We’ve long marveled at how efficiently plants convert sunlight into energy—but no one guessed they were using quantum mechanics to do it.

In this episode, we speak with Greg Engel, a pioneering biophysicist at the UChicago Pritzker School of Molecular Engineering and the Department of Chemistry who helped launch the field of quantum biology. Engel explains how plants and bacteria evolved to exploit quantum effects for photosynthesis—and how understanding these systems could spark a revolution in quantum sensing, medicine, and neuroscience.

Engel’s team has already built quantum sensors inspired by nature’s designs, with the potential to transform how we detect disease, develop drugs, and even read neural signals. The ultimate goal? A new era of quantum medicine, powered by the weird and wonderful physics found in leaves. A new large gift is helping that mission along by establishing The Berggren Center for Quantum Medicine and Biology at The UChicago Pritzker School of Molecular Engineering, partnering with BSD, UC Medicine and others.

You’ve heard of plastic polluting oceans. But what if it’s polluting you—your brain, your reproductive system, even your unborn children?

In this eye-opening episode, we speak with Prof. Matthew Campen, a scientist at the University of New Mexico, whose latest studies have uncovered evidence of microplastics in placentas, reproductive organs and brains of humans—particularly in the frontal cortex, where decision-making and personality live.

We explore how these plastic particles are entering our bodies (hint: it’s not just your water bottle), what they might be doing to us, and why scientists are just beginning to understand the true scope of the issue. From declining sperm counts to potential links with dementia, this episode asks a critical question: Are microplastics the next big public health crisis?

Hello listeners…we're re-releasing one of our favorite Big Brains episodes—an incredibly insightful conversation with psychologist Adam Alter. If you've ever felt stuck in your life or career, this episode offers practical strategies and surprising science to help you move forward.

From why your best ideas might come after you feel like giving up, to what Netflix can teach us about breaking through inertia, this episode is packed with revelations.

We’ll be back with brand-new episodes starting in August—also, check out our new YouTube page where you can now watch video versions of Big Brains.

One of the benefits of producing this podcast at the University of Chicago is that there are often events on campus that bring in not just one Big Brain, but many in order to find answers to the some of the most complex problems of our time. I recently had the pleasure of hosting one such event on artificial intelligence that we want to share with you today. It was part of the Graham School’s Leadership & Society Initiative Symposium, examined how AI could change everything and, more importantly, whether it should.

Artificial intelligence is evolving faster than most of us can keep up with—and its impact is already reshaping our lives, from the hospital to the courtroom to the art studio. Is AI moving too fast? Are we focusing on the wrong questions? And what comes after today’s generation of models? It’s a candid, complex, and eye-opening conversation you won’t want to miss.

For a more than a century, the Food and Drug Administration has worked to protect public health. In his research, Harvard University physician-researcher Jerry Avorn has examined how the FDA’s once-rigorous gold standard approval process has been affected by a powerful shortcut known as the Accelerated Approval Program—originally designed for desperate AIDS and cancer patients. He says that change in the 1990s has allowed more than half of all new drugs onto the market before drug companies have proven they actually help people.

In his new book Rethinking Medications: Truth, Power and the Drugs We Take, Avorn cites numerous examples: from a cold medicine that doesn’t de-congest to billion-dollar cancer treatments that only shrink lab results to the controversial Alzheimer’s drug Aduhelm—approved despite no clear cognitive benefits. In this episode, Avorn explores whether some prescriptions in your medicine cabinet are safe, effective and worth the money.

Prof. James Evans, a University of Chicago sociologist and data scientist, believes we’re training AI to think too much like humans—and it’s holding science back.

In this episode, Evans shares how our current models risk narrowing scientific exploration rather than expanding it, and explains why he’s pushing for AIs that think differently from us—what he calls “cognitive aliens.” Could these “alien minds” help us unlock hidden breakthroughs? And what would it take to build them?

When someone we know or love starts to develop psychological issues, we don't often associate it with a form of dementia. However, this trait is one of the most common signs of frontotemporal dementia (FTD) — the most common neurodegenerative disease in people under the age of 65. In his new book, Mysteries of the Social Brain: Understanding Human Behavior Through Science, Dr. Bruce Miller highlights his experiences observing people with FTD and what they have taught him about what he calls the "social brain."

Dr. Bruce Miller has been observing people with FTD for decades in the Memory and Aging Center at the University of San Francisco, where he is also Professor of Neurology and the Founding Director of the Global Brain Health Institute. He shares key insights on how to keep our "social brain" healthy and how it can even unlock our creative potential.

The search for life beyond Earth is no longer science fiction—it takes a lot of data, powerful telescopes and a bit of cosmic detective work. And at the center of this search is University of Chicago astrophysicist Jacob Bean. Bean was part of the team that made history by detecting carbon dioxide in the atmosphere of a distant planet using the James Webb Space Telescope—a major step forward in our ability to study exoplanets.

Bean uses cutting-edge tools and discoveries that are reshaping how we think about planet habitability, biosignatures and our place in the universe. From potentially habitable exoplanets like K2-18b to false hopes like Gliese 486b, Bean shares why the atmospheres of these faraway worlds might hold the key to one of humanity’s oldest questions: Are we alone in the universe?

Despite decades of policy ideas, pouring millions of dollars into the problem, and a slow pace of gun control measures, the United States hasn’t made much progress on curbing the epidemic of gun violence in our country.

For the past 25 years, Prof. Jens Ludwig of the University of Chicago has examined the questions of: Why does gun violence happen, and is there anything we can do about it?

In his new book, Unforgiving Places: The Unexpected Origins of American Gun Violence, Ludwig—who is director of the University of Chicago Crime Lab—discusses why we've been thinking about the gun violence problem in the wrong ways.

Drawing upon behavioral economics, he explains that most shootings are not premediated; rather, the result of arguments that escalate into violence. Using data-backed interventions, Ludwig introduces new ideas beyond policy and policing to get at the real root causes of gun violence today.

What if a single number, derived from your DNA, could predict your income, education level or even who you're likely to marry? In his new book “The Social Genome,” Princeton University sociologist Dalton Conley explores the science behind how our genes are shaping our society in ways that are both profound and unsettling.

Conley explains how our genes, and the genes of those around us, are influencing our lives in ways we barely understand—from fertility clinics selecting embryos based on genetic traits to the rise of “genetic sorting” in everything from dating to zip codes. He also debunks the idea of nature versus nurture, revealing how deeply intertwined they truly are.

Are we heading toward a future of genetically coded inequality? And what policies and conversations are urgently needed to ensure we don’t cross the line from science into dystopia?