FoundMyFitness

Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation


Listen Later

Dr. Guido Kroemer is a professor at the University of Paris Descartes and an expert in immunology, cancer biology, aging, and autophagy. He is one of the most highly cited authors in the field of cell biology and was the most highly cited cell biologist for the period between 2007 and 2013. Especially notable among his contributions: he was the first to discover that the permeabilization of mitochondrial membranes is a concrete step towards apoptotic cell death.

This episode is decidedly focused on autophagy, an important cellular program that is inducible by dietary fasting and has broad implications for aging and cancer. Autophagy discussion includes:

  • How the 3 main signals that activate autophagy all involve nutrient sensing (00:09:09).
  • The role of different types of fasting and nutrient deprivation in autophagy (00:20:55).
  • How different types of exercise can induce autophagy (00:24:35).
  • How a specific type of autophagy called mitophagy keeps mitochondria healthy (00:36:29).
  • How autophagy has been shown to slow cellular aging (00:33:07).
  • How autophagy prevents neurodegenerative diseases by clearing away protein aggregates (00:39:38).
  • The role of autophagy in cancer as a possible double-edged sword (00:48:29).
  • How certain compounds known as caloric restriction mimetics (or fasting mimetics) including resveratrol, spermidine, hydroxycitrate can induce autophagy by tricking the cell through the modulation of one or more of the 3 main autophagy signaling pathways (00:54:52).

Visit Dr. Guido Kroemer's website.

Did you enjoy this podcast? It was brought to you by people like you!
Click here to visit our crowdsponsor page where you can learn more about how you can support the podcast for as little or as much as you like.

Watch the full video on YouTube.

...more
View all episodesView all episodes
Download on the App Store

FoundMyFitnessBy Rhonda Patrick, Ph.D.

  • 4.8
  • 4.8
  • 4.8
  • 4.8
  • 4.8

4.8

5,171 ratings


More shows like FoundMyFitness

View all
Boundless Life by Ben Greenfield

Boundless Life

5,021 Listeners

The Human Upgrade with Dave Asprey by Dave Asprey

The Human Upgrade with Dave Asprey

7,189 Listeners

The Rich Roll Podcast by Rich Roll

The Rich Roll Podcast

11,762 Listeners

High Intensity Health with Mike Mutzel, MS by Author Mike Mutzel interviews Jeff Bland, Datis Kharrazian, Ben Greenfield, Abel James, Dave Asprey, Ben Lynch, Jade Teta and Corey chuler

High Intensity Health with Mike Mutzel, MS

1,224 Listeners

The mindbodygreen Podcast by mindbodygreen

The mindbodygreen Podcast

2,075 Listeners

The Ready State Podcast by With Kelly and Juliet Starrett

The Ready State Podcast

499 Listeners

The Proof with Simon Hill by Live better for longer

The Proof with Simon Hill

2,602 Listeners

The Genius Life by Max Lugavere

The Genius Life

4,813 Listeners

Dhru Purohit Show by Dhru Purohit

Dhru Purohit Show

3,520 Listeners

The Dr. Hyman Show by Dr. Mark Hyman

The Dr. Hyman Show

9,353 Listeners

The Peter Attia Drive by Peter Attia, MD

The Peter Attia Drive

7,928 Listeners

Huberman Lab by Scicomm Media

Huberman Lab

28,304 Listeners

The Aliquot Preview by Rhonda Patrick, Ph.D.

The Aliquot Preview

45 Listeners

Longevity by Design by Gil Blander PhD

Longevity by Design

181 Listeners

The Matt Walker Podcast by Dr. Matt Walker

The Matt Walker Podcast

902 Listeners

The Dr. Gabrielle Lyon Show by Dr. Gabrielle Lyon

The Dr. Gabrielle Lyon Show

1,126 Listeners