This episode dives into the brutal, mind-altering experience of spending 60 days alone in Antarctica, and how extreme suffering became a catalyst for spiritual awakening, peak performance, and deep inner peace. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

 Host Dave Asprey sits down with elite adventurer, Marine Corps veteran, and Fearvana founder Akshay Nanavati, who dragged a 420lb sled solo across Antarctica in a brutal test of endurance, fasting, and spiritual transformation. Akshay shares how he used suffering as a tool to transmute PTSD, expand consciousness, and awaken what he calls the “paradox of oneness”—where discomfort unlocks the deepest joy. 

Together, they explore how cold therapy, isolation, and extreme hardship reshape dopamine, mitochondria, neurochemistry, and the stories we tell ourselves. Akshay’s journey through darkness retreats, trauma healing, and polar expeditions opens a raw and unfiltered look at self-quantification, mental resilience, and human performance at the edge. 

This episode will challenge your assumptions about comfort, suffering, and what it means to live fully awake. Whether you’re optimizing for longevity, exploring consciousness, or breaking free from invisible scripts, this conversation blends science, spirituality, and hardcore biohacking with moments of unexpected humor and wisdom. 

You’ll Learn: 

• How intentional pain resets your dopamine response and boosts performance 

• Why Akshay chose fasting and cold exposure over nootropics and psychedelics 

• How darkness retreats and solitude sharpen consciousness and intuition 

• The neuroscience behind pain, trauma, and transformation 

• Why true freedom lies in facing discomfort—not avoiding it 

• How to find God in suffering and create meaning from chaos 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

SPONSORS: 

- Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 

- IGNITON | Go to https://www.igniton.com/ 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Akshay’s Website –  https://fearvana.com/ 

• Akshay’s Instagram: https://www.instagram.com/fearvana/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 – Trailer 

• 00:58 – Intro 

• 01:55 – Meeting His Wife Through Intuition 

• 06:28 – Pain, Dopamine & Neurohacking 

• 15:19 – The Paradox of Oneness 

• 21:20 – Darkness Retreats & Mysticism 

• 34:39 – Constructing Reality 

• 38:32 – Consciousness & Perception 

• 39:18 – Polar Travel: Mental & Physical Strain 

• 40:22 – Calculated Risk vs. Suffering 

• 43:40 – Trauma as Fuel 

• 56:26 – Solitude & Self-Reflection 

• 01:05:45 – Embracing Fear & Building Courage 

• 01:09:29 – Death, Meaning & Bliss 

• 01:12:53 – Final Reflections on Purpose 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode reveals how one simple breath pattern can rewire your nervous system, regulate stress in seconds, and become your most powerful tool for human performance and longevity. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Aaron Alexander, a world-renowned human performance coach, manual therapist, and creator of The Align Method. Aaron has worked with elite athletes, high-level entrepreneurs, and celebrity performers to transform the way they move, breathe, and live in their bodies. He merges structural alignment, functional medicine, emotional awareness, and deep nervous system science to help people get unstuck, physically and emotionally. 

Together, they explore the science and strategy behind breathwork, vagal tone, posture, and fascia, revealing how the body stores trauma, how breath shifts brain states, and how physical misalignment can sabotage mental clarity, energy, and even mitochondrial function. They also dive into why mouth taping, tongue posture, nitric oxide, and movement patterns are foundational to sleep optimization, cold therapy adaptation, and long-term vitality. 

You’ll learn how to regulate your state in 10 seconds or less, how to shift from sympathetic overdrive to parasympathetic calm, and how to use tools like humming, OMing, and deep exhales to control your biology in real time. This is a tactical, science-rich, emotionally grounded guide to neurohacking from the inside out. 

If you care about biohacking, functional medicine, sleep optimization, or want to feel stronger, calmer, and more in control—this episode is essential. 

You’ll also hear how Aaron: 

• Uses breath patterns to hack the nervous system and improve strength, mood, and cognition 

• Teaches mouth taping and facial alignment for deeper sleep and recovery 

• Connects trauma, honesty, and physical tension through a somatic lens 

• Guides clients through cold therapy, touch, and movement to recalibrate resilience 

• Applies fascia science and polyvagal theory to elite performance and everyday health 

This is essential listening for anyone exploring Smarter Not Harder protocols, high-level biohacking, and the connection between movement, mitochondria, and mind control. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.  

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. 

SPONSORS: 

- Sunlighten | Go to https://www.sunlighten.com/dave/ and enter code DAVE at checkout to save up to $1,400. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Aaron’s Website –  www.alignpodcast.com 

• Aaron's Instagram: https://www.instagram.com/aaronalexander/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 01:39 Intro: Walking, lifestyle design, and longevity 

• 05:38 Breathwork to shift state and boost energy 

• 21:16 Honesty, alignment, and nervous system health 

• 29:35 Safety, regulation, and somatic awareness 

• 30:43 Touch as therapy and connection 

• 31:53 Pheromones and subconscious signaling 

• 35:00 Breath as a tool for emotional control 

• 39:33 Growth through relationships and repair 

• 43:03 Nature’s role in healing and performance 

• 47:25 Tongue posture, eye movement, and fascia 

• 56:32 Final thoughts on presence and physical truth 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode reveals the ancient health protocols Western medicine forgot, and how they are now being used to heal stress, rewire the nervous system, and radically improve human performance. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Mona Sharma, a renowned Ayurvedic practitioner, celebrity wellness expert, and functional medicine advocate who grew up in a Canadian ashram. Mona combines ancient Vedic practices with cutting-edge science to help her clients, including Will Smith and other high-profile figures, achieve high performance, emotional resilience, and deep-rooted healing. She translates the 5,000-year-old system of Ayurveda into practical strategies anyone can use to optimize health in today’s chaotic world. 

Together, they explore how Ayurvedic biohacking techniques like breathwork, circadian alignment, detoxification, and herbal medicine are now being validated by data in neuroscience, mitochondrial biology, and functional medicine. They also dive into trauma, stress rewiring, nervous system resilience, and how to build your own modern “ashram” for healing and longevity. 

You’ll learn how to shift from hypervigilance into calm, how to optimize vagal tone, and how ancient practices like tongue scraping and ghee detox intersect with modern tools like cold therapy, nootropics, sleep optimization, and self-quantification. 

If you care about biohacking, neurohacking, longevity, or want to understand how emotional states shape mitochondrial function, this episode is packed with grounded insight and powerful takeaways. It offers a masterclass in approaching health through both spiritual and systems biology perspectives, while avoiding burnout and noise. 

You’ll also hear how Mona: 

• Reversed her own heart condition after failed surgeries and medication 

• Guides high-stress clients using Ayurvedic principles and modern lab testing 

• Connects vagal nerve stimulation, breathwork, and emotional detox for lasting nervous system regulation 

• Uses personalized nutrition, pulse reading, and lifestyle upgrades to treat the root cause 

• Brings ancient healing into modern wellness spaces like Upgrade Labs 

This is essential listening for anyone exploring Smarter Not Harder protocols, blending functional medicine with high-level biohacking, and finding sustainable ways to enhance vitality without relying on pharmaceuticals or performance fads. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. 

SPONSORS: 

-Calroy | Head to https://calroy.com/dave for an exclusive discount.  

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Mona’s Website –  https://www.monasharma.com/ 

• Mona’s Instagram: https://www.instagram.com/monasharma/?hl=en 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 00:54 Intro 

• 01:44 Mona’s Personal Healing Journey 

• 03:42 What Ayurveda Really Is 

• 07:15 Breathwork and Daily Rituals 

• 09:41 Where Western Medicine Falls Short 

• 13:27 Ancient Tools That Still Work 

• 22:02 Nervous System as the Healing Key 

• 31:50 Rewiring Through Visualization 

• 32:59 Transformations with Celebrity Clients 

• 33:31 Stress in the Public Eye 

• 34:18 Finding Core Values and Alignment 

• 35:48 Home Detox, Real Impact 

• 37:52 Blending Body and Spirit 

• 48:52 Understanding Your Dosha 

• 54:02 Applying Ayurveda Today 

• 58:34 Final Thoughts and Takeaways 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You’re being programmed, and it’s more subtle and pervasive than you think. From invisible influence to psychological manipulation, this episode shows you how to recognize when your thoughts aren’t really yours. 

Host Dave Asprey uncovers the hidden science of mind control with Harvard historian Rebecca Lemov. She is a professor of the History of Science at Harvard University and one of the world’s leading experts on psychological manipulation, surveillance science, government experimentation, and Cold War brainwashing programs. Her groundbreaking research into MK Ultra, behavioral psychology, and reeducation campaigns reveals exactly how external forces hijack your thoughts, emotions, and decisions, without you knowing. 

They break down how mind control evolved from CIA-funded brain implants and LSD experiments into today’s algorithmic persuasion, trauma-based manipulation, and tech-driven influence. This episode gives you practical tools to defend your thoughts, upgrade your awareness, and reclaim your mental sovereignty. 

This is essential listening for anyone serious about biohacking, mindfulness, longevity, mental performance, self-awareness, hacking the nervous system, emotional control, and high-performance mindset training. 

You’ll Learn: 

• How the CIA used MK Ultra, psychedelics, hypnosis, and implants to test behavior control 

• What mind control looks like in modern media, social platforms, and persuasive technology 

• How unresolved trauma and emotional blind spots leave you vulnerable to manipulation 

• The connection between neurohacking, mindset, and mental autonomy 

• How to recognize when you are running someone else’s code 

• The best psychological tools to build resilience and conscious awareness 

• How to build a “mental firewall” with meditation, breathwork, and attention training 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

SPONSORS: 

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 

-OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Rebecca’s New Book – The Instability of Truth: https://wwnorton.com/books/9781324075264 

• Rebecca's Website: https://rebeccalemov.com/

• Rebecca’s Instagram: https://www.instagram.com/rebeccalemov/?hl=en 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 01:01 Intro 

• 01:49 Mind Control at Harvard 

• 02:54 Hypnosis and Mental Programming 

• 04:48 Morning Routines and Meditation 

• 06:02 AI Companions and Digital Influence 

• 11:17 MK Ultra and Government Experiments 

• 20:25 Archives and the War on Truth 

• 24:49 Marketing and Manipulation 

• 27:22 Chilling CIA Mind Control Stories 

• 33:59 Meditation and God Encounters 

• 34:40 Biohacking Origins 

• 35:15 Building Mental Resilience 

• 36:11 Compassion as Control 

• 37:54 Escaping Modern Programming 

• 39:57 Free Will vs. Influence 

• 46:03 Therapy and Suggestion 

• 49:25 SEER Training and Torture Simulation 

• 01:03:27 One-Pointed Focus 

• 01:06:46 Final Reflections 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your brain runs slow when it’s running on the wrong fuel. 

In this episode of The Human Upgrade, Dave Asprey sits down with Geoffrey Woo, Stanford-trained computer scientist and founder of Ketone-IQ, to reveal the high-performance brain fuel once reserved for Special Forces and elite athletes. 

Discover how ketones helped operators in combat zones sharpen focus, recover faster, and boost reaction speed by up to 30%. Learn why glucose falls short, how to hack your mitochondria for better cognition, and what it takes to unlock rapid-fire thinking on demand. 

This is brain energy for people who want to win, at life, work, and everything in between. Whether you’re fasting, flying, or facing real pressure, ketones flip the switch. 

You’ll Learn: 

• Why ketones beat glucose for focus, speed, and mental clarity 

• How Special Forces use ketones to recover brain function under stress 

• The truth about esters, salts, and the new wave of ketone diols 

• How ketones support faster thinking, emotional control, and clean energy 

• What makes Ketone-IQ different, and how Dave stacks it for peak performance 

• The best ways to combine ketones with fasting, workouts, and meditation 

• Why your metabolism controls your mood, reaction time, and resilience 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Ketone-IQ Website –  https://ketone.com/pages/dave-asprey?utm_source=partners&utm_medium=referral&utm_campaign=DAVE 

• Geoffrey's Website: https://www.geoffreywoo.com/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 – Trailer 

• 02:00 – Intro 

• 02:12 – Ketosis & brain performance 

• 02:53 – Geoffrey’s background 

• 03:52 – Ketone supplement evolution 

• 04:41 – What makes Ketone-IQ different 

• 07:18 – Manufacturing breakthroughs 

• 13:53 – Entrepreneur mindset 

• 18:58 – Future of biohacking 

• 45:59 – Why classics still matter 

• 46:23 – Cultural decline 

• 47:04 – Decentralization 

• 48:25 – Info overload & mental clarity 

• 49:38 – Ketones & consciousness 

• 57:49 – Religion & belief systems 

• 01:03:32 – Key biohacking biomarkers 

• 01:12:47 – Brain data & future upgrades 

• 01:26:34 – Listener offer 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your cells are starving. Not for food—but for oxygen. 

In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Jason Sonners, world-renowned hyperbaric expert and regenerative medicine pioneer, to reveal how controlled oxygen under pressure is becoming one of the most powerful tools in anti-aging and performance science. 

You’ll learn how hyperbaric oxygen therapy (HBOT) triggers stem cell activation, rewires your epigenome, boosts mitochondrial energy, and reverses biological aging—if you use it the right way. Jason shares breakthrough findings from his latest PhD research comparing low- and high-pressure chambers, with surprising results on inflammation, telomeres, cognitive performance, and recovery speed. 

This is next-gen longevity—measurable, stackable, and customizable. From sleep upgrades and HRV boosts to stacking HBOT with fasting, methylene blue, or red light, this episode dives into what it takes to oxygenate your biology at the deepest level. 

You’ll Learn: 

• How hyperbaric oxygen therapy (HBOT) triggers stem cell regeneration and cellular repair 

• Why mild-pressure chambers may be more powerful than you think

• What HBOT does to inflammation, brain fog, and biological aging markers 

• How to stack HBOT with fasting, red light, and methylene blue for amplified results 

• What Dr. Sonners’ PhD research reveals about oxygen pressure and genetic expression 

• The truth about oxygen toxicity—and how to avoid the common mistakes 

• How elite performers use HBOT for brain optimization, recovery, and resilience 

** Get 30% of yourr tickets to the Biohacking conference by going to https://biohackingconference.com/2025 and use code ‘OXYHEALTH’ ** 

Thank you to our sponsors!  

-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.  

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Jason's Website –  www.hbotusa.com 

• OxyHealth Website: https://www.oxyhealth.com/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

 Timestamps: 

• 00:00 Trailer 

• 01:59 Intro 

• 03:14 New research on aging and oxygen 

• 05:39 Mild vs. hard-shell chambers 

• 13:05 HBOT for longevity and stem cells 

• 16:43 How to optimize your sessions 

• 22:35 Best therapies to stack with HBOT 

• 25:40 Oxygen delivery and safety 

• 26:43 Altitude and chamber effects 

• 30:01 Key benefits of hyperbaric therapy 

• 34:22 Supplement synergy and timing 

• 37:25 Pressure and oxygenation findings 

• 39:27 Medical vs. welding oxygen 

• 44:57 Safety myths and toxicity risks 

• 47:39 Future of biohacking with oxygen 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your brain has a gear you’ve never touched. Psychedelics can shift you into it. 

In this episode of The Human Upgrade, Dave Asprey uncovers how high-performance psychedelic mushrooms help you access flow states, rewire your brain, and enhance clarity, energy, and emotional resilience. This is next-level biohacking rooted in real science. 

You will learn how to use psychedelics with intention. When to microdose. When to go deep. How to stack them with nootropics for even stronger results. Dave breaks down the latest research on psilocybin, brain plasticity, trauma release, and how to turn ancient compounds into modern performance tools. 

What You Will Learn in This Episode: 

• How psychedelic shrooms unlock flow, focus, and creative power 

• Why psilocybin boosts neuroplasticity, mood, and emotional healing 

• Microdosing vs. full-dose: what works, when, and how 

• How to stack psychedelics with nootropics and other biohacks 

• The newest research on brain optimization and long-term benefits 

• How to use psychedelics safely, strategically, and for real results 

• Why shrooms may be the strongest mental upgrade in your toolkit 

Thank you to our sponsors!  

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.  

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

 Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Matt’s Website –  https://mattzemon.com/ 

• Matt's Instagram - https://www.instagram.com/matt.zemon/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 – Trailer 

• 01:00 – Intro 

• 06:01 – Personal Psychedelic Journeys 

• 07:39 – Psychedelics and Self-Discovery 

• 11:59 – Safe Use and Smart Navigation 

• 29:09 – Psychedelics and Society 

• 36:40 – Building Trust in the Process 

• 37:14 – Facing Inner Fear 

• 37:38 – Choice and Healing 

• 37:51 – Diet and Conscious Decisions 

• 38:55 – Judgment and Relationships 

• 39:29 – Spirituality and Psychedelics 

• 40:07 – The Entheogenic Reformation 

• 41:29 – Past Lives and Expanded States 

• 43:44 – Where Science Meets Spirituality 

• 49:59 – Gratitude and Compassion in Healing 

• 01:01:47 – The Power of Apologies 

• 01:04:56 – Psychedelics in Therapy 

• 01:08:57 – Final Thoughts on Psychedelics and Culture 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it. 

In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before. 

You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself. 

Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects. 

What You Will Learn in This Episode: 

• Why testosterone matters for men and women at every age 

• The real causes of the global testosterone crash 

• Why diet, sleep, and exercise cannot fully fix low testosterone 

• How testosterone drives dopamine, motivation, and longevity 

• The breakthrough that makes oral testosterone safe and effective 

• How Kyzatrex® lowers SHBG and boosts free testosterone naturally 

• Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan 

• How to safely use testosterone therapy without suppressing fertility or causing side effects 

** Visit livethrive.co/asprey to get a discount on your first month's supply! ** 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Purchase Kyzatrex® – https://livethrive.co/?utm_campaign=11813552-Asprey

• Shalin’s Instagram - https://www.instagram.com/themetabolicceo/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

00:00 Trailer 

00:52 Introduction 

01:29 Global Decline in Testosterone Levels 

02:27 Symptoms of Low Testosterone 

03:48 Personal Journey with Testosterone Therapy 

05:06 The Role of Testosterone in Overall Health 

06:18 Testosterone Levels in Men and Women 

08:48 Challenges and Innovations in Testosterone Delivery 

16:25 The Importance of Circadian Rhythm in Testosterone Therapy 

19:19 The Future of Testosterone Therapy 

32:00 Investment and Development in Testosterone Therapy 

34:57 Introduction to FDA and Hormone Replacement 

35:31 FDA’s Impact on Women’s Health 

36:10 Testosterone and Cardiovascular Risk 

39:05 Testosterone and Depression 

40:30 Testosterone Testing and Misconceptions 

44:58 The Testosterone Project and Female Hormone Therapy 

47:51 Testosterone’s Role in Longevity and Health 

55:37 Cost and Accessibility of Testosterone Therapy 

01:04:03 Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your environment is rewiring your hormones, fertility, and long-term health without your consent. 

In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Aly Cohen, board-certified rheumatologist, integrative medicine specialist, and environmental health educator. Together they expose how common toxins in plastics, pesticides, drinking water, personal care products, and food packaging are hijacking your biology. 

Dr. Cohen explains how daily chemical exposures contribute to autoimmune disease, thyroid dysfunction, hormone imbalance, infertility, obesity, cancer, and accelerated aging. You will learn how to identify hidden endocrine disruptors, spot surprising sources of microplastics and PFAS (“forever chemicals”), and apply science-backed detox strategies to protect your hormones, fertility, metabolism, and longevity. 

What You’ll Learn in This Episode: 

• How chemicals in household, cleaning, and beauty products disrupt hormones 

• The link between environmental toxins, autoimmune disease, thyroid issues, and infertility 

• Hidden sources of microplastics and PFAS chemicals and how to eliminate them 

• Affordable, practical steps to detox your home, water, and personal care routine 

• Dr. Cohen’s top biohacks to protect fertility, balance hormones, and build toxin resilience 

THANK YOU TO OUR SPONSORS! 

-BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.  

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Aly’s Website –  https://thesmarthuman.com/ 

• Aly's Website - https://alycohenmd.com/ 

• Aly’s New Book – Detoxify: https://alycohenmd.com/books 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

00:00 Trailer 

02:01 Introduction 

02:15 Rheumatism and Rheumatology 

03:36 Autoimmune Diseases and Toxins 

04:17 Chemical Impact on Health 

04:49 Personal Health Journey 

06:15 Microplastics and Immune Disruption 

08:21 Resilience and Lifestyle Changes 

21:45 Nutritional Deficiencies 

26:48 Lab Results and Assessments 

34:40 Detoxification and Resilience 

41:14 Personal Journey Continued 

42:22 Clean Drinking Water 

44:20 Travel Hacks for Water 

46:15 Hotel Room Detox Tips 

50:06 EPA Water Standards 

53:06 Restaurant Toxins and Home Safety 

55:36 Top Toxic Household Items 

01:08:31 Synthetic Materials Impact 

01:13:30 Final Thoughts and Book 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could reverse the age of your heart...without leaving home? 

In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems. 

Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You’ll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan. 

What You’ll Learn in This Episode: 

• The link between mitochondrial decline and heart failure 

• Why women’s cardiac risk skyrockets after menopause 

• How Urolithin A stimulates mitophagy and energy renewal 

• New human clinical data on reversing cardiac aging markers 

• Biohacking strategies to fortify your cardiovascular health 

• How to optimize endurance, recovery, and heart resilience 

 THANK YOU TO OUR SPONSORS! 

-STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order.  

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Timeline Website –  https://www.timeline.com/partners/dave-asprey 

• Timeline Instagram - https://www.instagram.com/timeline_longevity/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 — Trailer 

• 02:11 — Supplements that help 

• 03:05 — Long-term benefits 

• 04:38 — Stacking with lifestyle 

• 22:19 — Heart health connection 

• 29:39 — Mitochondria & brain function 

• 33:04 — Glymphatic system & Alzheimer’s 

• 33:53 — Bed height & brain health 

• 34:18 — Why mitochondria matter 

• 35:43 — Inflammation & dysfunction 

• 38:12 — Transplants & consciousness 

• 39:19 — Meditation’s effects 

• 40:33 — The ultimate biohacking stack 

• 43:06 — Creatine for sleep & focus 

• 50:00 — Fertility insights 

• 57:23 — Skin health 

• 01:00:28 — Final thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.