Christina Applegate and Jamie-Lynn Sigler have been stars for decades–who can forget their turns in Anchorman and The Sopranos respectively?--but they share a sisterhood with each other: they’ve both been diagnosed with MS. Their podcast MeSsy is all about supporting each other and listeners through whatever curveballs life throws their way, and Katie was delighted to sit down on the interviewee side of the desk to discuss her activism around raising awareness for cancer–and also have some fun. From moving moments at Stand Up to Cancer benefits to stripper names and that one word everyone misuses this interview will have you in stitches.

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