Christof Koch and Jim have a wide-ranging conversation about the science of consciousness. They start by exploring some key topics brought up in his book, The Feeling of Life Itself: Why Consciousness Is Widespread But Can't Be Computed: defining conscious experience, the importance of feeling, the historical value of Cartesian dualism, the challenge of materialism to explain mental phenomena, emergent consciousness, neural correlates of consciousness & enabling factors, ways of understanding qualia, and consciousness vs intelligence. They finish this episode by talking about integrated information theory (IIT): origins & dynamics, consciousness substrates & what it could mean for AI, small & large phi, uniting consciousnesses, IIT vs. global workspace theory (GWT) experimentation, panpsychism, and much more.