Dr. Luke O’Neill is a Professor and Chair of Biochemistry at Trinity College Dublin, where his research group is focused on exploring the molecular basis of inflammation. His lab endeavors to provide a better understanding of the metabolic regulation of immune cell function and the innate immune system, with the aim of developing novel therapies to treat inflammatory diseases.

A Phage Counter-Defense – An orphan antitoxin counter-defense element has been discovered in phages that can overcome a bacterial toxin-antitoxin phage defense system. (5:40)

Pathogenic Memory T Cells – Researchers uncover a pathogenic subset of CD8+ memory T-cells that promote tissue inflammation. (14:05)

The Role of Macrophages in Graft-Versus-Host Disease – Scientists show that IL-34 reprograms macrophages to mitigate gastrointestinal complications in GVHD. (23:41)

A New Treatment Path for Nerve Damage – Research suggests that macrophages may play a protective role in preventing neuropathy from developing. (30:19)

Image courtesy of Dr. Luke O’Neill

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