In this week’s View, guest host Deepak Bhatt, MD, MPH, FACC, reviews articles about the impact of ischemic burden reduction after chronic total occlusion percutaneous coronary intervention (PCI) on long-term prognosis and cardiac symptom relief, the relationship between operator PCI using rotational atherectomy volumes and in-hospital patient outcomes, and the impact of age on the safety and efficacy of ticagrelor monotherapy after PCI.