Dr. Marcelo Hill is the Head of the Laboratory of Immunoregulation and Inflammation at the Institut Pasteur de Montevideo. He is also the Founder and Chief Scientific Officer of ARDAN ImmunoPharma. His research focuses on immune regulation in cancer, and how T cells respond to immunotherapy in melanoma. He talks about improving immunotherapy efficacy by activating the inflammasome, and how he is pushing this research towards the clinic by collaborating with industry and creating a spin-off company.

He is then joined by Drs. Marion Brunck and María Julia Lamberti, who discuss the upcoming meeting of the Latin American and Caribbean Association of Immunology, taking place November 4-8 in Buenos Aires. They discuss the challenges and opportunities in the Latin American immunology community, and how this conference aims to promote collaborations and empower early-career researchers.

Staphylococcus aureus Biofilm – Scientists studied tissue microenvironments in models of S. aureus craniotomy and prosthetic joint infections.

T Helper Cell Differentiation – Researchers found that RAMP3 has a cell-intrinsic role in TH1 cell fate determination.

Probiotic Immunotherapy – Researchers used E. coli to deliver neoepitopes that drive T cell-mediated anticancer immunity.

Microglia in Alzheimer’s Pathology – APOE internalization is regulated by cholesterol metabolism in microglia.

Image courtesy of Dr. Marcelo Hill

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