Guest: Dr. Robert Wolfe

Dr. Wolfe’s went to college at UC Berkeley, where he was a 3-sport varsity athlete, playing basketball, track, and golf. After college, Dr. Wolfe went back to school for his PhD which led to a career in clinical research. The focus of Dr. Wolfe’s research is on the regulation of muscle metabolism, particularly as affected by aging and stressors such as injury, sepsis and cancer. His research has been performed largely in human patients and normal volunteers. Dr. Wolfe has developed models using stable isotopes to quantify a variety of metabolic processes in human subjects including the oxidation and production of fatty acids, various aspects of carbohydrate metabolism, and the rates of muscle protein synthesis, breakdown, and the transport of amino acids between blood and muscle tissue. Dr. Wolfe served as a faculty member at Harvard Medical School for nine years, and is currently the Director of the Center for Translational Research in Aging and Longevity at the Reynolds Institute on Aging in Little Rock, Arkansas. He has published over 500 peer-reviewed research articles, three books, and holds many active patents. Dr. Wolfe is a co-founder of The Amino Company, which was formed to bring his patented amino acid formulas, developed over 40 years of clinical research, to the public.

Summary

Dr. Robert Wolf discusses the importance of protein and amino acids in the diet, the differences between animal and plant protein, and the recommended daily protein intake. He also explains the benefits of amino acid supplementation for specific conditions and the importance of balanced amino acid formulations. Dr. Wolf emphasizes the role of amino acids in liver health and detoxification, particularly the benefits of histidine. Overall, amino acids play a crucial role in maintaining optimal health and function. In this conversation, Bob Wolfe discusses the role of amino acids in liver health, specifically in the context of fatty liver disease. He explains that fatty liver disease is not solely caused by alcoholism, but is also common in individuals with obesity. Wolfe's research has shown that reducing methionine and increasing other amino acids can effectively reduce liver fat. Additionally, he mentions the potential anti-inflammatory effects of amino acids and the importance of routine dosing and timing for optimal results.

Takeaways

Protein is essential for optimal health and function, and amino acids are the building blocks of protein.

Animal protein is generally more easily digested and absorbed than plant protein, but plant-based proteins can be combined to meet nutritional requirements.

A high protein intake, above the recommended daily amount, can have numerous health benefits and is well within dietary guidelines.

Amino acid supplementation can provide additional benefits beyond what can be achieved with dietary protein alone.

Amino acids play a crucial role in liver health and detoxification, and histidine is particularly important in reducing liver fat and inflammation.

Chapters

00:00 Introduction and Background

07:48 The Importance of Protein in the Diet

15:11 Animal Protein vs. Plant Protein

16:23 Recommended Daily Protein Intake

21:27 Protein Intake for Specific Conditions

27:41 The Difference Between Branched-Chain Amino Acids and Essential Amino Acids

36:33 The Importance of Balanced Amino Acid Formulations

43:07 Amino Acid Supplementation for Aging

50:36 The Role of Amino Acids in Liver Health and Detoxification

55:36 The Benefits of Histidine in Liver Health and Detoxification

58:13 Fatty Liver Disease: Alcoholic vs. Non-Alcoholic

01:02:48 The Role of Aminos in Liver Health

01:07:17 Aminos and Kidney Support

01:09:41 Anti-Inflammatory Effects of Aminos

01:11:55 Dosing and Timing of Aminos

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Matt Coffman / Integrative Thoughts

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