The Filtrate:

Matt Sparks

Jennie Lin

Samira Farouk

Joel Topf

Swapnil Hiremath

And two special guests:

Dawn J. Caster, Assistant Professor at University of Louisville

Alfred Kim, Assistant Professor of Medicine at Washington University (Twitter)

Show Notes:

NephJC coverage of the trial: The Bliss trial

In the NEJM: https://www.nejm.org/doi/full/10.1056/NEJMoa2001180

Turtles all the way down: https://en.wikipedia.org/wiki/Turtles_all_the_way_down

Nature previews Nephrology on BAFF: https://www.nature.com/articles/nri844

Phase III trial results with blisibimod, a selective inhibitor of B-cell activating factor, in subjects with systemic lupus erythematosus (SLE): results from a randomised, double-blind, placebo-controlled trial: https://pubmed.ncbi.nlm.nih.gov/29563108/

BRIGHT-SC: Blisibimod Response in IgA Nephropathy Following At-Home Treatment by Subcutaneous Administration: https://clinicaltrials.gov/ct2/show/NCT02062684

Guideline for naming monoclonal drugs: https://www.antibodysociety.org/wordpress/wp-content/uploads/2017/07/INN-2017-Reference-20.pdf

A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group: https://pubmed.ncbi.nlm.nih.gov/9541091/

Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis https://pubmed.ncbi.nlm.nih.gov/25757867/

A Day In The Life Of Dr. Anthony Fauci: https://www.huffpost.com/entry/anthony-fauci-fighting-covid-19_n_5fc7fed7c5b61bea2b14e3ee

MC Arbatin MD FPCP FPSN @mcamd: the glomerulus tree: https://twitter.com/mcamd/status/1337744822543605760

finished product: https://twitter.com/mcamd/status/1338429211963322371

The Filtrate:

Swapnil Hiremath

Samira Farouk

Matt Sparks

Joel Topf

Jennie Lin

And two special guests:

Katherine Tuttle Clinical Professor Division of Nephrology, Medical & Scientific Director, Providence Medical Research Center/Sacred Heart Center, Professor of Basic Medical Sciences, WWAMI Program Washington State Universityendocrinologist and nephrologist at the University of Washington

Ian de Boer Professor in the Division of Nephrology, Adjunct Professor, Epidemiology and Associate Director, Kidney Research Institute

Show Notes:

The Guideline

NephJC’s summary

Accord study showing harm from tight glycemic control

Advance Trial the other trial showing harm from tight glycemic control

2007 KDOQI diabetes guidelines

2012 KDOQI diabetes guidelines

ADA guidelines

Rob Nelson, diabetes legend

Classic pathology of diabetic nephropathy

Should all patients with diabetes have a kidney biopsy?

Flow trial: A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

The Grading of Recommendations Assessment, Development and Evaluation (short GRADE) working group. Don’t you love it when the first word in an acronym is the acronym itself.

Continuous Glucose Monitoring and Use of Alternative Markers To Assess Glycemia in Chronic Kidney Disease

Continuous glucose monitoring and icodextrin.

Keto diets have 1.2 to 1.7 g protein/kg

Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events by the PURE investigators

The Association Between Kidney Disease and Diabetes Remission in Bariatric Surgery Patients With Type 2 Diabetes

Jordy Cohen and Bariatric surgery in CKD at Kidney Week

Metformin knocking out of the park in UKPDS

Kidneys at the Zoo: What Can We Learn from Comparative Renal Physiology? at Kidney Week

The Filtrate:

Swapnil Hiremath

Samira Farouk

Matt Sparks

Joel Topf

Jennie Lin

And two special guests:

Katherine Tuttle Clinical Professor Division of Nephrology, Medical & Scientific Director, Providence Medical Research Center/Sacred Heart Center, Professor of Basic Medical Sciences, WWAMI Program Washington State Universityendocrinologist and nephrologist at the University of Washington

Ian de Boer Professor in the Division of Nephrology, Adjunct Professor, Epidemiology and Associate Director, Kidney Research Institute

Show Notes:

The Guideline

NephJC’s summary

Accord study showing harm from tight glycemic control

Advance Trial the other trial showing harm from tight glycemic control

2007 KDOQI diabetes guidelines

2012 KDOQI diabetes guidelines

ADA guidelines

Rob Nelson, diabetes legend

Classic pathology of diabetic nephropathy

Should all patients with diabetes have a kidney biopsy?

Flow trial: A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

The Grading of Recommendations Assessment, Development and Evaluation (short GRADE) working group. Don’t you love it when the first word in an acronym is the acronym itself.

Continuous Glucose Monitoring and Use of Alternative Markers To Assess Glycemia in Chronic Kidney Disease

Continuous glucose monitoring and icodextrin.

Keto diets have 1.2 to 1.7 g protein/kg

Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events by the PURE investigators

The Association Between Kidney Disease and Diabetes Remission in Bariatric Surgery Patients With Type 2 Diabetes

Jordy Cohen and Bariatric surgery in CKD at Kidney Week

Metformin knocking out of the park in UKPDS

Kidneys at the Zoo: What Can We Learn from Comparative Renal Physiology? at Kidney Week

The Filtrate:

Swapnil Hiremath

Samira Farouk

Matt Sparks

Joel Topf

And two special guests:

Vandana Dua Niyyar, Professor of Medicine at Emory University and the president elect of American Society of Diagnostic and Interventional Nephrology. Wears lead.

Sophia Ambruso, assistant professor and nephrologist at the University of Colorado.

Show Notes:

Drug-Coated Balloons for Dysfunctional Dialysis Arteriovenous Fistulas

The NephJC summary

The article in the NEJM

The Haskal study, Stent Graft versus Balloon Angioplasty for Failing Dialysis-Access Grafts in the NEJM from 2010

Accuracy of physical examination in the detection of arteriovenous fistula stenosis

The Big Three was a trio of Major League Baseball starting pitchers for the Atlanta Braves from 1993-2002 which consisted of Greg Maddux, Tom Glavine, and John Smoltz. The Big Three combined to win seven National League Cy Young Awards in the 1990s and helped lead the Atlanta Braves to a 1995 World Series win. Each member of the Big Three has had their jersey retired by the Atlanta Braves and has been inducted into the Baseball Hall of Fame. (From Wikipedia)

The Trerotola study, Drug Coated Balloon Angioplasty in Failing AV Fistulae

Scathing anti-interventional nephrologist editorial by Trerotola

Rebuttal though data by Beathard, Effectiveness and safety of dialysis vascular access procedures performed by interventional nephrologists

And then a walk back and update by Tretola…What is the current and future status of interventional nephrology?

Paclitaxel mechanism of action video with awesome music

The role of fungus in the paclitaxel story

Twitter comment on the half life of balloon delivered paclitaxel

The meta analysis of peripheral revasculaization having a mortality signal with paclitaxel: Risk of Death Following Application of Paclitaxel-Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

FDA warning about paclitaxel balloons: Treatment of Peripheral Arterial Disease with Paclitaxel-Coated Balloons and Paclitaxel-Eluting Stents Potentially Associated with Increased Mortality

The NephJC primer on non-inferiority trials: Understanding the vortex of non-inferiority trials

ASN Distinguished Clinical Service Award 2020 goes to Vandana Dua Niyyar! (and Derek Fine, who is also a great guy)

ASN Kidney Week Sessions:

Samira: Embracing Technology: Nephrology 2.0

Swapnil: Hard-to-Control Hypertension: What to Do Next?

Vandana: A Look Inside: Noninvasive Imaging of Kidney Diseases