Dr. Mitchell Kronenberg is a Professor and President Emeritus at La Jolla Institute for Immunology. His lab studies how innate-like T cells adapt to different tissue environments. He talks about his work on MAIT cells and mucosal immunology, as well as his time leading the Institute.

Immune System Regeneration – Depleting myeloid-biased HSCs in aged mice restores features of a more youthful immune system.

Gasdermin in Pyroptosis – Gasdermin D N-terminal domain palmitoylation controls gasdermin membrane localization and activation.

Antibody-Drug Conjugates for Cancer – Scientists developed an antibody–drug conjugate that could kill TRBC1+ cancer cells in vitro and cure human T cell cancers in mouse models.

Hemorrhagic Fever Cell Receptors – The low density lipoprotein receptor is critical for the Crimean–Congo hemorrhagic fever virus to enter host cells.

Image courtesy of Dr. Mitchell Kronenberg

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