Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it. 

In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before. 

You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself. 

Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects. 

What You Will Learn in This Episode: 

• Why testosterone matters for men and women at every age 

• The real causes of the global testosterone crash 

• Why diet, sleep, and exercise cannot fully fix low testosterone 

• How testosterone drives dopamine, motivation, and longevity 

• The breakthrough that makes oral testosterone safe and effective 

• How Kyzatrex® lowers SHBG and boosts free testosterone naturally 

• Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan 

• How to safely use testosterone therapy without suppressing fertility or causing side effects 

** Visit livethrive.co/asprey to get a discount on your first month's supply! ** 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Purchase Kyzatrex® – https://livethrive.co/?utm_campaign=11813552-Asprey

• Shalin’s Instagram - https://www.instagram.com/themetabolicceo/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

00:00 Trailer 

00:52 Introduction 

01:29 Global Decline in Testosterone Levels 

02:27 Symptoms of Low Testosterone 

03:48 Personal Journey with Testosterone Therapy 

05:06 The Role of Testosterone in Overall Health 

06:18 Testosterone Levels in Men and Women 

08:48 Challenges and Innovations in Testosterone Delivery 

16:25 The Importance of Circadian Rhythm in Testosterone Therapy 

19:19 The Future of Testosterone Therapy 

32:00 Investment and Development in Testosterone Therapy 

34:57 Introduction to FDA and Hormone Replacement 

35:31 FDA’s Impact on Women’s Health 

36:10 Testosterone and Cardiovascular Risk 

39:05 Testosterone and Depression 

40:30 Testosterone Testing and Misconceptions 

44:58 The Testosterone Project and Female Hormone Therapy 

47:51 Testosterone’s Role in Longevity and Health 

55:37 Cost and Accessibility of Testosterone Therapy 

01:04:03 Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your environment is rewiring your hormones, fertility, and long-term health without your consent. 

In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Aly Cohen, board-certified rheumatologist, integrative medicine specialist, and environmental health educator. Together they expose how common toxins in plastics, pesticides, drinking water, personal care products, and food packaging are hijacking your biology. 

Dr. Cohen explains how daily chemical exposures contribute to autoimmune disease, thyroid dysfunction, hormone imbalance, infertility, obesity, cancer, and accelerated aging. You will learn how to identify hidden endocrine disruptors, spot surprising sources of microplastics and PFAS (“forever chemicals”), and apply science-backed detox strategies to protect your hormones, fertility, metabolism, and longevity. 

What You’ll Learn in This Episode: 

• How chemicals in household, cleaning, and beauty products disrupt hormones 

• The link between environmental toxins, autoimmune disease, thyroid issues, and infertility 

• Hidden sources of microplastics and PFAS chemicals and how to eliminate them 

• Affordable, practical steps to detox your home, water, and personal care routine 

• Dr. Cohen’s top biohacks to protect fertility, balance hormones, and build toxin resilience 

THANK YOU TO OUR SPONSORS! 

-BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.  

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Aly’s Website –  https://thesmarthuman.com/ 

• Aly's Website - https://alycohenmd.com/ 

• Aly’s New Book – Detoxify: https://alycohenmd.com/books 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

00:00 Trailer 

02:01 Introduction 

02:15 Rheumatism and Rheumatology 

03:36 Autoimmune Diseases and Toxins 

04:17 Chemical Impact on Health 

04:49 Personal Health Journey 

06:15 Microplastics and Immune Disruption 

08:21 Resilience and Lifestyle Changes 

21:45 Nutritional Deficiencies 

26:48 Lab Results and Assessments 

34:40 Detoxification and Resilience 

41:14 Personal Journey Continued 

42:22 Clean Drinking Water 

44:20 Travel Hacks for Water 

46:15 Hotel Room Detox Tips 

50:06 EPA Water Standards 

53:06 Restaurant Toxins and Home Safety 

55:36 Top Toxic Household Items 

01:08:31 Synthetic Materials Impact 

01:13:30 Final Thoughts and Book 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could reverse the age of your heart...without leaving home? 

In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems. 

Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You’ll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan. 

What You’ll Learn in This Episode: 

• The link between mitochondrial decline and heart failure 

• Why women’s cardiac risk skyrockets after menopause 

• How Urolithin A stimulates mitophagy and energy renewal 

• New human clinical data on reversing cardiac aging markers 

• Biohacking strategies to fortify your cardiovascular health 

• How to optimize endurance, recovery, and heart resilience 

 THANK YOU TO OUR SPONSORS! 

-STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order.  

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Timeline Website –  https://www.timeline.com/partners/dave-asprey 

• Timeline Instagram - https://www.instagram.com/timeline_longevity/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 — Trailer 

• 02:11 — Supplements that help 

• 03:05 — Long-term benefits 

• 04:38 — Stacking with lifestyle 

• 22:19 — Heart health connection 

• 29:39 — Mitochondria & brain function 

• 33:04 — Glymphatic system & Alzheimer’s 

• 33:53 — Bed height & brain health 

• 34:18 — Why mitochondria matter 

• 35:43 — Inflammation & dysfunction 

• 38:12 — Transplants & consciousness 

• 39:19 — Meditation’s effects 

• 40:33 — The ultimate biohacking stack 

• 43:06 — Creatine for sleep & focus 

• 50:00 — Fertility insights 

• 57:23 — Skin health 

• 01:00:28 — Final thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if a laser could help a child speak for the first time—or reverse an “incurable” brain condition? 

In this episode of The Human Upgrade, Dave Asprey talks with Dr. Brandon Crawford, a leading neurotherapist and founder of 528 Innovations, about the emerging science of laser therapy for the brain and body. You’ll learn how light—when precisely pulsed and targeted—can rewire brainwaves, heal trauma, and even influence states of consciousness. 

Dr. Crawford explains how specific laser frequencies are being used to modulate brain states, activate the vagus nerve, improve mood, restore gut-brain communication, and support recovery from conditions like autism and ALS. From EEG shifts to structured water and mitochondrial signaling, this conversation dives deep into biohacking’s most advanced light-based tech. 

What You’ll Learn in This Episode: 

• How laser therapy rewires brainwaves for mood, focus, and clarity 

• The exact brain regions linked to embodiment, intuition, and flow 

• Why pulsing patterns matter more than power in laser tech 

• How light influences trauma recovery and vagus nerve activation 

• The role of structured water and infrared light in cellular repair 

• How patients with ALS and autism responded to 528 protocols 

** Get 30% off GA Virtual Tickets for the Biohacking Conference this May with code ‘528i30’ at checkout! ** 

THANK YOU TO OUR SPONSORS! 

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  

-LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• 528 Innovations Website and used code ‘UPGRADE10’ at checkout –  https://528innovations.com/dave 

• 528 Innovations Instagram - https://www.instagram.com/528innovations/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 – Trailer 

• 02:00 – Intro 

• 02:26 – New breakthroughs in laser therapy 

• 03:07 – Why laser tech needed reinvention 

• 04:21 – How laser light influences the brain 

• 08:03 – Holograms, light, and reality 

• 09:02 – Telepathy and autism connections 

• 12:03 – Rewiring the brain with light 

• 20:01 – Quantum signaling between cells 

• 22:33 – Biohacking and yogic practices 

• 22:54 – Testosterone and natural living 

• 23:37 – Boosting testosterone with lasers 

• 25:21 – Mitochondria and higher awareness 

• 27:35 – Laser benefits across the body 

• 30:29 – Advanced brain stimulation tech 

• 36:19 – ALS recovery and healing cases 

• 40:48 – Closing thoughts and next steps 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if mitochondria weren’t just energy engines — but conscious beings guiding your survival and evolution? 

In this episode, Dave Asprey sits down with Zach Bush, MD, to uncover a radical new science of cellular intelligence. Together, they reveal how your mitochondria, microbiome, and genetic memory do far more than support survival—they actively shape consciousness, drive healing, and accelerate human evolution. 

You’ll discover why chronic disease, fatigue, brain fog, and emotional trauma often trace back to lost cellular communication—and how restoring that network can unlock radical resilience, deeper energy, and true longevity. 

Through the lens of soil health, vibrational biology, light frequencies, and ancient microbial wisdom, Zach Bush shows why the future of biohacking demands reconnection to the deeper intelligence already alive inside you. 

What You’ll Learn in This Episode: 

• How mitochondria act as conscious messengers—not just energy factories—and why that changes everything about health and aging 

• Why rebuilding gut microbiome intelligence strengthens immune function, brain health, and emotional resilience 

• How disrupted cellular communication fuels chronic inflammation, autoimmune disease, and premature aging 

• How emotional trauma imprints onto genetic expression and triggers mitochondrial collapse 

• Why viruses and bacteria serve as evolutionary partners—not enemies—and how they upgrade your biology 

• How “cellular safety” activates healing, regeneration, and peak human performance 

• How carbon cycles, soil health, and light frequencies repair DNA and extend human lifespan 

• Simple daily practices that rebuild cellular coherence, boost energy, and reconnect you to your innate intelligence 

This conversation will rewire how you think about health, disease, and human potential—giving you the tools to upgrade your biology at the deepest level. 

**Check out Zach's exclusive offer for The Human Upgrade listeners at https://intelligenceofnature.com/ and use code ‘DAVE10” for a discount!** 

SPONSORS 

- ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.  

- Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Zach’s Website –  https://zachbushmd.com/ 

• Zach’s Instagram - https://www.instagram.com/zachbushmd/?hl=en 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 00:52 Intro: Microbiome and Human Connection 

• 03:07 Microbiome’s Role in Nutrition and Health 

• 05:48 Chemical Farming’s Impact on Soil and Health 

• 09:23 Mitochondria and Cellular Communication 

• 26:00 Viruses, Exosomes, and Evolution 

• 34:36 The Observer Effect and Reality 

• 40:08 Tech vs. Nature in Healing 

• 41:04 Light, Mitochondria, and Cellular Energy 

• 42:01 Choosing Tech or Natural Regeneration 

• 43:44 The Miracle of Life and Human Potential 

• 45:05 Healing Generational Trauma 

• 47:38 Shamanic States and Connection 

• 01:05:48 Sacred Geometry and Group Healing 

• 01:12:48 Rational vs. Mystical Perspectives 

• 01:14:52 Finding Common Ground 

• 01:15:10 Inside the Supplement Room 

• 01:15:47 Emerging Tech in Biohacking 

• 01:15:58 Non-Tech Health Upgrades 

• 01:16:11 Stem Cell Concerns and Cautions 

• 01:17:31 Nature Deficit and Health Impacts 

• 01:19:09 Curiosity and Personal Growth 

• 01:20:56 Generational Shifts and Gender 

• 01:24:20 Strengthening Relationships Through Differences 

• 01:28:31 Storytelling’s Power Over Data 

• 01:38:24 Longevity and Embracing Elderhood 

• 01:44:47 Final Thoughts and Future Visions 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You’ve probably heard of HIIT—but have you heard of “REHIT?”  This isn’t just another workout trend...it’s a new science-backed way to train with maximum efficiency and zero wasted time. If you’re still jogging, you’re wasting hours for minimal results. 

In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol that’s obliterating fitness myths. 

Forget the treadmill grind. REHIT (Reduced Exertion High-Intensity Training) exercising delivers: 

• 12% VO₂ max increase

• 6x the fitness gains of daily jogging 

• 62% drop in diabetes risk 

• 5x more BDNF for brain power 

—all with just 8 minutes of effort per week. 

But was it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows how a brand-new way of exercising is giving explosive results—no matter your age or fitness level. 

What You’ll Learn in This Episode: 

• Why Zone 2 cardio is outdated advice for most people 

• The science of REHIT and how 2 sprints beat 2-hour workouts 

• The shocking data on VO₂ max, insulin sensitivity, and lifespan 

• How CAROL uses AI to personalize exercise for any age or ability 

• Why most people fail at fitness—and how to fix it 

• The real role of lactate, BDNF, and HRV in recovery and resilience 

• How perimenopausal women benefit more from REHIT than HIIT or jogging 

• Why adherence—not intensity—is the #1 predictor of results 

• What to do when you’re traveling or don’t have access to the tech 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• CAROL Bike Website and use code ‘DAVE’ for a discount –  https://carolbike.com/ 

• CAROL Bike Instagram - https://www.instagram.com/thecarolbike/?hl=en 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 Introduction to REHIT Training 

• 00:24 Meet Ulrich Dempfle: The Mind Behind CAROL Bike 

• 00:51 The Science and Benefits of REHIT 

• 01:44 Comparing Traditional Cardio to REHIT 

• 02:32 Dave Asprey’s Personal Fitness Journey 

• 03:43 The Efficiency of REHIT Training 

• 05:03 Practical Applications and Accessibility of REHIT 

• 08:22 Addressing Common Concerns and Misconceptions 

• 11:25 The Future of Fitness: REHIT and Beyond 

• 18:29 Scientific Validation and Real-World Results 

• 31:53 Clinical Trials and Tech Integration 

• 32:06 Upgrade Labs and CAROL Bike 

• 33:00 Mitochondrial Effectiveness and Insulin Sensitivity 

• 36:05 Zone Two Training vs. High-Intensity Training 

• 42:02 REHIT for Perimenopausal Women 

• 48:18 AI and Personalized Exercise 

• 57:52 Lactate and Exercise Benefits 

• 01:01:48 Interval Walking Training 

• 01:04:01 Conclusion and Future Insights 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your bloodwork looks normal. Your doctor says you’re fine. But you still feel exhausted, inflamed, anxious—or worse. 

In this episode, Dave Asprey talks with Dr. Daniel Pompa, a leading voice in cellular detox and root-cause healing, to expose the hidden stressors hijacking your energy, hormones, and metabolism—even when your labs say you’re healthy. 

Dr. Pompa shares his personal health collapse and reveals how cellular dysfunction, neurotoxicity, and hormone resistance drive the chronic fatigue epidemic. If you’ve ever felt dismissed by “perfect” bloodwork, this conversation will rewire how you think about sickness—and show you how to reclaim real, lasting wellness. 

What You’ll Learn in This Episode: 

• Why your bloodwork can be “perfect” while your cells are on fire 

• The overlooked hormone resistances sabotaging your energy and metabolism 

• The 3-legged stool of chronic illness—and what actually drives disease 

• What “upstream detox” really means, and why most cleanses make you worse 

• Why toxins trigger genetic expression (and how to shut that down) 

• How to fix unexplainable fatigue, anxiety, and weight gain from the inside out 

• Why true healing starts with fixing the cell, not the symptom 

It’s time to stop chasing symptoms—and start upgrading from the root. 

**Check out Dr. Pompas EXCLUSIVE protocol built for The Human Upgrade listeners at davetestkit.com and use code ‘10OFF’ for a discount!** 

SPONSORS 

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.  

-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Dr. Pompa’s Website –  https://drpompa.com/ 

• Dr. Pompa’s Instagram - https://www.instagram.com/drpompa/?hl=en 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 00:55 Intro 

• 01:10 Healthy Is the New Sick 

• 02:27 Bloodwork & Hormone Resistance 

• 04:32 Dr. Pompa’s Health Collapse 

• 08:38 Toxins & Environmental Triggers 

• 15:01 Why Most Detox Fails 

• 29:16 The 5 Rs of Cellular Healing 

• 37:06 Olive Oil: Cure or Concern? 

• 38:11 Fat Balance for Energy 

• 42:13 Cholesterol & Saturated Fat 

• 46:26 Restoring Cellular Energy 

• 51:08 The Power of Diet Variation 

• 56:57 Plant Toxins Explained 

• 01:03:28 Emotional & Spiritual Detox 

• 01:13:55 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people run from stress. The world’s highest performers run toward it. 

Sébastien Page manages over $500 billion in global assets. He’s the CIO of one of the world’s largest investment firms, and he wrote The Psychology of Leadership while living under relentless pressure. His secret? He doesn’t avoid stress—he uses it as a tool for performance, clarity, and control. 

But here’s the twist: this isn’t just about boardrooms or billion-dollar trades. 

Whether you’re running a company, chasing a deadline, or just trying to stop procrastinating on your goals—this conversation will flip what you think you know about pressure, performance, and productivity. 

You’ll learn why trying to “relax your way to success” doesn’t work—and how to harness discomfort to create better decisions, higher output, and more resilience in every part of life. 

What You’ll Learn in This Episode: 

• The psychology of stress and why zero stress leads to burnout 

• How procrastination can boost creative performance 

• What astronauts, athletes, and leaders have in common 

• Why the key to better decisions is strategic patience, not speed 

• The stress-performance curve no one taught you in school 

• Why losing is the real path to mastery (and what Roger Federer can teach you) 

• The difference between being nice vs. being kind—and why it matters 

It's time to start turning stress into strategy. 

SPONSORS 

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.  

-BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. 

 Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Sébastien’s New Book –The Psychology of Leadership –  https://www.psychologyofleadership.net/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 Intro 

• 02:00 Book Launch & Setup 

• 02:45 Buy or Sell? Market Insights 

• 03:20 Stress and Performance 

• 04:28 Sports Psychology Breakdown 

• 09:48 Federer & the Power of Losing 

• 26:42 Rethinking Feedback 

• 31:32 Stress as a Tool 

• 44:10 Listening as Leadership 

• 44:17 Traits of Great Leaders 

• 44:54 Psychology for Entrepreneurs 

• 45:37 Leading Beyond Work 

• 46:09 Sleep Tracking Anxiety 

• 47:39 Channeling Stress 

• 49:04 Extreme Pressure Moments 

• 50:42 The Corporate Athlete 

• 59:08 Vulnerability & Leadership 

• 01:05:23 Goal-Induced Blindness 

• 01:12:34 Finding Meaning at Work 

• 01:18:08 Leadership at Home 

• 01:20:27 Final Takeaways 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you. 

But what if there was a way to take it back… and hack the system? 

In this mind-expanding episode, Dave sits down with two elite hacker-founders—Michael Tiffany, CEO of Fulcra.ai, and Vishakh, founder of Monadic DNA—to explore a radical shift in the way we store, protect, and use our most personal data. 

Together, they break down the Web3 tech stack powering this revolution. Enter Nillion, a distributed, privacy-preserving compute network that allows you to share and analyze your encrypted data… without ever giving it away. 

From genomic privacy to AI sovereignty, this episode exposes the hidden architecture of control—and how to escape it. You’ll learn how cutting-edge blockchain and cryptography are rewriting the rules of ownership, consent, and even identity itself. 

What You’ll Learn in This Episode: 

• Why your DNA is already in government databases—and how long they keep it 

• How Nillion enables secure computation on private data 

• What it means to build a “cybernetic operating system” for your body 

• Why Fulcra.ai is building the orchestration layer of human optimization 

• How Monadic DNA helps you profit from your genetics—without giving them away 

• Why owning your data is the next frontier of biohacking 

• The surprising connection between decentralization, health freedom, and consciousness 

• How to join the movement toward true data sovereignty 

If you’ve ever felt like you’re giving away too much to big tech, big pharma, or just the internet itself—this conversation will change how you see your data… and your body. 

**Join the Fulca sleep study today! Visit https://fulcra.ai/sleep to sign up** 

**Get a 30% discount on Fulca with code “DAVE”!  

SPONSORS 

-IGNITON | Go to https://www.biohackingconference.com/ and get your tickets while there are still great discounts available. Learn more at https://igniton.com/.  

-Calroy | Head to https://calroy.com/dave for an exclusive discount. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Fulcra Dynamics Website –  https://www.fulcradynamics.com/ 

• MonadicDNA Website: https://monadicdna.com/ 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 – Trailer 

• 02:01 – Intro 

• 02:26 – Data Privacy & AI: The Big Shift 

• 03:21 – Meet Michael Tiffany 

• 04:41 – Cybernetic Operating Systems 

• 05:13 – Wearables & Personal Augmentation 

• 08:21 – Meet Vishakh: DNA Privacy Mission 

• 09:25 – Why Genetic Data Needs Protection 

• 11:30 – New Tech: Encryption & Privacy Tools 

• 16:13 – How Multi-Party Compute Works 

• 41:58 – Emergence: Behavior & Systems 

• 49:11 – Meditation & Mental Reprogramming 

• 50:20 – Distributed Computing & Biology 

• 56:15 – Environment Shapes Potential 

• 57:57 – Empowering Individuals at Scale 

• 01:00:31 – Biohacking Meets Inner Awareness 

• 01:04:01 – The Dark Side of DIY Mind Hacks 

• 01:06:09 – Future of Biohacking & Community

• 01:12:28 – Integrating Genetic & Life Data 

• 01:20:39 – Why We Started Biohacking 

• 01:25:01 – Favorite Current Biohacks 

• 01:31:41 – Final Thoughts & Resources 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours? 

In this mind-altering episode of The Human Upgrade, Dr. Steven Gundry reveals a startling new theory: your gut microbiome might be controlling your thoughts. From addiction and depression to obesity and inflammation, the microbes living in your gut—bacteria, fungi, viruses, even parasites—may be pulling the strings on your brain chemistry, mood, and behavior. 

Dave Asprey and Dr. Gundry dive deep into The Gut-Brain Paradox, exposing how the gut-brain axis operates more like a microbial command center than a digestive system. You’ll learn why probiotic pills rarely work, how the wrong microbes can drive compulsive behavior, and how toxic foods, glyphosate, and antibiotics have turned our guts into neurological war zones. 

Most shocking of all? Microbes may not just influence addiction—they may cause it. 

What You’ll Learn in This Episode: 

• How your gut microbiome can hijack your brain and influence your thoughts and behavior 

• Why certain microbes may actually cause addiction, obesity, and depression 

• How antibiotics, glyphosate, and processed foods are turning your gut into a desert 

• How to rebuild your gut ecosystem using postbiotics, fermented foods, and precision inputs 

• Why food cravings might be microbial mind control—and what to do about it 

• What the latest science reveals about the gut-brain axis, neurotransmitters, and neuroinflammation 

Sponsors: 

-Sunlighten | Go to https://www.sunlighten.com/dave/ and enter code DAVE at checkout to save up to $1,400.  

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Dr. Gundry’s Instagram –  https://www.instagram.com/drstevengundry/?hl=en 

• Dr. Gundry’s Website: https://drgundry.com/ 

• Dr. Gundry’s New Book The Gut-Brain Paradox: https://www.barnesandnoble.com/w/the-gut-brain-paradox-steven-r-gundry-md/1146019686?ean=9780062911803 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 — Trailer 

• 02:01 — Intro 

• 03:55 — The Gut-Brain Connection 

• 04:45 — Microbiome Communication and Control 

• 08:19 — The Role of Fungi and Plants 

• 11:29 — Microbiome Diversity and Health 

• 19:05 — Addictive Microbiome and Behavior 

• 28:17 — Antibiotics and Gut Health 

• 30:49 — Listener Concerns and Gut Health 

• 31:02 — Whale Watching and Climate Change 

• 32:58 — Understanding SIBO and Bacterial Migration 

• 34:02 — The Role of Soluble Fiber and Fermented Foods 

• 36:12 — Complexity of Gut Microbiome 

• 36:49 — Restoring Ecosystems and Gut Health 

• 38:23 — Precision Microbiome Manipulation 

• 41:31 — Calcium Formation and Gut Bacteria 

• 43:56 — Oxalates vs. Lectins Debate 

• 46:04 — Whole Foods and Glyphosate Concerns 

• 51:47 — Dopamine Levels and Gut Health 

• 54:59 — Conclusion and Book Promotion 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.