Could a single molecule be the difference between vibrant longevity and early decline? 

Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD. 

This master molecule fuels your mitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could stop the decline and even reverse it? 

Dr. Salzman breaks down the game-changing science behind NAD, CD38, and cellular repair—and the fastest, most effective ways to optimize your levels for peak performance, health, and longevity. 

Get ready to rethink everything you thought you knew about aging, pharmaceuticals vs. supplements, and the radical new approach to living better, longer. 

What You’ll Learn: 

• The #1 reason your NAD is disappearing—and how to fix it 

• Why NAD is the missing link in energy, DNA repair, and disease prevention 

• The hidden enzyme (CD38) that’s sabotaging your longevity 

• How to supercharge mitochondria, optimize blood flow, and fight aging at the source 

• Why the supplement industry has it wrong—and the best way to boost NAD naturally 

• The shocking truth about the FDA, pharmaceuticals, and the future of anti-aging medicine 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Wonderfeel Instagram –  https://www.instagram.com/getwonderfeel/  

•  Wonderfeel Supplement :  https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast • 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

00:00 Trailer 

01:07 Introduction and Episode Overview 

02:29 Meet Dr. Andrew Salzman 

02:36 From Physician to Researcher 

03:39 Pharmaceuticals vs. Nutritionals 

04:17 The Role of NAD in Longevity 

06:32 Challenges in Longevity Research 

12:58 Understanding NAD and PARP 

14:34 NAD’s Impact on Health 

23:19 Gut Health and Longevity 

27:43 Innovations in NAD Supplementation 

41:27 Customer Feedback and Product Effectiveness 

42:41 Surprising Benefits of NAD for Sexual Health 

44:47 NAD and Vascular Health 

48:46 NAD’s Role in Aging and Longevity 

54:03 NAD and Lifestyle Choices 

01:03:02 NAD and Cognitive Function 

01:06:18 NAD and Exercise 

01:13:42 NAD and Sleep 

01:21:54 Final Thoughts on NAD and Longevity 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to the metabolism masterclass!

Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast. 

From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it’s not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity. 

What You’ll Learn: 

• The #1 driver of insulin resistance—and why most doctors miss it 

• Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction 

• How fasting, cold therapy, and red light impact your metabolism 

• The truth about carbs, seed oils, and why some people can’t gain fat 

• How to tell if insulin resistance is wrecking your energy & health 

 Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

•  Benjamin’s new book How Not To Get Sick :  https://a.co/d/aADlMWv 

• Benjamin’s YouTube Page –  https://www.youtube.com/@benbikman 

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

-Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. 

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

Timestamps: 

00:00 Trailer 

00:52 Introduction to Dr. Benjamin Bikman 

02:20 The Battle Against Conventional Dietetics 

04:12 Understanding Insulin Resistance 

06:29 The Two Paths to Insulin Resistance 

10:19 Fasting and Metabolic Health 

14:11 Insulin and Cognitive Enhancement 

18:16 Identifying Insulin Resistance 

30:12 The Role of Insulin in Fat Storage 

42:04 Understanding Glucose and Insulin Dynamics 

42:26 The Role of Exercise in Glucose Regulation 

42:54 AMPK and Muscle Contraction 

45:21 Calories In, Calories Out Debate 

46:15 The Myth of Calorie Counting 

50:13 Ketosis and Metabolic Rate 

51:14 Intermittent Fasting and Muscle Preservation 

55:21 Insulin Resistance and Ketogenic Diets 

01:02:04 Circadian Rhythm and Insulin Sensitivity 

01:08:08 Environmental Toxins and Insulin Resistance 

01:13:03 The Impact of Seed Oils on Insulin Resistance 

01:19:22 Final Thoughts and Resources 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people wait for inspiration. But what if you could train your brain to create on demand? 

Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius? 

In this must-listen episode, Rick sits down with Dave to explore the science and soul of creativity, revealing how meditation, mindfulness, biohacking, and unconventional thinking fuel artistic breakthroughs. From rewiring your brain with meditation to stacking biohacks for peak creative flow, Rick shares the techniques that have kept him at the top of the music industry for over 40 years. 

Dave and Rick go deep on the mental and physiological hacks that enhance creative performance, the surprising link between biohacking and artistry, and the rituals that keep Rick sharp, focused, and endlessly inspired. 

What You’ll Learn: 

• How Rick Rubin taps into creative flow—and how you can too 

• The surprising connection between meditation and peak artistic performance 

• Why biohacking isn’t just for longevity—it’s for creative mastery 

• Rick’s favorite tools for mental clarity, focus, and creative breakthroughs 

• The real secret behind working with the world’s biggest artists 

• How to cultivate an environment that fuels creativity 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Rick’s New Book The Creative Act: A way of Being: https://a.co/d/2bLbjeS   

• Rick’s Instagram: https://www.instagram.com/rickrubin/?hl=en 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off.  

BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. 

Timestamps: 

• 00:00 – Trailer 

• 00:51 – Intro to Rick Rubin 

• 02:51 – Rick’s Musical Journey 

• 03:06 – The Creative Process 

• 08:31 – Biohacking & Sensitivity 

• 13:46 – Meditation & Creativity 

• 19:37 – Rick’s Weight Loss Story 

• 29:21 – Eating Habits & Rhythm 

• 29:55 – Advanced Biohacking 

• 31:23 – Oxygen Therapy & Carbogen 

• 35:16 – Peptides & Longevity 

• 45:59 – Prayer, Gratitude & Performance 

• 51:03 – Reflections on Life & Mortality 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle? 

Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths about financial freedom, why fear is your biggest enemy, and how to break free from the psychological traps that keep you stuck. 

Tony and Dave dive deep into the wealth-building playbook that the world’s top investors use (including Warren Buffett, Ray Dalio, and Paul Tudor Jones), plus the biohacks and routines that fuel Tony’s legendary stamina. From the real secret to compounding wealth to stem cell breakthroughs that could change human longevity, this episode will shift the way you think about money, health, and success. 

Most people dream of financial freedom, but few actually achieve it. What’s holding you back—and how can you break through? 

What You’ll Learn: 

• The biggest mistake people make with money (and how to avoid it) 

• The mindset of the ultra-wealthy—how top investors think differently 

• Why fear is your greatest enemy in investing and personal success 

• The three essential money buckets—security, growth, and dreams 

• Tony’s top biohacks for insane energy and peak performance 

• The real secret to happiness and fulfillment (it’s not what you think) 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Tony’s Website: https://www.tonyrobbins.com/ 

• Tony’s Instagram: https://www.instagram.com/tonyrobbins/?hl=en 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

-Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide.  

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Timestamps: 

• 00:00 Intro 

• 00:50 Meet Tony Robbins 

• 02:18 Financial Wisdom & Motivation 

• 05:43 Psychology of Wealth 

• 10:10 Investment Strategies 

• 15:24 Balancing Money & Experiences 

• 21:21 Power of Giving 

• 30:06 Paying for College 

• 31:00 Commitment & Success 

• 31:53 Energy & Biohacks 

• 35:12 Cryotherapy & Inflammation 

• 38:54 Stem Cells & Regeneration 

• 41:59 Financial Freedom 

• 46:35 Wnt Pathway Breakthroughs 

• 52:35 Health & Longevity 

• 56:34 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back? 

In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke free from opioid addiction, lost 130 pounds, and rewired his mindset for long-term success. He and Dave dive into the power of discipline, the dangers of quick fixes, and the hard truths about personal transformation. 

Timbaland opens up about the mental shift that saved his life, how he kicked a high-dose opioid habit cold turkey, and why his new “drug” of choice is something anyone can access. 

Most people want change, but few actually achieve it. What separates those who succeed from those who stay stuck? And how can you apply Timbaland’s hard-earned lessons to your own life? 

What You’ll Learn: 

• The #1 mindset shift that made weight loss & addiction recovery possible 

• Why self-discipline beats willpower—and how to build it like a muscle 

• The real reason most diets fail—and what actually works 

• The truth about opioid addiction and recovery—why most people never escape 

• How your daily habits shape your future—and how to change them fast 

• The shocking link between addiction, metabolism & long-term health 

• How Timbaland stayed clean without rehab—and why relapse wasn’t an option 

We’d like to extend our gratitude to Eudēmonia for providing the opportunity to record with Timbaland at their event. Eudēmonia, created by the founders of Wanderlust Festival, is a premier health and well-being summit. You can learn more about their initiatives and upcoming events here: https://wanderlust.com/ 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Timbaland’s Website: https://www.timbaland.com/ 

• Timbaland’s Instagram : https://www.instagram.com/timbaland/?hl=en 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

-STEMREGEN | | Head to https://www.stemregen.co/dave for 20% off your first order.  

-Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. 

Timestamps: 

• 00:00 Trailer 

• 00:00 Introduction to the Human Upgrade 

• 00:09 Timbaland on Passion and Energy 

• 00:42 Balancing Passion and Avoiding Burnout 

• 02:04 Dreams and Manifestations 

• 04:51 Overcoming Addiction 

• 05:59 The Role of God in Recovery 

• 09:28 Helping Others with Addiction 

• 14:00 Weight Loss and Health Transformation 

• 16:29 Trusting Your Body’s Signals 

• 18:45 Skepticism About Modern Products 

• 21:10 Exploring Longevity and Individual Health 

• 22:23 The Intersection of Music and Spirituality 

• 25:56 Understanding Synesthesia and Its Impact 

• 27:41 The Journey to Weight Loss and Fitness 

• 35:08 The Importance of Sleep and Health 

• 37:23 Final Thoughts and Reflections 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Could the right form of a single vitamin be the difference between thriving and barely surviving? 

In this Part 2 conversation, human biologist and longevity expert Gary Brecka reveals the #1 overlooked factor that’s wrecking your health: methylation—your body’s ability to convert nutrients into fuel. If this process fails, your hormones, energy, and even mental health take a nosedive. 

Gary and Dave dive deep into the real cause of anxiety, ADHD, and mood disorders, the hidden genetic reason why diets fail, and why Big Pharma isn’t talking about this critical health breakthrough. 

Are you unknowingly setting yourself up for disease? What’s the simple fix that can reverse anxiety, gut problems, and even prevent genetic disease? And why is your doctor ignoring one of the biggest markers of longevity? 

What You’ll Learn: 

• The MTHFR gene mutation—and why it’s quietly affecting millions 

• Anxiety, ADHD, and depression—why these disorders start in your cells, not your brain 

• The gut-brain connection—how your microbiome controls your mood 

• Why your “healthy diet” might be hurting you (and what to eat instead) 

• How nutrient deficiencies are passed from mother to child—and how to stop it 

• The truth about homocysteine—the blood marker that could predict your lifespan 

• Why most people are living at 50% capacity—and how to get your energy back 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Gary Brecka’s Website: https://bit.ly/4hlfyti 

• Gary Brecka’s YouTube: https://bit.ly/3E3Aaba 

• Gary Brecka’s Instagram: https://bit.ly/3PNsgFe 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

• The Mold Movie!: https://moldymovie.com/ 

SPONSORS:  

-BON CHARGE | Go to https://boncharge.com/ and use coupon code DAVE to save 15%.  

-Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions. 

Timestamps: 

• 00:00 Trailer 

• 00:31 What Is Methylation? 

• 01:37 MTHFR, Folate & Your Health 

• 04:17 How Methylation Affects Disease 

• 06:41 Nutrient Deficiencies & Health Risks 

• 07:09 Why Blood Work Matters 

• 11:44 Homocysteine & Heart Health 

• 21:37 Catecholamines & Anxiety 

• 34:28 The Link Between Nutrients & Mood 

• 34:48 How Catecholamine Ratios Affect Mental Health 

• 35:39 Personal Health Struggles & Lessons 

• 36:25 The Role of Methylation in Wellness 

• 37:57 Methylation & Relationship Dynamics 

• 39:49 Hidden Dangers of Mold Toxicity 

• 52:55 Hydrogen Water for Health 

• 01:01:19 Mitochondria’s Role in Longevity 

• 01:02:23 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Why were our grandparents stronger, healthier, and living longer—without the “advancements” of modern medicine? 

Gary Brecka, one of the world’s leading experts in human longevity and performance, exposes the hidden crisis that’s wrecking your hormones, slashing your energy, and cutting your lifespan short. In this no-holds-barred conversation with Dave Asprey, they break down the corporate greed, medical corruption, and environmental toxins designed to keep you sick, weak, and dependent. 

What’s really causing the testosterone collapse in men and women? How is AI changing the game for hormone optimization, biohacking, and personalized health? And why are we aging faster than ever—while Big Pharma profits? 

This first episode in a two-part series is a deep dive into hormone optimization, testosterone, cholesterol myths, longevity hacks, and the AI-driven future of health.  

What You’ll Learn: 

• Why testosterone levels are plummeting—and how to restore them naturally 

• The real reason life expectancy is dropping (hint: it’s not just diet) 

• The Kellogg conspiracy—how food was designed to lower libido & testosterone 

• Why mainstream medicine is failing you (and what to do instead) 

• How AI and big data are rewriting the rules of health & longevity in

• The shocking truth about cholesterol, heart disease, and pharmaceuticals 

• Why functional medicine & biohacking hold the key to real health optimization 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Gary Brecka’s Website: https://bit.ly/4hlfyti 

• Gary Brecka’s YouTube: https://bit.ly/3E3Aaba 

• Gary Brecka’s Instagram: https://bit.ly/3PNsgFe 

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  

Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%. 

Timestamps: 

• 00:00 – Trailer 

• 00:42 – Introduction to The Human Upgrade 

• 01:35 – Meet Gary Brecka 

• 03:32 – Performance vs. Longevity 

• 06:16 – The Importance of Testosterone 

• 15:11 – Historical Hormone Levels 

• 18:00 – Population Averages in Health 

• 18:51 – The Flaws of Grading on a Curve 

• 20:35 – Corporate Influence on Health 

• 21:04 – The Danger of Cumulative Dosage 

• 22:20 – Social Media & Public Perception 

• 25:19 – Independent Research Matters 

• 32:21 – Big Data & AI in Health 

• 36:02 – The Future of Personalized Medicine 

• 36:49 – Conclusion & Teaser for Part Two 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Billy Carson, a Harvard-certified expert in ancient civilizations and an MIT-trained scholar in neuroscience, has spent decades decoding the mysteries of lost technology, quantum reality, and human optimization. Alongside Elisabeth Carson, a biohacker and neuroscience researcher, they bridge the gap between ancient wisdom and modern science—revealing secrets that could transform your mind, body, and reality. What if the Great Pyramid wasn’t just a monument but a powerful energy device designed to amplify human potential? What if ancient civilizations understood frequency, grounding, and longevity in ways modern science is only beginning to grasp? 

In this episode, the Carsons connect the dots between lost technology, bioenergetics, and conscious relationships, showing how these ancient systems align with the latest research on vibrational healing, mitochondrial energy, and peak performance. They explore how quantum fields influence cellular regeneration, why high-frequency living affects health and relationships, and how suppressed knowledge could redefine the future of wellness. 

What You’ll Learn: 

• How the Great Pyramid functioned as an energy generator—and how to apply its principles to longevity 

• The forgotten science of frequency and its effects on health, aging, and vitality 

• How quantum energy and grounding can optimize mitochondrial function 

• The connection between biohacking, consciousness, and relationships 

• Why suppressed ancient knowledge holds the key to true human potential 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

•  4biddenknowledge YouTube – https://www.youtube.com/@ForbiddenKnowledge1 

•  4biddenknowledge Website – https://www.4biddenknowledge.com/ 

•  Billy Carson Instagram – https://www.instagram.com/4biddenknowledge/?hl=en 

•  Elisabeth Carson Instagram - https://www.instagram.com/elisabethicarson/?hl=en 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

• Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 

• ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

Timestamps: 

• 00:00 Trailer 

• 00:39 Meet Dave Asprey 

• 02:16 Trauma, Success & Relationships 

• 04:22 Billy & Elizabeth Carson on Growth 

• 10:09 Birth & Pre-Natal Trauma 

• 19:30 Healing & Biohacking 

• 23:16 Relationships & Triggers 

• 28:35 Vitamin D & Nutrients 

• 35:25 Empathy & Intuition 

• 37:24 Manifestation 

• 41:25 Neuroscience & Altered States 

• 53:04 Ancient Wisdom & Biohacking 

• 57:45 Ancient Technologies 

• 01:08:26 Giants & Six Fingers 

• 01:08:58 Sumerian Artifacts 

• 01:10:28 Hidden Agendas 

• 01:13:32 Hypnosis Revelations 

• 01:19:21 Power of Intuition 

• 01:30:11 Love & Self-Discovery 

• 01:35:52 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Everything you’ve been told about weight loss is a lie!

In this episode, Dr. Nick Norwitz, a metabolic health expert with accolades from Oxford and Harvard, joins Dave to expose the biggest myth in dieting: Calorie Counting. Together, they dismantle outdated weight-loss advice and reveal the truth about metabolism that could revolutionize your health. 

Dr. Norwitz shares cutting-edge science and personal stories that challenge the “eat less, move more” narrative, uncovering why traditional dieting often fails—and what actually works. From the role of ketosis in healing chronic illness to the surprising ways fasting affects hair loss, metabolism, and inflammation, this episode is packed with actionable insights that you won’t hear anywhere else. 

You’ll also learn how viruses might be fueling food addiction, why gut health is the missing key to metabolic recovery, and how new research could unlock the future of personalized medicine. If you’ve ever felt like your metabolism was holding you back, this conversation will give you the tools to take control of your health for good. 

What You’ll Learn: 

• Why calorie counting is useless—and the better way to lose weight 

• The shocking truth about how your metabolism ACTUALLY works 

• How ketosis and fasting can heal inflammation and chronic disease 

• The role of gut health and microbiome diversity in weight loss 

• New research on food addiction and its surprising link to viruses 

• Why individualization is the key to sustainable health 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Nick Norwitz’s YouTube – https://www.youtube.com/@nicknorwitzPhD 

• Nick Norwitz’s Website – https://www.nicknorwitz.com/ 

• Follow Nick on Instagram – https://www.instagram.com/nicknorwitz/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

• Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 

• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Timestamps: 

• 00:00 Trailer 

• 00:39 Meet Dr. Nick 

• 04:44 Nick’s Health Journey 

• 07:54 Keto Diets 

• 09:37 Modern Medicine Challenges 

• 13:31 Exercise vs. Diet 

• 14:32 Obesity Memory 

• 17:36 Keto Cycling 

• 20:51 Microbiome Health 

• 26:26 Fasting & Hair Loss 

• 34:56 Alzheimer’s Insights 

• 45:11 Cold Plunge Benefits 

• 45:43 Dopamine Boosts 

• 46:26 Cold Plunge & Inflammation 

• 47:15 Best Time to Cold Plunge 

• 48:18 Pain & Dopamine 

• 49:31 Exercise & Stress 

• 51:49 Cholesterol & Inflammation 

• 01:05:42 Debunking Calories In/Out 

• 01:07:09 Food Addiction 

• 01:11:15 Metabolic Health Tips 

• 01:24:13 Nick’s Mission 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the key to living longer isn’t avoiding stress—but mastering it 

Jeff Krasno, founder of Commune and renowned stress expert, joins Dave to reveal why most of us have stress all wrong. In this fascinating conversation, Jeff redefines how we think about stress—showing how it can be your greatest ally instead of your worst enemy. From his groundbreaking new book Good Stress to the ancient practices that have stood the test of time, Jeff shares how to unlock the hidden potential of stress to build resilience, foster connections, and boost longevity. 

You’ll discover why crying is an emotional biohack, how to spot the fine line between good and bad stress, and why the modern world keeps us stuck in a chronic stress loop—and how to break free. Jeff also dives into the science of emotional regulation, the role of connection in health, and the radical power of embracing discomfort to create balance and ease in your life. 

What You’ll Learn: 

• How to turn stress into a tool for resilience and longevity 

• Why Jeff calls chronic ease the root of modern disease 

• The science of tears: how crying regulates stress and boosts health 

• How you can build a “psychological immune system” for emotional regulation 

• The key to balancing good stress and avoiding burnout 

• Why discomfort is the path to growth—and how to embrace it 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Jeff Krasno’s Website – https://www.jeffkrasno.com/ 

• Preorder Good Stress – https://www.onecommune.com/goodstressbook#preorder 

• Follow Jeff on Instagram – https://www.instagram.com/jeffkrasno 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

• Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. 

• Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. 

Timestamps: 

• 00:00 – Intro 

• 01:02 – Meet Jeff Krasno 

• 02:16 – Topanga Fires Survival 

• 04:14 – Good Stress vs. Bad Stress 

• 06:14 – Cortisol’s Role in Stress 

• 13:13 – Social Media Triggers 

• 20:32 – Stressful Conversations 

• 31:34 – Cold Therapy Benefits 

• 42:26 – Stress and Recovery Balance 

• 45:58 – High Altitude Training 

• 47:29 – Cold Therapy Fails 

• 49:42 – Science of Crying 

• 54:51 – Reflections on Legacy 

• 59:37 – Balancing Stress and Ease 

• 01:10:30 – Nature and Spirituality 

• 01:22:52 – Facing Death with Grace 

• 01:32:53 – Closing Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.