Dr. Scott Canna is an Associate Professor of Pediatrics (Rheumatology), and Attending Physician, Pediatric Rheumatology and Immune Dysregulation at the Children’s Hospital of Philadelphia. His group studies the mechanisms of immune dysregulation. He talks about auto- and hyperinflammatory diseases and the role of IL-18. He also discusses hemophagocytic lymphohistiocytosis and adapting therapies for children.

Microbial Metabolites in Infectious Diseases – Dietary tryptophan protects against gastrointestinal infection by activating the neurotransmitter receptor dopamine receptor D2.

T Cell Tolerance – Scientists used neural networks and hybrid mice to see how the transcription factor AIRE recognizes gene promoters.

Microbes in Immunotherapy – Lactobacillus johnsonii promotes the production of indole-3-propionic acid, which improves immune checkpoint blockade responsiveness.

Alzheimer’s Disease Microglia – Research suggests a link between genetic risk factors for Alzheimer’s disease and microglial lipid droplet accumulation.

Image courtesy of Dr. Scott Canna

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