Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, UK, interviews Professor Delzenne, President of the Louvain Drug Research Institute, at the UCLouvain, Brussels, Belgium. The podcast is focused on "Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients" published in paper copy in Gut in November 2020, and online at: https://gut.bmj.com/content/69/11/1975