactions and effectively support patients. Upon completion of this activity, participants should be better able to: Summarize new evidence on therapeutic strategies for bladder cancer management based on innovative drug delivery approaches, modern immunotherapy regimens, and targeted agents across the disease continuum; Develop educational strategies related to therapeutic expectations and safety considerations to enhance quality of life for patients with varying stages of bladder cancer; and Incorporate evidence- and team-based management and nursing protocols to address the unique suite of adverse events associated with approved and emerging therapeutics for bladder cancer