What makes a good life? For decades, psychologists have debated whether true fulfillment comes from happiness—a life of comfort and joy—or meaning—a life of purpose and impact. But what if there's a third way?

University of Chicago psychology professor Shigehiro Oishi has spent his career studying happiness, meaning, and what truly brings people deep satisfaction. His new research suggests that some of the most fulfilled people don’t prioritize either—they live psychologically rich lives, full of novelty, challenges, and transformative experiences.

In this episode, Oishi explains why psychological richness might be the missing piece in our search for fulfillment.

Imagine a future in which Band-Aids talk to your cells, pacemakers are powered by light and your gut microbiome gets a tune-up—all thanks to tiny bioelectric devices. Sounds like sci-fi, right? Think again.

Prof. Bozhi Tian of the University of Chicago is on the frontier of bioelectronics, building living machines that can heal, enhance and maybe even transform what it means to be human. In this episode, he explains his research lab’s work and explores the thrilling, strange and sometimes unsettling world in which biology meets technology.

Five years after COVID became a global pandemic, could another health crisis be on our horizon? According to scientists who study diseases, the possibility of a fungal pandemic—the subject of science fiction TV shows like “The Last of Us,” could be more of a reality, thanks to climate change and our warming planet. As fungi are adapting to warmer climates, they are becoming increasingly stronger and more resistant against the drugs we have to fight them.

Arturo Casadevall is one of the scientists who is warning against fungi's powerful potential. He's a professor of microbiology and immunology at the Johns Hopkins’ Bloomberg School of Public Health and the author of the new book, What If Fungi Win? He explains why fungi are becoming a growing public health threat, and what tools we have to protect ourselves from a future fungal outbreak.

As we step into 2025, many of us are thinking about how to turn our New Year's resolutions into lasting changes. But what if the secret to success lies not in willpower but in the words we use every day? To kick off the year, we’re sharing our past episode with Jonah Berger, a professor at The Wharton School and author of Magic Words: What to Say to Get Your Way.

In this episode, Berger uncovers the science behind the language we use and how it shapes our habits, decisions, and relationships. From simple word swaps that can help you stay on track with your goals to strategies for using language to connect with others more effectively, this conversation is packed with insights to help you make 2025 a year of transformation.

We have long heard the claims that a glass of red wine is good for your heart, but it turns out that the research that fueled this wisdom was actually skewed. Some studies made it appear like moderate drinkers were healthier than people who didn't drink at all, leading the public to believe that alcohol was healthier than it is. While drinking alcohol occasionally might not have catastrophic effects on your health, the data shows that even moderate drinking will reduce your life expectancy.

In this episode, we speak with Tim Stockwell, a scientist at the Canadian Institute for Substance Use Research and a professor of psychology at the University of Victoria. Stockwell has reviewed hundreds of studies that he claims embellished alcohol's effects, and he explains how the new science of drinking is changing the public perception of alcohol. Today, trends like sober-curiosity and “Dry January” are on the rise, and some countries around the world are even implementing new policies around alcohol regulation.

For centuries, death has been seen as a final, inescapable line—a moment when the heart stops and the brain ceases to function. But revolutionary research asks: What if everything we thought we knew about death was wrong?

Sam Parnia, an associate professor of medicine at NYU Langone, is the author of Lucid Dying: The New Science Revolutionizing How We Understand Life and Death. His groundbreaking work explores how science is pushing the boundaries of life and death, uncovering the potential to resuscitate animals—and maybe one day humans—after they've been declared dead. From recalling experiences of consciousness after death (what some call “near-death experiences”) to using AI and advanced techniques to study the brain in its final moments, he explores the profound implications for medicine, ethics and our understanding of what it means to be alive.

This year’s election might have been the most contentious in modern memory. It's not just that politics have changed, but it seems that people have too. You’ve probably heard this phrase: “People aren’t as kind as they used to be”. Maybe you’ve experienced the feeling that people are acting meaner to each other, year after year. But is it true? Are people really less kind than they used to be?

With that question in mind, and as we take some time off for the Thanksgiving holiday, we wanted to reshare our episode with psychologist Adam Mastroianni. Mastroianni wondered if people are really becoming less moral in today's world, so he set out to find an answer, and published his findings in the journal Nature, “The Illusion of Moral Decline.” While the title may be a giveaway for his findings, he asks: If people are becoming less moral, why do we all feel the same way—and what can we do to shake this “illusion?”

What if we could predict the economy the way we predict the weather? What if governments could run simulations to forecast the effects of new policies—before they happen? And what if the key to all of this lies in the same chaotic systems that explain spinning roulette wheels and rolling dice?

J. Doyne Farmer is a University of Oxford professor, complexity scientist, and former physicist who once beat Las Vegas casinos using his scientific-based methods. In his recent book “Making Sense of Chaos: A Better Economics for a Better World” Farmer is using those same principles to build a new branch of economics called complexity economics—one that uses big data to help forecast market crashes, design better policies and find ways to confront climate change.

But can we really predict the unpredictable? And how will using chaos theory shake up well-established economic approaches?

https://haarc.center.uchicago.edu/We used to think aging inevitably led to memory loss, but a small group of people—known as SuperAgers—are defying the odds. These individuals, all over 80, have the memory performance of someone in the 50s. The question is: how?

One of the leading experts studying SuperAgers is University of Chicago neurologist Emily Rogalski. She explores the fascinating science behind SuperAgers—uncovering what makes their physical brains different and how their lifestyle choices could be the key to a having a sharper, healthier brain well into old age.

On Big Brains, we get to speak to a lot of groundbreaking scholars and experts, but some conversations we walk away knowing we’ve just heard from someone who is really changing the world. We certainly felt that way years ago after talking to University of Chicago scholar James Robinson, and it turns out…the Nobel Prize committee agreed in 2024 when it awarded him a share of the Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel.

Robinson was honored for the exact work that we talked to him about nearly five years ago. The author of numerous best-selling books, including Why Nations Fail (2012) and The Narrow Corridor (2019), he won the Nobel this year because his work researching what makes nations succeed and…what makes them fail. There’s no better time to refamiliarize ourselves with his important research and celebrate his Nobel win.