Dr Stephanie Mathieson (Institute for Musculoskeletal Health, University of Sydney) is sounding the alarm and tackling the super-wicked problem of opioid prescription. She covers the opioid epidemic, why communication within the multidisciplinary team is critical to helping patients manage pain, and how musculoskeletal clinicians can be part of the solution to overuse of medicines. Dr Mathieson's work is nested in the WISER Healthcare collaboration, a leading multidisciplinary research collaboration focused on reducing overdiagnosis and overtreatment in health care.