The Next Big Idea

Humans have been imbibing for thousands of years. What has drinking contributed to society? What is it doing to our health?

Guests: Edward Slingerland (”Drunk: How We Sipped, Danced, and Stumbled Our Way to Civilization”) and Susan Dominus (”Is That Drink Worth It to You?”)

🎙️ Check out Edward’s previous appearance on the show here

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Over 2,000 years ago, Epicurus, a Greek philosopher, made a simple yet bold claim. The key to the good life, he said, is to pursue pleasure and avoid pain. Is it really that easy? To answer that question, we turn to Emily Austin, a professor of philosophy at Wake Forest and author of “Living for Pleasure: An Epicurean Guide to Life.”

(This episode first aired in January 2023.)

Back in the 1700s, in a spa town outside of London, Thomas Bayes, a Presbyterian minister and amateur mathematician, invented a formula that lets you figure out how likely something is to happen based on what you already know. It changed the world. Today, pollsters use it to forecast election results and bookies to predict Super Bowl scores. For neuroscientists, it explains how our brains work; for computer scientists, it's the principle behind artificial intelligence.

In this episode, we explore the modern-day applications of this game-changing theorem with the help of Tom Chivers, author of the new book "Everything Is Predictable: How Bayesian Statistics Explain Our World."

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So you want to eat healthy. But how do you actually go about doing that? Today, Casey Means — Stanford-trained physician, founder of Levels, and author of the #1 New York Times bestseller “Good Energy” — shares the science-backed dietary guide you need.

💿 Ready for more interviews that will supercharge your health? Check out our Spotify playlist

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Bad news: 93% of Americans are metabolically unhealthy. Their bodies struggle to convert food into the energy their cells need. And this fuel shortage underlies all sorts of conditions, from diabetes and cancer to insomnia and erectile dysfunction.

Good news: Simple changes to how we eat and exercise can dramatically improve our metabolic health.

This is the thesis of “Good Energy: The Surprising Connection Between Metabolism and Limitless Health” by Casey Means. A Stanford-trained physician, Casey grew disillusioned with conventional healthcare when she realized that many doctors are great at prescribing pills and performing surgeries but hopeless when it comes to addressing root causes. This led her to leave traditional medicine and focus on combating metabolic dysfunction, which she believes is at the heart of America’s health crisis.

Today on the show, she tells Rufus about her journey, explains why she thinks the medical system fails patients, and shares the simple biomarkers that you should check to see if you’re at risk for a deadly disease.

📱 This is part one of our interview with Casey. Part two will be available here on Thursday. But if you can't wait that long, you can listen right now on the Next Big Idea app: https://nextbigideaclub.com/app/

Publisher, scientist, humorist, diplomat — Benjamin Franklin was America's first polymath. Today, with help from Eric Weiner, we revisit Franklin's life, searching for tips about how to be healthy, wealthy, and wise.

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Where is AI headed, and how quickly will it get there? Should we be early adopters or keep our distance? Will it make our lives better or put us out of work?

We can’t think of a better person to answer these questions than Bill Gates. He’s played a leading role in every major tech development over the last half-century, and he’s got a pretty good track record when it comes to forecasting the future. Back in 1980, he predicted that one day there’d be a computer on every desk; today on the show, he says there will soon be an AI agent in every ear.

Rufus and Bill are joined by Andy Sack and Adam Brotman, co-authors of an exciting new book called “AI First.” Together, they consider AI’s impact on healthcare, education, productivity, and business. They dig into the technology’s risks. And they explore its potential to cure diseases, enhance creativity, and usher in a world of abundance.

📕 To learn more about Andy and Adam’s AI lab, Forum3, visit https://www.forum3.com. And for exclusive insights from their book, “AI First,” head to https://www.forum3.com/book

🎁 If you love the show, the best way to let us know is by becoming a Next Big Idea Club member. Learn more at https://nextbigideaclub.com/ and use code PODCAST to get 20% off your subscription

Today, Adam Grant and Bob Sutton, two legends of organizational psychology, discuss Bob’s new book, “The Friction Project: How Smart Leaders Make the Right Things Easier and the Wrong Things Harder.”

🎙️ This interview first appeared on Adam’s podcast, “ReThinking.” Follow it now on Apple Podcast or Spotify.

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Steven Johnson returns! He's with us today to talk about his new book, "The Infernal Machine: A True Story of Dynamite, Terror, and the Rise of the Modern Detective," and his new day job helping Google develop AI tools for writers.

🔊 You can listen to Steven's previous appearances on this show here, here, here and here

🎧 To purchase a copy of Steven's Next Big Idea Original audiobook, "Immortality: A User's Guide," head here: https://nextbigideaclub.supportingcast.fm/immortality-a-users-guide

📩 Be sure to check out his Substack, too: https://adjacentpossible.substack.com/

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Could embracing uncertainty be the key to thriving in our age of unpredictability? That's the premise of Maggie Jackson's new book, "Uncertain: The Wisdom and Wonder of Being Unsure," which was chosen by our curators — Malcolm Gladwell, Adam Grant, Susan Cain, and Daniel Pink — as one of the year's best works of nonfiction. Maggie sat down with our co-founder Panio Gianopoulos to discuss how mastering the art of being unsure can fuel leadership, deepen relationships, and inspire creativity.

Host: Panio Gianopoulos

Guest: Maggie Jackson

*The Next Big Idea Club*

We all know that reading is the best investment we can make in ourselves. But figuring out what to read — well, that's another matter. Which is why we started the Next Big Idea Club. We get the best new books (as chosen by our friends Malcolm Gladwell, Adam Grant, Susan Cain, and Daniel Pink) into the hands of curious people. Like you! Join us today at nextbigideaclub.com