Cannabis and Tolerance -2025 edition!

In this week’s annual refresher, we dive into the science and strategy behind cannabis tolerance. Ryan breaks down how THC tolerance develops, what’s happening at the receptor level of your endocannabinoid system, and why managing it is key to keeping cannabis effective. You’ll learn practical, research-backed tips like microdosing, rotating strains, incorporating CBD, and taking tolerance breaks—so you can enjoy cannabis more mindfully, affordably, and with greater impact. Whether you’re a daily user or a casual consumer, this episode will help you keep the magic alive.

Research:

CBD and Your Endocannabinoid System: How it Works | Amy Myers MD

Pharmaceuticals | Free Full-Text | Endocannabinoid System: Chemical Characteristics and Biological Activity

IJMS | Free Full-Text | Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

The 7 most important cannabis research studies of 2023 | Leafly

Info:

Cannabis Connoisseur Podcast Info:

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Youtube: https://www.youtube.com/watch?v=7BRwpUrBgQM&t=5s

“Disclaimer: The content provided in this podcast is for informational purposes only and should Not be considered medical advice. The hosts and guests are not medical professionals, and their opinions are based on personal research and experiences. It is always recommended to consult with a qualified healthcare professional before making any medical decisions or changes to your treatment plan. This podcast does not endorse or promote the use of cannabis for medical purposes without the supervision of a licensed healthcare provider.”

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