Jim Webb (Colby College) comes on the podcast to talk to Merle and Lee about his work in historical epidemiology and how its multidisciplinary approach could transform how we teach and research diseases. After first defining what historical epidemiology is and why it is a difficult field in which to do research, Jim gives examples of how he approached these questions based on his malaria research in both the recent and deep past. He then turns to how research on diseases works today and how historical epidemiology could help transform research, teaching, and academia as a whole moving forward. At the end, Jim discusses his recent book on intestinal diseases and how his research was different and similar based on environmental, ecological, and social factors that shaped its impact.