Dr. Caleb Lareau is an Assistant Professor at Memorial Sloan Kettering Cancer Center. His lab aims to understand how cells in our bodies adapt, expand, and evolve during the course of our lives, particularly in the immune system. He talks about cross-training in bioinformatics and immunology, and herpesvirus reactivation in CAR T cells.

Blocking Lung Injury in Influenza – Scientists developed an inhibitor to block necroptosis in severe influenza infections.

Germinal Center Memory B Cells – IL-4 signaling can regulate memory B cell selection.

Intestinal Barrier Defence – Citrobacter rodentium targets a subset of absorptive intestinal epithelial cells in the mid–distal colon, which stimulate T cells to produce sustained IL-22 signals to mitigate further spread of the pathogen.

Fast-Acting Glucocorticoids – The anti-inflammatory properties of glucocorticoids involve reprogramming of the mitochondrial metabolism of macrophages.

Image courtesy of Dr. Caleb Lareau

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