Do you know if you're harboring silent inflammation?  An easily available blood test will tell you.

In this episode, Dr. Gordon and I discuss a few of our favorite and unusual medical tests, including how to predict longevity from a measure of grip strength and a special test of living blood cells that shows how well a patient can resist cancer growth. 

• Why the health of your smallest blood vessels dictates your overall health and longevity picture, and how to measure this. 
  
  
• How your "natural killer cells" are related to cancer, and the special blood test that can measure the fitness of these cells. 
  
  
• Why medicinal mushrooms enhance health.

And much more. 

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

In this episode, Dr. Gordon discusses her recently published pilot trial in which she and three physician colleagues successfully treated patients with dementia. 

• Evaluating cognitive impairment: subjective vs measurable? 
• Distinguishing mild cognitive impairment from early Alzheimer's dementia
• Which interventions actually moved the needle? 

 Along the way, we dive into details on mechanisms.

Time stamps with links to references and resources:

11:51     Chewing enhances brain health 

13:59    observational study of 10 patients with dementia undergoing lifestyle intervention “Reversal of cognitive decline:  A novel therapeutic program.” 

15:11     CNS-Vital Signs test  

22:29    Hormesis

23:24     Intellxx DNA testing  https://www.intellxxdna.com/ 

29:46     Cyrex testing

36:00   Study: Do US patients on colon cancer chemotherapy have more side effects due to increased amounts of folic acid in enriched foods? 

39:50     Link to Dr Gordon’s mold you tube talk  

41:15     Link to Dr. Gordon's recent research “Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project” in Journal of Alzheimer’s Disease, 2022; 88(4): 1411-1421.

46:52    Finland and Iceland high rates of AD    
and
“Why Does Finland have the highest dementia mortality rate?"

47:10     Online resources for people who are still functioning very well, but believe themselves at risk for dementia

·        BrainHQ 

·        Brainjo

·        Food for the Brain

Resources for a more intensive therapeutic approach

·      Apollo Health 

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Episode 4 Hormones

 In this episode, Dr. Gordon discusses female hormones. She gives us a glimpse into their function and what happens to aging women as they lose those hormones in menopause. She also talks about the skillful use of hormone replacement to extend life and enhance its quality. For those women who don’t or can’t take the typical form of hormone replacement therapy,  she describes workarounds for benefit of both brain and bone health.

Links to references and more reading on some of the topics mentioned:

1.  Increased Alzheimer’s Risk During the Menopause Transition

2.  Mercury and Lead toxicity in menopause-induced osteopenia

3.  Estrogen receptors are complicated, we'll address in a future episode, but here's a brief, layman's terms summary.

4.  Comprehensive genetics testing provider, IntellxxDNA

5.  Hormone replacement therapy  prescribed for women aged 57-82 was associated with a significant improvement in tests of cognitive function at 24 months.   

6.  Testing estrogen metabolites in the urine.   

7.  Foods included in a conventional Polish diet—cabbage and sauerkraut—are associated with a reduced risk of breast cancer in Polish migrant workers.

8.   Genistein can confer protection against bone loss  and is emerging as a therapeutic option against the pathogenesis of memory impairment.  

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains

Have you ever wondered why some cancer patients unexpectedly recover?  

In this episode, Drs. Lemanne and Gordon discuss the cases of four persons who survived a range of cancer diagnoses considered universally terminal. But instead of dying promptly, two left hospice to return to active, athletic lives for several years. Two others defied all odds to achieve apparent cures.  These four patients used radically different approaches.

The four diagnoses include chronic lymphocytic leukemia (CLL), advanced ovarian cancer, metastatic prostate cancer, and metastatic melanoma.

Several surprising ideas that come up in this episode include why having chemotherapy before surgery is often better than rushing to surgery, and how the principles of evolution (as in Darwin) are pointing to lighter, more infrequent cancer treatments as a way to prolong both healthspan and lifespan. 

Links, Episode 1:

 1. MIT research demonstrating the detrimental effect of surgery on cancer metastasis.

2. How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence. 

3. N of 1,  by Glenn Sabin and Dawn Lemanne, MD, MPH.  The popular book about Mr. Sabin's successful search for a cure for his "incurable" chronic lymphocytic leukemia. 

4. Case report of durable CLL remission without standard systemic therapy: Lemanne D, Block KI, Kressel BR, Sukhatme VP, White JD. A Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea. 

5. Research demonstrating that maximal PSA suppression may be detrimental in advanced prostate cancer.

Dawn Lemanne, MD
Oregon Integrative Oncology
Leave no stone unturned.

Deborah Gordon, MD
Northwest Wellness and Memory Center
Building Healthy Brains