In this week’s View, Dr. Eagle discusses the comparative risks of initial aortic events associated with genetic thoracic aortic disease, then looks at the harmonization of the American College of Cardiology/American Heart Association’s and the European Society of Cardiology/European Society of Hypertension’s Guidelines on blood pressure and hypertension. Finally, Dr. Eagle examines a study looking at how polygenic risk score may predict sudden death in patients with coronary disease and preserved systolic function.