Find out about a new epilepsy discovery; how the microRNA-335 molecule impacts people with both Dravet Syndrome and Temporal Lobe Epilepsy, and what this could mean for research going forward! All with post-doc researcher Mona Heiland!

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🔗 Website & more about Mona: 👇🏻

https://www.torierobinson.com/epilepsy-sparks-insights/mona-heiland-newly-discovered-molecule-microrna-335

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Chapters 📖

00:00 Trailer & Intro

00:45 Meet Mona

01:07 Explaining Sodium Channel Epilepsies

06:03 Understanding MicroRNAs and Their Role in Epilepsy

07:47 Research Findings on MicroRNA-335 and Sodium Channels

10:01 Future Directions in Precision Therapies for Epilepsy

11:18 Conclusion & thanks

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Don’t understand all the terms used? Check out the Epilepsy Sparks Glossary! 👇🏻 https://www.epilepsysparks.com/glossary 

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Physicist Sjoerd Vos shares his research in neuroimaging; aiming at decreasing language decline caused by temporal lobe resections!

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🔗 Website & more about Sjoerd

https://www.torierobinson.com/epilepsy-sparks-insights/sjoerd-vos-physics-mri-temporal-lobe-epilepsy-resection-cognitive

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Don’t understand all the terms used? Check out the Epilepsy Sparks Glossary! 👇 https://www.epilepsysparks.com/glossary 

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Eduardo Pérez Palma, a neurogenetics scientist and bioinformatician, discusses his work in neurogenetics and epilepsy research, emphasising the importance global collaboration in studying the epilepsies in different parts of the world! Eduardo also shares the upcoming Latin American Congress on Genetic Epilepsiesin Jan 2025; which aims to bring together experts from various fields to share knowledge and perspectives!

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🔗 Website & more about Eduardo: 👇🏻

https://www.torierobinson.com/epilepsy-sparks-insights/eduardo-perez-palma-neurogenetics-dee-latin-america 

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Chapters 📖

- Intro to Eduardo

- The Value of Genetic Testing in Epilepsy

- Diversity and Representation in Genetic Research

- Understanding Developmental Epileptic Encephalopathies (DEEs)

- Contributing to Epilepsy Research

- Latin American Congress on Epileptsy Genetics

- Conclusion & thanks

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Don’t understand all the terms used? Check out the Epilepsy Sparks Glossary! 👇🏻 https://www.epilepsysparks.com/glossary 

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#genetics #neurogenetics #exomesequencing #epilepsy

Learn of exciting research into a drug screening platform for personalised medicine for the epilepsies - through adult neurologist and researcher Patrick Kwan; head of the Kwan Lab! Patrick describes the process of extracting stem cells from blood, culturing them, and using them to develop new treatments for drug-resistant epilepsy. The conversation highlights the importance of collaboration and data sharing in epilepsy research.

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🔗 Website & more about Patrick👇

https://www.torierobinson.com/epilepsy-sparks-insights/patrick-kwan-advances-stem-cell-research-epilepsy

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Don’t understand all the terms used? Check out the Epilepsy Sparks Glossary! 👇 https://www.epilepsysparks.com/glossary 

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People with an epilepsy might be nervous about getting "gene therapy" - but in today's mini-episode, in part 2 of 2, epileptologist José M Serratosa is asked if he would get gene therapy and why(!), explains the use of viral vectors for treating genetic epilepsies, where we are in preclinical development, what is next, and what is also holding us back!

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🔗 Transcription & more about José: 👇🏻

https://www.torierobinson.com/epilepsy-sparks-insights/jose-m-serratosa-gene-therapies-viral-vectors 

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Don’t understand all the terms used? Check out the Epilepsy Sparks Glossary! 👇🏻 https://www.epilepsysparks.com/glossary 

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#epilepsy #genetherapy #genetics #vectors #viralvectors #lafora 

What does the future for epilepsy treatments hold?! Epileptologist José M Serratosa shares his predictions for epilepsy gene therapies; highlighting the importance of addressing all symptoms - including cognitive, motor, and psychiatric - as well as the seizures. Jose explains the role of viral vectors and how they may save people! This is part 1 of 2 with José - in part 2, the conversation goes into the challenges of research clinical trials for these therapies; from basic, to pre-clinical, to clinical!

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🔗 Transcription & more about José: 👇🏻

https://www.torierobinson.com/epilepsy-sparks-insights/jose-m-serratosa-future-epilepsy-gene-therapies 

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Don’t understand all the terms used? Check out the Epilepsy Sparks Glossary! 👇🏻 https://www.epilepsysparks.com/glossary 

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#epilepsy #genetherapy #genetics #vectors #viralvectors #lafora 

Michael Sperling, a prof of neurology and director of the Jefferson Comprehensive Epilepsy Center, educates us on laser ablation therapy for epilepsy! He and Torie discuss the minimally invasive nature of the procedure, its advantages over traditional open surgery, and its efficacy in reducing seizures. They also touch on the suitability of the therapy for different age groups and types of epilepsy. The conversation highlights the precision and safety of laser ablation therapy and its potential to improve outcomes for patients.

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Michael’s related papers 📜

https://www.researchgate.net/profile/Michael-Sperling-2  

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Who knows about Acute Symptomatic Seizures and how the babies and children experiencing them can be carefully weaned off of the anti-seizure medications they are on? Paediatric neurologist and epilepsy specialist Maria Gogou from University General Hospital of Alexandroupolis, Greece, explains more. Paediatric neurologist and epilepsy specialist Maria Gogou from University General Hospital of Alexandroupolis, Greece, explains more. 

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🔗 Website & more about Maria 👇

https://www.torierobinson.com/epilepsy-sparks-insights/maria-gogou-acute-symptomatic-seizures-weaning-babies-asms 

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Don’t understand all the terms used? Check out the Epilepsy Sparks Glossary! 👇 https://www.epilepsysparks.com/glossary 

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Children may benefit from being weaned off of anti-seizure medications when they are on the ketogenic diet. Plus, find out how the ketogenic diet can significantly benefit children with epilepsy - even when it doesn’t control their seizures! Paediatric neurologist Maria Gogou discusses her work in managing rare and complex epilepsies in children.

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🔗 Paper: “Antiseizure medication reduction and withdrawal in children with drug-resistant epilepsy after starting the ketogenic diet” 👇

https://onlinelibrary.wiley.com/doi/full/10.1111/dmcn.15377

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🔗 Website, transcription, & more about Maria 👇

https://www.torierobinson.com/epilepsy-sparks-insights/maria-gogou-staying-on-a-keto-diet-that-doesnt-work-dravet

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Don’t understand all the terms used? Check out the Epilepsy Sparks Glossary! 👇https://www.epilepsysparks.com/glossary 

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David Henshall shares how information gathered when researching worms led to the discovery of microRNA, a far improved understanding of the epilepsies, and potential treatments - all explained in his new book (link below)! This is episode 2 of 2.

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David’s book  📖

https://www.amazon.co.uk/Fine-Tuning-Life-MicroRNAs-Genomes-Regulators/dp/1009466429/ref=sr_1_1

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🔗 Website & more about David: 👇🏻

https://www.torierobinson.com/epilepsy-sparks-insights/david-henshall-micro-rna-epilepsy 

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Don’t understand all the terms used? Check out the Epilepsy Sparks Glossary! 👇🏻

https://www.epilepsysparks.com/glossary 

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