Charting Pediatrics

For many practicing doctors today, advancements in science currently unfolding seemed futuristic during their years of training. Fetal care and in utero surgery are at the forefront of these advancements. Specifically, over the last 50 years, growth of maternal-fetal medicine and the importance of fetal care centers have grown exponentially. Medical evolutions have paved the way for specialists to treat an unborn child as a separate patient, offering life-saving care before birth.

Our team at Children's Hospital Colorado has performed more than 1,600 surgeries, making us one of the most experienced fetal centers in the country. That's why this week we are thrilled to welcome Sarkis (Chris) Derderian, MD, as our guest on Charting Pediatrics. As an expert in this field, he is currently an assistant professor of surgery and a pediatric surgeon at Children's Colorado, but his passion for fetal care began during his medical school years. "It was actually trauma that looped me into pediatric surgery and that I remember a 3-month-old baby that was in a car accident, terribly sick at the time, but at the time I left that rotation that baby was up moving around and it was just really a reflection of how resilient this population is," Dr. Derderian says.

Throughout this episode we dive into what fetal surgery currently looks like and how its progression gives as a look inside what the next 50 years could look like. "I think it's going to be revolutionary what we can do," Dr. Derderian says. It's a space that's pushing the envelope to provide a new quality of life.

Some highlights of today's episode include:

· Conditions being intervened by fetal surgery

· Diagnosing disease processes early in gestation

· How concepts like animation help make information digestible for families

· The future potential of fetal surgery

For more information on Children's Hospital Colorado, visit: childrenscolorado.org

Welcome back to another exciting season of Charting Pediatrics! For our long-time listeners, we are thrilled to have you back, and for anyone new to our audience, we couldn't be more excited that you've joined us. In this first episode of Season 7, we dive into the world of Type 1 diabetes (T1D). Did you know that one in 300 individuals under the age of 20 is affected by this condition? Our guest on today's episode, Kimber Simmons, MD, isn't just an expert in her field; she was a part of that statistic after getting diagnosed at just 8 –years old. Now, as an associate professor of pediatrics and pediatric endocrinology, as well as a pediatric endocrinologist at Children's Hospital Colorado and the Barbara Davis Center for Diabetes, she's shedding light on some of the latest research.

Dr. Simmons and other experts explain alternative approaches that modify the natural course of T1D, rather than solely treating hyperglycemia, could dramatically improve both the quality of life and health outcomes for patients. In this episode, we review strategies for early diagnosis of T1D that predict, as well as prevent or delay, the onset of clinical T1D during preclinical stages of the disease. We also discuss an exciting new medication, Tzield (teplizumab-mzwv), with the promise of delaying the onset of clinical disease in T1D. "It is going to shift how we manage Type 1 diabetes in the future," Dr. Simmons says.

Some highlights from today's episode include:

• How the predictability of T1D has changed over the years

• Expansion of screening programs worldwide

• New breakthrough medication, Tzield (teplizumab-mzwv), approved in the U.S. to delay the onset of clinical T1D

• Children's Colorado program to help providers identify the disease and follow up

For more information on Children's Hospital Colorado, visit: childrenscolorado.org

It's time to jump back into the ever evolving world of pediatrics. On this new season of Charting Pediatrics, one of the top 5 pediatric podcasts in the world, we expand our horizons, discuss cutting edge research and cover hot topics among the medical community. Season 7 will push new boundaries, answer lingering questions and take us on the road for in person interactions. Get ready for August 29th, it's a season you won't want to miss.

For more information on Children's Hospital Colorado, visit: childrenscolorado.org .

In this episode, we discuss food allergy, a very important topic for the general pediatrics community. Matthew Greenhawt, MD, joins us for this discussion as an expert in pediatric allergy and a leader of pioneering international studies looking at how we treat life- threatening food allergies in kids.

Guest:

Dr. Matthew Greenhawt specializes in pediatric allergy and immunology and is the director of the Food Challenge and Research Unit at Children's Hospital Colorado.

For more information on Children's Hospital Colorado, visit: childrenscolorado.org

Imagine you have a new 13-year-old patient in your practice. When you perform a return-to-school physical examination, you notice healed linear cutting marks on both of their wrists. The remainder of your exam is normal. In light of this finding, what are your next steps? What questions should you be asking the family and the patient, and what should you be concerned about today?

As part of our mental health series, in this episode we discuss nonsuicidal self-injury (NSSI). This is a common problem in teenagers and young adults, with some studies estimating a prevalence of up to 18% in high school students. Considered a developmental-timed problem, NSSI becomes much less common with age. Which begs the question, what's happening inside that teenage brain? Two Children's Hospital Colorado experts join us to help decode what is going on.

Guests:

Evadine Codd, PhD, is a licensed psychologist at Children's Colorado within the Pediatric Mental Health Institute.

Luke Miller, MD, is a child and adolescent psychiatrist at Children's Colorado.

For more information on Children's Hospital Colorado, visit: childrenscolorado.org

The important but ever-elusive goal of work-life balance is still more out of reach for women than men. Studies of home workloads for physicians indicate that the bulk of the nonprofessional work at home still falls to women. As a result, female physicians experience more work-family conflict than their male counterparts. This dynamic can lead to decreased job satisfaction, fewer women seeking professional advancement and increased burnout. In this episode, we talk with Children's Hospital Colorado experts about their research in the area of work-life balance for female interventional radiologists.

Guests:

Jenny Zablah Alabi, MD, an associate professor of pediatrics and interventional cardiology at the University of Colorado School of Medicine, and a pediatric cardiologist at Children's Colorado.

Natalie Soszyn, MD, a second-year fellow in interventional cardiology at Children's Colorado.

This episode is underwritten by Aegon Transamerica Foundation, a proud supporter of Charting Pediatrics and Children's Hospital Colorado. The Aegon Transamerica Foundation helps build a better world by committing to the improvement of wellness throughout their communities. Their partnership with Children's Colorado addresses the youth mental health crisis to help create a better mental health future for children. Thank you to Aegon Transamerica Foundation for investing in Children's Colorado.

For more information on Children's Hospital Colorado, visit: childrenscolorado

Resource: Work-Life Balance: The Expectations and Perspectives as a Female Interventional Cardiologist

The gut microbiome is a fascinating area of human health that we just started to better understand in the last two decades. With the arrival of PCR sequencing and advanced PCR techniques, we've been able to characterize the microbiome by looking at what organisms live there and how they vary by location and diet, as well as how the microbiome is influenced by things like exposure to antibiotics. We're beginning to understand the relationship between the microbiome and health, from how these bacteria influence human metabolism and immune system development to their association with autoimmune diseases. Although we've learned a great deal, there's still a lot for us to understand about our microbiome, including the relationship between our nervous system and the bacteria in our gut. In this episode, we'll explore what we know and what we have left to discover with our guest Jaime Belkind-Gerson, MD.

Guest:

Jaime Belkind-Gerson, MD, is a pediatric gastroenterologist at Children's Hospital Colorado. Dr. Belkind-Gerson is an expert in neurogastroenterology and gastrointestinal motility, and he's an associate professor of pediatrics at the University of Colorado School of Medicine.

For more information on Children's Hospital Colorado, visit: childrenscolorado.org

One of the most concerning trends in child health is the increase in suicide rates over the last two decades in the United States. Suicide is the second leading cause of death in teenagers and young adults, and we should be alarmed both as pediatricians and citizens. We also need to ask questions about what this says about our society, what kind of promise and opportunity kids see for themselves, whether they are receiving the support they need, and if our healthcare system has the capacity to manage kids before and during a mental health crisis. As part of our ongoing mental health series, in this episode we discuss the alarming increase in suicide rates and some potential solutions to prevent suicide in children.

Guests:

Lisa Horowitz, PhD, MPH, is a pediatric psychologist and senior associate scientist at the National Institute of Mental Health (NIMH) Intramural Research Program at the National Institutes of Health in Bethesda, Maryland, and is a principal investigator at the NIMH studying detection of suicide risk in the medical setting.

Jeff Bridge, PhD, is an epidemiologist and director of the Center for Suicide Prevention and Research in the Abigail Wexner Research Institute at Nationwide Children's Hospital in Columbus, Ohio. He is also the Nationwide Foundation Endowed Chair of Innovation in Behavioral Health Research and professor of pediatrics, psychiatry and behavioral health at The Ohio State University College of Medicine.

Today's episode is underwritten by Modivcare Foundation, a proud supporter of Charting Pediatrics and Children's Hospital Colorado. The Modivcare Foundation is committed to improving the health of their members in communities across the country while advocating for the future of care through philanthropic funding. Their partnership allows Children's Colorado to make important changes to our state's mental health system, prevent suicide, and give youth the support and services they need to thrive. Thank you to Modivcare Foundation for your investment in Children's Hospital Colorado.

For more information on Children's Hospital Colorado, visit: childrenscolorado.org

It is not uncommon for newborn babies to have slight imperfections in their heads. Most of the time, these imperfections will fix themselves over time, or once they begin to develop. However, sometimes a more serious diagnosis will require medical interventions. Craniosynostosis is a condition where a baby's skull begins to fuse together too early. This occurs at birth or shortly after and if not treated, can affect brain development.

Guests: Dr. Brooke French and Dr. Allyson Alexander. Dr Allyson is a Pediatric Neurosurgeon here at Children's Hospital Colorado and is also an Assistant Professor at University of Colorado School of Medicine. Dr. Brooke French is the Co – Director of Cleft and Craniofacial Surgery Programs and is also the Director of Cosmetic Surgery here at Children's Hospital Colorado.

For more information on Children's Hospital Colorado, visit: childrenscolorado.org

Sudden unexplained infant death, commonly known SUID, SIDS or crib death, affects approximately 3,400 infants each year. Sudden unexpected infant deaths usually occur when an infant is sleeping, and causes can include suffocation, unknown infection, ingestion and other unknown causes. Not only has there been minimal improvement in rates of sleep-related deaths over the past two decades, but racial and ethnic disparities in SUID persist, including increased mortality rates. These disparities are indicative of the broader landscape of inequities within our healthcare systems. Today, we are talking about how providers and healthcare professionals can educate families and help them catch early signs of SUID.

Guests: Sunah Hwang, MD, is a neonatologist at Children's Hospital Colorado and an associate professor of pediatrics at the University of Colorado School of Medicine. Aniekan Udoko, MD is a neonatal-perinatal medicine fellow at Children's Hospital Colorado.

For more information on Children's Hospital Colorado, visit: childrenscolorado.org