People have been taking psychoactive drugs since the beginning of human history, but there hasn’t been a lot of good scientific study of these substances. One person who has been trying to turn a scientific lens toward them is University of Chicago Professor Harriett de Wit, and what she’s discovered is surprising.

The latest research shows that there may be more uses for drugs like MDMA and LSD than sending people on mind-altering trips. In fact, they could radically change how some people engage with therapy. De Wit also examines microdosing, why it is so popular, and whether it does what people suggest.