In "Episode 7" of the series on "Present and future of diagnostics in prostate cancer", Dr. Marcin Miszczyk (PL) and Prof. Wolfgang Fendler (DE) discuss the role of PSMA-PET imaging in modern prostate cancer management.

They examine how this advanced imaging modality compares to conventional techniques, and whether its improved sensitivity and specificity are enough to shift treatment paradigms. Drawing on key trials like proPSMA, ORIOLE, STORM, and RADIOSA, the episode highlights both the clinical value and the unresolved questions surrounding PSMA-PET, particularly regarding overdiagnosis, stage migration, and missed lesions.

Dr. Miszczyk and Prof. Fendler consider its potential in dose escalation, personalised therapy, and integration with MRI for better staging. They also reflect on upcoming changes in clinical guidelines, especially for high-risk patients, and share a hopeful outlook on the impact of PSMA-PET in shaping more precise and effective prostate cancer care.

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