US doc's pay, the ticagrelor controversy and new RCTs, clopidogrel beats ASA, holding antiplatelets for non-cardiac surgery, and Prof Cleland and ASA dogma are the topics John Mandrola, MD, covers this week.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. US Healthcare

Mandrola's Top 10 Stories in 2024 https://www.medscape.com/viewarticle/mandrolas-top-10-stories-2024-2024a1000mxe?_gl=1*dcvmkh*_gcl_au*MTgzOTY2ODQ0Ni4xNzI5MjU4NjUz

• CMS Proposal

II. Ticagrelor Controversy

New Investigation Casts Doubt on Landmark Ticagrelor Trial

https://www.medscape.com/viewarticle/new-investigation-casts-doubt-landmark-ticagrelor-trial-2024a1000n1d

• Doshi Review https://www.bmj.com/content/387/bmj.q2550
• PLATO https://www.nejm.org/doi/full/10.1056/NEJMoa0904327
• ISAR REACT 5 https://www.nejm.org/doi/full/10.1056/NEJMoa1908973
• Bates Review https://www.ahajournals.org/doi/epub/10.1161/JAHA.123.031606
• Victor Serebuany and Dan Atar Editorial https://doi.org/10.1093/eurheartj/ehp545

III. New Ticagrelor vs Clopdiogrel trial

• Preprint: https://www.medrxiv.org/content/10.1101/2024.11.06.24316875v1.full-text

IV. Clopidogrel Better Than ASA Even in HBR

• Substudy Long-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity
• HOST-EXAM 10.1016/S0140-6736(21)01063-1
• HOST-EXAM-Extended https://doi.org/10.1161/CIRCULATIONAHA.122.062770

V. ASA During Non-Cardiac Surgery

• ASSURE DES https://doi.org/10.1016/j.jacc.2024.08.024

VII. Professor Cleland on ASA for Secondary Prevention

• Cleland Editorial https//jamanetwork.com/journals/jamacardiology/article-abstract/2827201
• ASA Meta-analysis 10.1016/S0140-6736(09)60503-1
• AMIS https://jamanetwork.com/journals/jama/fullarticle/368745
• SAPAT 10.1016/0140-6736(92)92619-Q

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